This paper is only available as a PDF. To read, Please Download here.
The bone mineral density (BMD) of the lumbar vertebrae (L2–L4) and of the whole body
were measured in cross-sectional and longitudinal studies in female patients with
eating disorders, using dual photon absorptiometry before and after weight gain with
or without resumption of menses.
In the cross-sectional study, the low-body-weight anorectic patients, with or without
bulimia nervosa, were found to have lower BMD of the lumbar vertebrae associated with
severe weight loss, low physical activity, and earlier onset and longer duration of
amenorrhea.
In the longitudinal study, 11 patients attained subnormal body weight (70%SBW ≦ ∼
< 85% SBW), 10 patients attained normal body weight (≧ 85%SBW, 6 patients of them
resumed regular menses) after treatment. The BMD of the lumbar vertebrae was found
to increase with weight gain, but not to the control level. The BMD was further increased
with the resumption of menses in patients with anorexia nervosa. These results suggest
that resumption of menses, in addition to weight gain, is essential to normalize reduced
bone mineral density.
Key Words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological PsychiatryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Osteopenia in hypoestrogenic young women with anorexia nervosa.Fertil Steril. 1984; 41: 224-228
- Decreased bone density in adolescent girls with anorexia nervosa.Pediatrics. 1990; 86: 440-447
- Recovery from osteopenia in adolescent girls with anorexia nervosa.J Clin Endocrinol Metab. 1991; 72: 602-606
- Mechanism of osteoporosis in adult and adolescent women with anorexia nervosa.J Clin Endocrinol Metab. 1989; 68: 548-554
- Osteoporosis and pathologic fracture in anorexia nervosa.Am J Psychiatry. 1985; 142: 495-496
- The effect of anorexia nervosa on bone morphometry in young women.Clin Orthop. 1985; 201: 271-272
- Reduced bone mineral in patients with eating disorders.Bone. 1990; 11: 143-147
- Investigation of osteopenia in anorexia nervosa.Aust N Z T Psychiatry. 1989; 23: 261-268
- The effect of bulimia upon diet, body fat, bone density, and blood component.J Am Diet Assoc. 1989; 89: 929-934
- Comparison of bone density in amenorrheic women due to athletics, weight loss, and premature menopause.Obstet Gynecol. 1985; 66: 5-8
- Osteoporosis in women with eating disorders: comparison of physical parameters, exercise, and menstrual status with SPA and DPA evaluation.J Nucl Med. 1990; 31: 325-331
- Osteoporosis and hip fracture in young women with anorexia nervosa.Clin Orthop. 1986; 212: 250-254
- Reduced bone density and major hormones regulating calcium metabolism in anorexia nervosa.Acta Psychiatr Scand. 1992; 86: 358-363
- Postpartum signal wedge fracture in a 27-year-old epileptic anorectic woman.Aust N Z J Obstet Gynaecol. 1987; 27: 71-74
- (0000)Bone mineral content in normal U.S. whites.in: Mazess RB International Conference on Bone Mineral Measurement. HEW, Washington DC1974
- Skeletal and bodycomposition effects of anorexia nervosa.Am J Clin Nutr. 1990; 52: 438-441
- Rib fractures and anorexia nervosa.J Adolesc Health Care. 1983; 4: 40-43
- Relationship of bone density to estradiol and cortisol in anorexia nervosa and bulimia.Psychiatry Res. 1989; 29: 105-112
- A longitudinal study of metacarpal bone morphometry in anorexia nervosa.Clin Orthop. 1992; 278: 217-225
- Osteoporosis in women with anorexia nervosa.N Engl J Med. 1984; 311: 1601-1606
- Osteopenia and bone fractures in a man with anorexia nervosa and hypogonadism.JAMA. 1986; 256: 385-388
- The clinical course of osteoporosis in anorexia nervosa.JAMA. 1991; 265: 1133-1138
- Knochenabbau bei Patientinnen mit Anorexia nervosa.Schweiz Med Wschr. 1988; 118: 233-238
- The effect of anorexia nervosa on skin thickness, skin collagen and bone density.Br J Obstet Gynaecol. 1989; 96: 1392-1394
- Premature loss of bone in chronic anorexia nervosa.Br Med J. 1985; 290: 26-27
- Reversible bone loss in anorexia nervosa.Br Med J. 1987; 295: 474-475
Article info
Publication history
Received in revised form:
June 24,
1994
Received:
July 20,
1993
Identification
Copyright
© 1995 Society of Biological Psychiatry. Published by Elsevier Inc.
