This paper is only available as a PDF. To read, Please Download here.
Abstract
Age of depression onset was studied in 183 consecutively hospitalized elderly patients with major depression. Patients with both depression and dementia had onset of depression at a significantly later age than patients with depression alone. Depressives with reversible dementia had age of onset comparable to that of depressives with irreversible dementia. These findings suggest that late-onset depression is a heterogeneous syndrome and includes a considerable number of patients who develop depression as part of a dementing illness.
Keywords
References
- Clinical and biological findings in late-onset depression.in: Review of Psychiatry. Vol. 9. American Psychiatric Press, Washington, DC1990
- Depression in Alzheimer's disease.Psychiatr Clin North Am. 1991; 14: 327-340
- Platelet MAO activity in geriatric patients with depression and dementia.Am J Psychiatry. 1987; 144: 1480-1483
Alexopoulos GS, Meyers BS, Young RC, Mattis S, Kakuma T (in press): The course of geriatric depression with reversible dementia. Am J Psychiatry.
- The prognosis of depression in old age.Br J Psychiatry. 1986; 149: 574-583
- Update on the dementia spectrum of depression.Am J Psychiatry. 1992; 149: 305-317
- A rating scale for depression.J Neurol Neurosurg Psychiatry. 1960; 23: 56-62
- Screening for organic mental syndromes in the medically ill.Ann Intern Med. 1977; 86: 40-46
- The longitudinal interval follow-up evaluation. A comprehensive method for assessing outcome in prospective longitudinal studies.Arch Gen Psychiatry. 1987; 44: 540-548
- Long-term follow-up of depressive pseudodementia of the aged.Can J Psychiatry. 1989; 34: 445-446
- Morbidity risks in subtypes of unipolar depressive illness. Differences between early- and late-onset forms.Br J Psychiatry. 1991; 134: 463-466
- The prognosis of depression in old age.Br J Psychiatry. 1983; 142: 111-119
- Dementia, depression and pseudodementia.in: Benson D.F. Blumer D. Psychiatric Aspects of Neurologic Disease. Seminars in Psychiatry series. Grune and Stratton, New York1979: 99-120
- Platelet alpha2-adrenoreceptors in major depression: Relationship with urinary 4-hydroxy-3-methoxyphenylglycol and age at onset.J Psychiatr Res. 1985; 9: 579-586
- Structured Clinical Interview for DSM-III-R, Patient Version.Biometrics Research Department, New York State Psychiatric Institute, New York1985
- The neurobiology of aging: Does it predispose to depression?.Neurobio Aging. 1988; 9: 101-117
Article info
Publication history
Received in revised form:
April 21,
1993
Received:
September 19,
1992
Footnotes
☆This study was supported by NIMH grants R01 MH-42819, T32 MH-19132, T01 MH-19596, and by the Xerox Foundation.
Identification
Copyright
© 1993 Published by Elsevier Inc.
User license
Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0) | How you can reuse 
Elsevier's open access license policy
Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)
Permitted
For non-commercial purposes:
- Read, print & download
- Redistribute or republish the final article
- Text & data mine
- Translate the article (private use only, not for distribution)
- Reuse portions or extracts from the article in other works
Not Permitted
- Sell or re-use for commercial purposes
- Distribute translations or adaptations of the article
Elsevier's open access license policy
