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Original article| Volume 33, ISSUE 5, P380-387, March 01, 1993

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Transient impairment in P50 auditory sensory gating induced by a cold-pressor test

  • Michael R. Johnson
    Footnotes
    Affiliations
    Institute of Psychiatry, Medical University of South Carolina, Charleston, South Carolina, USA
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  • Lawrence E. Adler
    Correspondence
    Address reprint requests to L.E. Adler, M.D., Box C268-16, Psychiatry, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA.
    Footnotes
    Affiliations
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado USA
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  • Author Footnotes
    ∗ The authors wish to thank Mr. Lee Hoffer for preparing Figure 3.
DOI:https://doi.org/10.1016/0006-3223(93)90328-B
Transient impairment in P50 auditory sensory gating induced by a cold-pressor test
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      Abstract

      Dininished gating of the auditory evoked responses to repeated stimuli is a psychophysiological defect associated with schizophrenia and several other psychiatric illnessesThe P50 wave of the auditory evoked response to the second of paired stimuli is decreased in most normal subjects, whereas many psychotic subjects show significantly less decrement. The aim of this experiment was to test whether the cold-pressor test, which causes transient distress and pain accompanied by increased sympathetic activity, also causes a transient impairment in P50 auditory sensory gating in normal control subjects. Ten normal control subjects with normal gating of the P50 response immersed their hands in an ice water bath for 2 min. This cold-pressor test diminished P50 auditory gating in nine of these subjects, although the degree of impairment was highly variable among subjects. The impairment in gating was transient, with partial resolution by 30 min. The cold-pressor test was subjectively viewed as painful and also caused blood pressure to increase. Thus, a transient stressor can impair P50 auditory gating in some subjects.

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      References

        • Adams L.M.
        • Geyer M.A.
        Effects of 6-hydroxydopamine lesions of locus coeruleus on starle in rats.
        Psychopharmacology (Berlin). 1981; 73: 394-398
        • Adler L.E.
        • Rose G.M.
        • Freedman R.
        Neurophysiologic studies of sensory gating in rats: effects of amphetamine, phencyclidine and haloperidol.
        Biol Psychiatry. 1986; 21: 787-798
        • Adler L.E.
        • Pang K.
        • Gerhardt G.
        • Rose G.M.
        Modulation of the gating of auditory evoked potentials by norepinephrine: pharmacological evidence obtained using a selective neurotoxin.
        Biol Psychiatry. 1988; 24: 179-190
        • Adler L.E.
        • Pachtman E.
        • Franks R.D.
        • Pecevich M.
        • Waldo M.C.
        • Freedman R.
        Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia.
        Biol Psychiatry. 1982; 17: 639-654
        • Adler L.E.
        • Gerhardt G.A.
        • Franks R.
        • et al.
        Sensory physiology and catecholamines in schizophrenia and mania.
        Psychiatry Res. 1990; 31: 297-309
        • Adler L.E.
        • Hoffer L.
        • Nagamoto H.T.
        • Waldo M.C.
        • Perkins R.
        • Freedman R.
        Yohimbine causes a transient impairment in P50 auditory sensory gating (Abstract 575.10).
        in: Society of Neuroscience, 21st Annual Meeting, New Orleans1991
        • Adler L.E.
        • Hoffer L.J.
        • Griffith J.
        • Waldo M.C.
        • Freedman R.
        Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics.
        Biol Psychiatry. 1992; 32: 607-616
        • Baker N.
        • Adler L.E.
        • Franks R.D.
        • et al.
        Neurophysiologicalassessment of sensory gating in psychiatric inpatients: comparison between schizophrenia and other diagnoses.
        Biol Psychiatry. 1987; 22: 603-617
        • Baker N.J.
        • Staunton M.
        • Adler L.E.
        • et al.
        Sensory gating deficits in psychiatric inpatients: relation to catecholamine metabolites in different diagnostic groups.
        Biol Psychiatry. 1990; 27: 519-528
        • Bickford-Wimer P.C.
        • Nagamoto H.
        • Johnson R.
        • et al.
        Auditory sensory gating in hippocampal neurons: a model system in the rat.
        Biol Psychiatry. 1990; 27: 183-192
        • Boutros N.N.
        • Overall J.
        • Zouridakis G.
        Test-retest reliability of the P50 mid latency auditory evoked response.
        Psychiatry Res. 1991; 39: 181-192
        • Braff D.L.
        • Grillon C.
        • Geyer M.A.
        Gating and habituation of the startle reflex in schizophrenic patients.
        Arch Gen Psychiatry. 1992; 49: 206-215
        • Chapman C.R.
        • Colpitts Y.H.
        • Mayenko J.R.
        • Gagiloardi G.J.
        Rate of stimulus repetition changes evoked potential amplitude: dental and auditory modalities compared.
        Exp Brain Res. 1981; 43: 246-252
        • Coppola R.
        Isolating low frequency activity in EEG spectrum analysis.
        Electroencephalogr Clin Neurophysiol. 1979; 46: 224-226
        • Davis H.
        • Mast T.
        • Yoshie N.
        • Zerlin S.
        The slow response of the human cortex to auditory stimuli: recovery process.
        Electroencephalogr Clin Neurophysiol. 1966; 21: 105-113
        • Davis M.
        • Astrachan D.J.
        • Kaas E.
        Excitatory and inhibitory effects of serotonin on sensorimotor reactivity measured with acoustic startle.
        Science. 1980; 209: 521-523
        • Davis M.
        • Mansbach R.S.
        • Swerdlow N.R.
        • Campeau S.
        • Braff D.L.
        • Geyer M.A.
        Apomorphine disrupts the inhibition of acoustic starle induced by weak prepulses in rats.
        Psychopharmacology. 1990; 102: 1-4
        • Dimsdale J.E.
        • Moss J.
        Plasma catecholamines in stress and exercise.
        JAMA. 1980; 243: 340-342
        • Erwin R.J.
        • Buchwald J.S.
        Midlatency auditory evoked responses: differential recovery cycle characteristics.
        Electroencephalogr Clin Neurophysiol. 1986; 64: 417-423
        • Erwin R.J.
        • Mawhinney-Hee M.
        • Gur R.C.
        • Gur R.E.
        Mid-latency auditory evoked responses in schizophrenia.
        Biol Psychiatry. 1991; 30: 430-442
        • Finkenzeller P.
        • Keidel W.D.
        Correlates of auditory perception in averaged prestimulatory EEG-DC recording.
        in: Quantitative Analysis of the EEG, Methods and Applications. AEG-Telefunken, 1975 (reprinted in)
      22. Keidel W. Kallert S. Korth M. The Physiological Basis of Hearing. Georg Thieme Verlag, Stuttgart1975: 198 (1983)
        • Franks R.
        • Adler L.E.
        • Waldo M.
        • Alpert J.
        • Freedman R.
        Neurophysiological studies of sensory gating in mania: comparison with schizophrenia.
        Biol Psychiatry. 1983; 18: 989-1005
        • Freedman R.
        Interactions of antipsychotic drugs with norepinephrine and cerebellar neuronal: implications for the psychobiology of psychosis.
        Biol Psychiatry. 1977; 18: 537-551
        • Freedman R.
        Evoked response to repeated auditory stimuli (letter).
        Biol Psychiatry. 1990; 28: 1065-1066
        • Freedman R.
        • Adler L.E.
        • Waldo M.C.
        • Pachtman E.
        • Franks R.
        Neurophysiological evidence for a detect in inhibitory pathways in schizophrenia: comparison of medicated and drug free patients.
        Biol Psychiatry. 1983; 18: 537-551
        • Fruhstorfer H.
        • Soveri P.
        • Jarvilehto T.
        Short-term habituation of the auditory evoked response in man.
        Electroencephalogr Clin Neurophysiol. 1970; 28: 153-159
        • Geyer M.A.
        • Tapson G.S.
        Habituation of tactile starlle is altered by drugs acting on serotonin-2 receptors.
        Neuropsychopharmacology. 1988; 1: 135-137
        • Gibson C.J.
        • Wurtman R.J.
        Physiological control of brain norepinephrine syntheis by brain tyrosine concentration.
        Life Sci. 1978; 27: 1399-1406
        • Jerger K.
        • Biggins C.
        • Fein G.
        P50 suppression is not affected by attentional manipulations.
        Biol Psychiatry. 1992; 31: 365-377
        • Judd L.L.
        • McAdams L.A.
        • Budnick B.
        • Braff D.L.
        Sensory gating deficits in schizophrenia: new results.
        Am J Psychiatry. 1992; 149: 488-493
        • Kathmann N.
        • Engel R.R.
        Sensory gating in normals and schizophrenics: a failure to find strong P50 suppression in normals.
        Biol Psychiatry. 1990; 27: 1216-1226
        • Lehnert H.
        • Reinstein D.K.
        • Strowbridge B.W.
        • Wurtman R.
        Neurochemical and behavioral consequences of acute, uncontrollable stress: effects of dietary tyrosine.
        Brain Res. 1984; 303: 215-223
        • Mansbach R.S.
        • Geyer M.A.
        • Braff D.L.
        Dopaminergic stimulation disrupts sensorimotor gating in the rat.
        Psychopharmacology. 1988; 94: 507-514
        • Miller C.L.
        • Bickford P.C.
        • Luntz-Leybman V.
        • Adler L.E.
        • Gerhardt G.A.
        • Freedman R.
        Phencyclidine and auditory sensory gating in the hippocampus of the rat.
        Neuropharmacology. 1992; 31: 1041-1048
        • Nagamoto H.T.
        • Adler L.E.
        • Waldo M.C.
        • Freedman R.
        Sensory gating in schizophrenics and normal controls: effects of changing stimulation interval.
        Biol Psychiatry. 1989; 25: 549-561
        • Nagamoto H.T.
        • Adler L.E.
        • Waldo M.C.
        • Griffith J.
        • Freedman R.
        Gating of auditory response in schizophrenics and normal controls: effects of recording site and stimulation interval on the P50 wave.
        Schizophr Res. 1991; 4: 31-40
        • Papanicolau A.C.
        • Loring D.W.
        • Eisenberg H.M.
        Age-related differences in recovery cycle of auditory evoked potentials.
        Neurobiol Aging. 1984; 5: 291-295
        • Papanicolau A.C.
        • Loring D.W.
        • Eisenberg H.M.
        Evoked potential attenuation in the two-tone paradigm.
        Int J Psychobiol. 1985; 3: 23-28
        • Peng R.Y.
        • Mansbach R.S.
        • Braff D.L.
        • Geyer M.A.
        A D2 dopamine receptor agonist disrupts sensorimotor gating in rats: implications for dopaminergic abnormalities in schizophrenia.
        Neuropsychopharmacology. 1990; 3: 211-218
        • Robinson K.
        • Rudge P.
        Centrally generated auditory potentials.
        in: Haliday A.M. Evoked Potentials in Clinical Testing. Churchill Livingstone, London1982: 368-372
        • Roth W.T.
        • Kopell B.S.
        The auditory evoked response to repeated stimuli during a vigilance task.
        Psychophysiology. 1969; 6: 301-309
        • Saito H.
        • Morita A.
        • Miyazaki I.
        • Takagi K.
        Comparison of the effects of various stresses on biogenic amines in the central nervous system and animal symptoms.
        in: Usdin E. Kvetñanský R. Kopin I.J. Catecholamines and Stress. Pergamon Press, Oxford1976: 95-103
        • Schwarzkopf S.B.
        • Lamberti J.S.
        • Crilly J.F.
        • Martin R.
        • Hirt J.
        • Holley L.A.
        Combined startle and P50 measurement of sensory gating: support for a shaved neurophysiology (abstract).
        Biol Psychiatry. 1992; 31: 147A
        • Siegel C.
        • Waldo M.
        • Mizner G.
        • Adler L.E.
        • Freedman R.
        Deficits in sensory gating in schizophrenic patients and their relatives.
        Arch Gen Psychiatry. 1984; 41: 607-612
        • Spitzer R.L.
        • Endicott J.
        • Robins E.
        Research diagnostic criteria: rationale and reliability.
        Arch Gen Psychiatry. 1978; 35: 773-782
        • Stevens K.E.
        • Fuller L.L.
        • Rose G.M.
        Dopaminergic and noradrenergic modulation of amphetamine-induced changes in auditory gating.
        Brain Res. 1991; 555: 91-98
        • Stevens K.E.
        • Meltzer J.
        • Rose G.M.
        Disruption of sensory gating by the α-2 selective noradrenergic antagonist yohimbine.
        Biol Psychiatry. 1993; (in press)
        • Swerdlow N.R.
        • Braff D.L.
        • Geyer M.A.
        • Koob G.F.
        Central dopaminergic hyperactivity in rats mimics abnormal sensory gating of the acoustic startle response in schizophrenics.
        Biol Psychiatry. 1986; 21: 23-33
        • Swerdlow N.R.
        • Braff D.L.
        • Geyer M.A.
        GABAergic projection from nucleus accumbens to ventral pallidum mediates dopamine-induced sensorimotor gating deficits of acoustic startle in rats.
        Brain Res. 1990; 532: 146-150
        • Venables P.
        Input dysfunction in schizophrenia.
        in: Maher B.A. Progress in Experimental Personality Research. Academic Press, Orlando1964: 1-47
        • Waldo M.C.
        • Freedman R.
        Gating of auditory evoled responses in normal college students.
        Psychiatry Res. 1986; 19: 233-239
        • Ward M.M.
        • Mefford I.N.
        • Parker S.D.
        • et al.
        Epinephrine and norepinephrine responses in continuously collected human plasma to a series of stressors.
        Psychosom Med. 1983; 45: 471-486
        • Wilkinson L.
        SYSTAT: System for Statistics.
        in: Systat, Inc, Evanston, IL1990: 204-213

      Article info

      Publication history

      Received in revised form: December 23, 1992
      Received: May 21, 1992

      Footnotes

      ☆This work was supported by USPHS Grants MH44212, MH38321, MH00728, and the Veterans Administration Medical Research Service.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(93)90328-B

      Copyright

      © 1993 Published by Elsevier Inc.

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