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Recently, renewed interest has developed in the concept of anxious depression. Using
an operational definition of “anxious depression” based on the SADS interview, 25
patients with major depressive disorder were separated into anxious (n = 14) and nonanxious
(n = 11) subtypes. These two patient groups and normal control subjects received an
intravenous corticotropin-releasing hormone challenge test. Adrenocorticotropic hormone
(ACTH) and cortisol responses were compared among the three groups. Patients with
anxious depression had significant attenuation of ACTH response when compared to nonanxious
patients and normal control subjects.
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Article info
Publication history
Received in revised form:
January 3,
1994
Received:
April 22,
1993
Footnotes
This project was supported in part by grant RR59 of the General Clinical Research Center's Program of the Division of Research Resources, National Institute of Health.
Identification
Copyright
© 1995 Society of Biological Psychiatry. Published by Elsevier Inc.
