Advertisement

Geriatric depression: Age of onset and dementia

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Age of depression onset was studied in 183 consecutively hospitalized elderly patients with major depression. Patients with both depression and dementia had onset of depression at a significantly later age than patients with depression alone. Depressives with reversible dementia had age of onset comparable to that of depressives with irreversible dementia. These findings suggest that late-onset depression is a heterogeneous syndrome and includes a considerable number of patients who develop depression as part of a dementing illness.

      Keywords

      References

        • Alexopoulos G.S.
        Clinical and biological findings in late-onset depression.
        in: Review of Psychiatry. Vol. 9. American Psychiatric Press, Washington, DC1990
        • Alexopoulos G.S.
        • Abrams R.C.
        Depression in Alzheimer's disease.
        Psychiatr Clin North Am. 1991; 14: 327-340
        • Alexopoulos G.S.
        • Young R.C.
        • Lieberman K.W.
        • Shamoian C.A.
        Platelet MAO activity in geriatric patients with depression and dementia.
        Am J Psychiatry. 1987; 144: 1480-1483
      1. Alexopoulos GS, Meyers BS, Young RC, Mattis S, Kakuma T (in press): The course of geriatric depression with reversible dementia. Am J Psychiatry.

        • Balldwin R.C.
        • Jolley D.J.
        The prognosis of depression in old age.
        Br J Psychiatry. 1986; 149: 574-583
        • Emery V.A.
        • Oxman T.E.
        Update on the dementia spectrum of depression.
        Am J Psychiatry. 1992; 149: 305-317
        • Hamilton M.
        A rating scale for depression.
        J Neurol Neurosurg Psychiatry. 1960; 23: 56-62
        • Jacobs J.
        • Bernhard M.
        • Delgado A.
        • Strain J.
        Screening for organic mental syndromes in the medically ill.
        Ann Intern Med. 1977; 86: 40-46
        • Kellner M.B.
        • Lavori P.W.
        • Friedman B.
        • et al.
        The longitudinal interval follow-up evaluation. A comprehensive method for assessing outcome in prospective longitudinal studies.
        Arch Gen Psychiatry. 1987; 44: 540-548
        • Kral V.A.
        • Emery O.B.
        Long-term follow-up of depressive pseudodementia of the aged.
        Can J Psychiatry. 1989; 34: 445-446
        • Mendlewicz J.
        • Baron M.
        Morbidity risks in subtypes of unipolar depressive illness. Differences between early- and late-onset forms.
        Br J Psychiatry. 1991; 134: 463-466
        • Murphy E.
        The prognosis of depression in old age.
        Br J Psychiatry. 1983; 142: 111-119
        • Post F.
        Dementia, depression and pseudodementia.
        in: Benson D.F. Blumer D. Psychiatric Aspects of Neurologic Disease. Seminars in Psychiatry series. Grune and Stratton, New York1979: 99-120
        • Sacchetti E.
        • Conte C.
        • Pennati A.
        • Vita A.
        • Alciati A.
        • Cazzullo C.L.
        Platelet alpha2-adrenoreceptors in major depression: Relationship with urinary 4-hydroxy-3-methoxyphenylglycol and age at onset.
        J Psychiatr Res. 1985; 9: 579-586
        • Spitzer R.L.
        • Williams J.B.W.
        Structured Clinical Interview for DSM-III-R, Patient Version.
        Biometrics Research Department, New York State Psychiatric Institute, New York1985
        • Veith R.C.
        • Raskind M.A.
        The neurobiology of aging: Does it predispose to depression?.
        Neurobio Aging. 1988; 9: 101-117