Original article| Volume 37, ISSUE 6, P410-413, March 15, 1995

Specific IgA antibody increases in schizophrenia

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      IgA antibody levels in serum were examined in two groups of schizophrenic patients. All were diagnosed according to DSM-III-R criteria. One group of 36 males and 12 females were compared to historical controls. The other group consisted of 13 males off drugs for at least 3 months; these were compared with age -and sex-matched controls. An increase in specific IgA antibodies was found. More schizophrenics than controls showed IgA antibody levels above the upper normal limit to gliadin, beta-lactoglobulin, and casein.

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        • Abassi Z
        • Golomb E
        • Keiser HR
        Neutral endopeptidase inhibition increases the urinary excretion and plasma levels of Endothelin.
        Metab. 1992; 41: 683-685
        • Alpers DH
        Uptake and fate of absorbed amino acid and peptides in the mammalian intestine.
        Fed Proc. 1986; 452: 261-267
        • Ashkenazi A
        • Krasilowsky D
        • Levin S
        • Idar D
        • Kalian M
        • Hyala O
        • Ginat Y
        • Halperin B
        Immunological reaction of psychotic patients to fractions of gluten.
        Amer J Psychiat. 1979; 136: 1306-1309
        • Axelsson I
        • Jacobsson I
        • Lindberg T
        • Benediktsson B
        Bovine beta-lactoglobulin in human milk.
        Acta Paed Scand. 1986; 75: 702-707
        • Baitner K
        Intestinal absorption of macromolecules in the adult.
        in: Intestinal Absorption of Macromolecules and Immune Transmission from Mother to Young. CRC Press, New York1986: 135-153
        • Bøhlen P
        • Castillo F
        • Ling R
        • Guillemin R
        An efficient procedure for the separation of peptides from amino acids and salts.
        Int J Peptide Prot Res. 1980; 16: 306-310
        • Cade R
        • Wagemaker H
        • Privette RM
        • Fregly MJ
        • Rogers J
        • Orlando J
        Effect of dialysis and diet in schizophrenia.
        Psychiatry: A World Perspective. 1990; 3: 494-500
        • Dohan FC
        • Martin L
        • Grasberger JC
        • Boehme D
        • Cotrell JC
        Antibodies to wheat gliadin in blood of psychiatric patients: Possible role of emotional factors.
        Biol Psychiatry. 1972; 5: 127-137
        • Dohan FC
        • Grasberger JC
        Relapsed schizophrenics: Earlier discharge from hospital after cereal-free, milk-free diet.
        Amer J Psychiatry. 1973; 130: 685-688
        • Dohan FC
        Hypothesis: Genes and neuroactive peptides from food as a cause of schizophrenia.
        in: Costa E Trabucci M Neural Peptides and Neuronal Communication. Raven Press, Boca Raton, FL1980: 535-548
        • Dohan FC
        • Harper EH
        • Clark MH
        • Rodrigue RB
        • Zigas V
        Is schizophrenia rare if grain is rare?.
        Biol Psychiatry. 1984; 19: 385-399
        • Drysdale A
        • Deacon R
        • Lewis P
        • Olly S
        • Electricwala A
        • Sherwood R
        A peptide containing fraction of plasma of schizophrenic patients which binds to opiate receptors and induces hyperactivity in rats.
        Neuroscience. 1982; 7: 1567-1574
        • Fukudome SI
        • Yoshikawa M
        Opioid peptides derived from wheat gluten: Their isolation and characterization.
        Febs Lett. 1992; 296: 107-111
        • Fukudome SI
        • Yoshikawa M
        Gluten exorphin C, a novel opioid peptide derived from wheat gluten.
        Febs Lett. 1993; 316: 17-19
        • Gardner MLG
        Evidence for, and implications of passage of intact peptides across the intestinal mucosa.
        Biochem Soc Trans. 1983; 11: 810-812
        • Hekkens WTJM
        • Schipperijn AJM
        • Freed DLJ
        Antibodies to wheat proteins in schizophrenia: relationship or coincidence?.
        in: Hemmings G Biochemistry of Schizophrenia and Addiction. MPT Press, New York1980: 125-133
        • Hekkens WTJM
        The evolution in research in prolamin toxicity: From bread to peptide.
        in: Somogyi JC Muller HR Ockhuizen TH Food Allergy and Food Intolerance: Nutritional Aspects and Development. Bibl Nutr Dietica, Lancaster, UK1991: 90-104
        • Husby S
        • Jensenius JC
        • Svehag SE
        Passage of undegraded dietary antigen into the blood of healthy adults.
        Scand J Immunol. 1985; 22: 83-92
        • Idet M
        • Grof J
        • Menyhart J
        • Pajor A
        Elevated opioid activity in sera of chronic schizophrenics.
        Acta Physiol Acad Hung. 1982; 60: 121-127
        • Kinnell HG
        • Kirkwood E
        • Lewis C
        Food antibodies in schizophrenia.
        Psychol Med. 1982; 12: 85-89
        • Lindstr LH
        • Nyberg F
        • Terenius L
        • et al.
        CSF and plasma beta-casomorphin like opioid peptides in post-partum psychosis.
        Am J Psychiatry. 1984; 41: 1059-1066
        • Lorenz K
        Cereals and schizophrenia.
        Adv cereal Sci Technol. 1990; X: 435-469
        • Lunde H
        • Sjaastad ̊
        • Gjessing LR
        Homocamosinosis; hyperhomocarnosinuria.
        J Neurochem. 1982; 38: 242-245
        • Mahe S
        • Tume D
        • Demontier AM
        • Desjeux JF
        Absorption of intact morhiceptin by diisopropylfluorophospahe-treated rabbit ileum.
        Peptides. 1989; 10: 45-52
        • Mascord I
        • Frede D
        • Durrant B
        Antibodies to foodstuffs in schizophrenia.
        Br Med J. 1978; i: 1351
        • Myara I
        • Charpentier C
        • Lemonnier A
        Prolidase and prolidase deficiency.
        Life Sci. 1984; 34: 1985-1988
        • Reichelt KL
        • Hole K
        • Hamberger A
        • et al.
        Biologically active peptide-containing fractions in schizophrenia and childhood autism.
        Adv Biochem Psychopharmacol. 1981; 28: 627-643
        • Reichelt KL
        • Edminson PD
        • Toft KG
        Urinary peptides in schizophrenia and depression.
        Stress Med. 1985; 1: 169-181
        • Reichelt KL
        • Edminson PD
        Principles in isolation of peptide factors from urines with retained biological activity: example from schizophrenia.
        in: Kalasz H Ettre LS Chromatography: The State of the Art. Hungarian, Karger1985: 237-256
        • Reichelt KL
        • Sagedal E
        • Landmark J
        • Sangvik BT
        • Eggen O
        • Scott H
        The effect of gluten-free diet on urinary peptide excretion and clinical state in schizophrenia.
        J Ontomol Med. 1990; 5: 223-239
        • Reichelt KL
        • Capellen C
        • ̊ye I
        Schizophrenia responding to hemodialysis: A rare subtype? presence of opioid immunoreactive to bovine casomorphin antibodies.
        Nordisk Psyk Tidskrift. 1994; (in press)
        • Rix KJB
        • Ditchfield J
        • Freed DLJ
        • Goldberg DP
        • Hillier VF
        Food antibodies in acute psychoses.
        Psychol Med. 1985; 15: 347-354
        • Scott H
        • Rognum TO
        • Brandtzaeg P
        Performance testing of antigen coated polystyrene microplates for ELISA measurements of serum antibodies to bacteria and dietary antigens.
        Acta Patrol Microbiol Immunol Scand. 1985; 93: 117-123
        • Scott H
        • Rognum TO
        • Midtvedt TJ
        • Barndtzaeg P
        Age-related changes in human serum antibodies to dietary and colonic bacterial antigens measured by enzyme-linked immunosorbent assay.
        Acta Pathol Microbiol Immunol Scand. 1985; 93: 65-70
        • Singh MM
        • Kay SR
        Wheat gluten as a pathogenic factor in schizophrenia.
        Science. 1976; 191: 401-402
        • Stuart CA
        • Twiselton R
        • Nicholas M
        • Hide DW
        Passage of cow's milk protein in breast milk.
        Clin Allergy. 1984; 14: 533-535
        • Sugerman AA
        • Southern DL
        • Curran JF
        A study of antibody levels in alcoholic, depressive and schizophrenic patients.
        Ann Allergy. 1982; 48: 166-171
        • Troncone R
        • Scarcella A
        • Donatiello A
        • Cannataro P
        • Tarabusco A
        • Auricchio S
        Passage of gliadin into human breast milk.
        Acta Paediatr Scand. 1987; 76: 453-456
        • Webb KE
        Amino acid and peptide absorption from the gastrointestinal tract.
        Fed Proc. 1986; 45: 2268-2271