Advertisement
Original article| Volume 33, ISSUE 5, P313-325, March 01, 1993

Download started.

Ok

Postural sway in children from pedigrees exhibiting a high density of alcoholism

  • Shirley Y. Hill
    Correspondence
    Address reprint requests to S.Y. Hill, Ph.D., University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213 USA.
    Affiliations
    University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Search for articles by this author
  • Stuart R. Steinhauer
    Affiliations
    University of Pittsburgh School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA

    Biometrics Research, Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania, USA
    Search for articles by this author
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      A total of 98 children participated in a study of the neurobehavioral characteristics of individuals from pedigrees in which there was a high density of alcoholism. Two groups of children were evaluated (High and Low Risk) using a sensitive movement platform and a variety of methods to challenge the motor system. High-Risk children showed a greater decrement in postural steadiness when visual input was removed than did Low-Risk children. Additionally, the monopedal stances revealed hemispheric differences in postural sway as a function of risk status. The amount of sway exhibited was correlated with the latency of P300 recorded using a visual task. Both appear to be indicators of neuropathological changes. The present results suggest that postural sway may be a neurobehavioral marker for alcoholism risk.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Aston C.E.
        • Hill S.Y.
        A segregation analysis of the P300 component of the event-related brain potential.
        Am J Hum Genet. 1988; 47 (Suppl): A127
        • Aston C.E.
        • Hill S.Y.
        Segregation analysis of alcoholism in families ascertained through a pair of male alcoholics.
        Am J Hum Genet. 1990; 46: 879-887
        • Begleiter H.
        • Porjesz B.
        • Bihari B.
        • Kissin B.
        Event-related brain potentials in boys at risk for alcoholism.
        Science. 1984; 225: 1493-1496
        • Behar D.
        • Berg C.J.
        • Rapoport J.L.
        • et al.
        Behavioral and physiological effects of ethanol in high-risk and control children: a pilot study.
        Alcoholism: Clin Exp Res. 1983; 7: 404-410
        • Clementz B.A.
        • Grove W.M.
        • Iacono W.G.
        • Sweeney J.A.
        Smooth-pursuit eye movement dysfunction and liability for schizophrenia: implications for genetic modeling.
        J Abnorm Psychol. 1992; 101: 117-129
        • Cloninger C.R.
        • Christiansen K.O.
        • Reich T.
        • Gottesman I.I.
        Implication of sex differences in the prevalences of antisocial personality, alcoholism, and criminality for familial transmission.
        Arch Gen Psychiatry. 1978; 35: 941-951
        • Cotton N.S.
        The familial incidence of alcoholism.
        J Stud Alcohol. 1979; 40: 89-116
        • Courchesne E.
        • Yeung-Courchesne R.
        Event-related brain potentials.
        in: Rutter M. Tuma A. Lann I. Assessment and Diagnosis in Child Psychopathology. Guilford Press, New York1988: 264-299
        • Drake A.I.
        • Hannay H.J.
        • Gam J.
        Effects of chronic alcoholism on hemispheric functioning: an examination of gender differences for cognitive and dichotic listening tasks.
        J Clin Exp Neuropsychol. 1990; 5: 781-797
        • Ellis R.J.
        Dichotic asymmetries in aging and alcoholic subjects.
        Alcoholism: Clin Exp Res. 1990; 6: 863-871
        • Ellis R.J.
        • Oscar-Berman M.
        Alcoholism, aging and functional cerebral asymmetries.
        Psychol Bull. 1989; 106: 128-147
        • Finley W.W.
        • Faux S.F.
        • Hutcheson J.
        • Amstutz L.
        Longlatency event-related potentials in the evaluation of cognitive function in children.
        Neurology. 1985; 35: 323-327
        • Goldstein G.
        • Shelly C.
        Neuropsychological investigation of brain lesion localization in alcoholism.
        Adv Exp Med Biol. 1980; 126: 731-743
        • Gurling H.M.D.
        • Murray R.M.
        • Ron M.A.
        Increased brain radiodensity in alcoholism: a co-twin study.
        Arch Gen Psychiatry. 1986; 43: 764-767
        • Hayes K.C.
        • Riach C.L.
        Preparatory postural adjustments and postural sway in young children.
        in: Woollacott M.H. Shumway-Cook A. Development of Posture and Gait Across the Life Span. University of South Carolina, Columbia, SC1989: 97-127
        • Hegedus A.M.
        • Tarter R.E.
        • Hill S.Y.
        • Jacob T.
        • Winsten N.E.
        Static ataxia: a possible marker for alcoholism.
        Alcoholism: Clin Exp Res. 1984; 8: 580-582
        • Hill S.Y.
        Absence of paternal sociopathy in the etiology of severe alcoholism: is there a type III alcoholism?.
        J Stud Alcohol. 1992; 53: 161-169
        • Hill S.Y.
        • Armstrong J.
        • Steinhauer S.R.
        • Baughman T.
        • Zubin J.
        Static ataxia as a psychobiological marker for alcoholism.
        Alcoholism: Clin Exp Res. 1987; 4: 345-348
        • Hill S.Y.
        • Cloninger C.R.
        • Ayre F.R.
        Independent familial transmission of alcoholism and opiate abuse.
        Alcoholism: Clin Exp Res. 1977; 1: 335-342
        • Hill S.Y.
        • Hruska D.R.
        Childhood psychopathology in families with multigenerational alcoholism.
        J Am Acad Child Adolesc Psychiatry. 1992; 31: 1024-1031
        • Hill S.Y.
        • Steinhauer S.R.
        Assessment of prepubertal and postpubertal boys and girls at risk for developing alcoholism with P300 from a visual discrimination task.
        J Stud Alcohol. 1993; (in press)
        • Hill S.Y.
        • Steinhauer S.R.
        • Park J.
        • Zubin J.
        Event-related potential characteristics in children of alcoholics from high density families.
        Alcoholism: Clin Exp Res. 1990; 14: 6-16
        • Hill S.Y.
        • Steinhauer S.R.
        • Zubin J.
        Biological markers for alcoholism: a vulnerability model conceptualization.
        in: Rivers P.C. Alcohol and Addictive Behavior: Nebraska Symposium on Motivation. University of Nebraska Press, Lincoln, NE1986: 207-256
        • Hill S.Y.
        • Steinhauer S.R.
        • Zubin J.
        • Baughman T.
        Event-related potentials as markers for alcoholism risk in high density families.
        Alcoholism: Clin Exp Res. 1988; 12: 545-554
        • Hill S.Y.
        • Steinhauer S.R.
        • Smith T.R.
        • Locke J.
        Risk markers for alcoholism in high density families.
        J Subst Abuse. 1991; 3: 351-369
        • Holzman P.S.
        • Kringlen E.
        • Levy D.L.
        • Haberman S.J.
        Deviant eye tracking in twins discordant for psychosis.
        Arch Gen Psychiatry. 1980; 37: 627-631
        • Holzman P.S.
        • Proctor L.R.
        • Hughes D.W.
        Eye tracking patterns in schizophrenia.
        Science. 1973; 181: 179-181
        • Lester D.
        Genetic theory: an assessment of the heritability of alcoholism.
        in: Chaudron D.C. Wilkinson D.A. Theories of Alcoholism. Addiction Research Foundation, Toronto1988: 1-28
        • Lester D.
        • Carpenter J.A.
        Static ataxia in adolescents and their parentage.
        Alcoholism: Clin Exp Res. 1985; 9 (From RSA abstracts No. 171): 212
        • Lex B.W.
        • Lukas S.E.
        • Greenwald N.E.
        • Mendelson J.H.
        Alcohol-induced changes in body sway in women at risk for alcoholism: a pilot study.
        J Stud Alcohol. 1988; 49: 346-356
        • Lipscomb T.R.
        • Nathan P.E.
        Blood alcohol level discrimination.
        Arch Gen Psychiatry. 1980; 37: 571-576
        • Lipscomb T.R.
        • Carpenter J.A.
        • Nathan P.E.
        Static ataxia: a predictor of Alcoholism?.
        Br J Addict. 1979; 74: 289-294
        • Lykken D.T.
        • Tellegen A.
        • Thorkelson K.
        Genetic determination of EEG frequency spectra.
        Biol Psychol. 1974; 1: 245-259
        • Martin N.G.
        • Oakeshott J.B.
        • Gibson J.B.
        • Starmer G.A.
        • Perl J.
        • Wilks A.V.
        A twin study of psychomotor and physiological responses to an acute dose of alcohol.
        Behav Genet. 1985; 15: 305-347
        • McCaul M.E.
        • Turkkan J.S.
        • Svikis D.S.
        • Bigelow G.E.
        Familial density of alcoholism: Effects on psychophysiological responses to ethanol.
        Alcohol. 1991; 8: 219-222
        • Morrow L.A.
        • Steinhauer S.R.
        • Hodgson M.J.
        Delay in P300 latency in patients with organic solvent exposure.
        Arch Neurol. 1992; 49: 315-320
        • Moskowitz H.
        Acute tolerance to behavioral impairment by alcohol in moderate and heavy drinkers.
        in: Report to U.S. Department of Transportation. National Highway Traffic Safety Administration, 1974
        • Nagoshi C.T.
        • Wilson J.R.
        Influence of family alcoholism history on alcohol metabolism, sensitivity, and tolerance.
        Alcoholism: Clin Exp Res. 1987; 11: 392-398
        • Newlin D.B.
        • Thomson J.B.
        Alcohol challenge with sons of alcoholics: a critical review and analysis.
        Psychol Bull. 1990; 108: 383-402
        • Nijokiktjien W.
        • Ruke D.-VanO
        • Voorhoeve O.
        Stabilography as a diagnostic tool in child neurology.
        Agressologie. 1976; 17D: 41-48
        • Odenrick P.
        • Sandstedt P.
        Development of postural sway in the normal child.
        Hum Neurobiol. 1984; 3: 241-244
        • O'Malley S.S.
        • Maisto S.A.
        Effects of family drinking history and expectancies on responses to alcohol in men.
        J Stud Alcohol. 1985; 46: 289-297
        • Peele S.
        Implications and limitations of genetic models of alcoholism and other addictions.
        Gen Stud Alcohol. 1986; 47: 63-73
        • Pfefferbaum A.
        • Rosenbloom M.
        • Ford J.M.
        Late event-related potential changes in alcoholics.
        Alcohol. 1987; 4: 275-281
        • Polich J.
        • Burns T.
        P300 from identical twins.
        Neuropsychologia. 1987; 25: 299-304
        • Propping P
        Genetic control of ethanol action on the central nervous system: an EEG study in twins.
        Hum Genet. 1977; 35: 309-334
        • Ristanovic D.
        • Jovanovic V.
        • Martinovic Z.
        Pattern-reversal visual evoked potentials in normal 7- to 15-year-old twins: a correlation analysis.
        Neuropsychobiology. 1989; 21: 43-47
        • Rogers T.D.
        • Deary I.
        The P300 component of the auditory event-related potential in monozygotic and dizygotic twins.
        Acta Psychiatr Scand. 1991; 83: 412-416
        • Rust J.
        Genetic effects in the cortical auditory evoked potential: a twin study.
        Electroencephalogr Clin Neurophysiol. 1975; 39: 321-327
        • Scholz E.
        • Diener H.
        • Dichgans J.
        • Langohr H.
        • Schied W.
        • Schupmann A.
        Incidence of peripheral neuropathy and cerebellar ataxia in chronic alcoholics.
        J Neurol. 1986; 233: 212-217
        • Schuckit M.
        Ethanol-induced changes in body sway in men at high alcoholism risk.
        Arch Gen Psychiatry. 1985; 42: 375-379
        • Shambes G.
        Static postural control in children.
        Am J Phys Med. 1984; 55: 53-60
        • Shumway-Cook A.
        • Woollacott M.H.
        The growth of stability: postural control fro a development perspective.
        J. Motor Behav. 1985; 17: 131-147
        • Steinhauer S.R.
        • Hill S.Y.
        Auditory event-related potentials in children at high risk for alcoholism.
        J Stud Alcohol. 1993; (in press)
        • Steinhauer S.R.
        • Hill S.Y.
        • Zubin J.
        Event-related potentials in alcoholics and their first degree relatives.
        Alcohol. 1987; 4: 307-314
        • Steinhauer S.R.
        • Zubin J.
        • Condray R.
        • Shaw D.B.
        • Peters J.L.
        • van Kammen D.P.
        Electrophysiological and behavioral signs of attentional disturbance in schizophrenics and their siblings.
        in: Schizophrenia Research. Advances in Neuropsychaitry and Psychopharmacology. Vol. 1. Raven Press, New York1991: 169-178
        • Surwillo W.W.
        Cortical evoked potentials in monozygotic twins and unrelated subjects: comparisons of exogenous and endogenous components.
        Behav Genet. 1980; 10: 201-209
        • Victor M.
        • Adams R.D.
        • Mancall E.L.
        A restricted form of cerebellar cortical degeneration occuring in alcoholic patients.
        Arch Neurol. 1959; 1: 579-688
        • Williams H.G.
        • Fisher J.M.
        • Tritschler K.
        Descriptive analysis of static postural control in 4, 6, and 8 year old normal and motorically awkward children.
        Am J Phys Med. 1983; 62: 12-26
        • Young J.P.R.
        • Lader M.H.
        • Fenton G.W.
        A twin study of the genetic influences on the electroencephalogram.
        J Med Genet. 1972; 9: 13-16