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Research Article| Volume 33, ISSUE 4, P304-306, February 15, 1993

Elevated plasma dopamine in posttraumatic stress disorder: A preliminary report

  • Mark B. Hamner
    Correspondence
    Address reprint requests to Mark B. Hamner, M.D., 116A Psychiatry Service, VA Medical Center, 109 Bee Street, Charleston, SC 29403.
    Footnotes
    Affiliations
    Department of Psychiatry and Health Behavior, Veterans Administration, and Medical College of Georgia, Augusta, Georgia, USA
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  • Bruce I. Diamond
    Footnotes
    Affiliations
    Department of Psychiatry and Health Behavior, Veterans Administration, and Medical College of Georgia, Augusta, Georgia, USA
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  • Author Footnotes
    ∗ We thank Thuy Nguyen, for help with catecholamine testing; Rhonda Fry and Kathy Pardue, for manuscript preparation; Drs. Ana Hitri, Richard Borison, and Patrick Boudewyns, for their help and advice with this study; and Dr. Philip Rust, Medical University of South Carolina, for statistical consultation.
DOI:https://doi.org/10.1016/0006-3223(93)90302-T
Elevated plasma dopamine in posttraumatic stress disorder: A preliminary report
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      References

        • American Psychiatric Association (APA)
        3rd ed. Diagnostic and Statistical Manual of Mental Disorders. APA Press, Washington, DC1987
        • Faustman W.O.
        • White P.A.
        Diagnostic and psychopharmacological treatment characteristics of 536 inpatients with posttraumatic stress disorder.
        J Nerv Ment Dis. 1989; 17: 154-159
        • Goldberg L.I.
        Cardiovascular and renal actions of dopamine: potential clinical applications.
        Pharmacol Rev. 1972; 24: 1-29
        • Hamner M.B.
        • Diamond B.I.
        • Hitri A.
        Plasma catecholamines in PTSD.
        Biol Psychiatry. 1989; 25: 34A-35A
        • Hamner M.B.
        • Hitri A.
        Plasma beta-endorphin levels in post-traumatic stress disorder: A preliminary report on response to exercise-induced stress.
        J Neuropsychiatry Clin Neurosci. 1992; 4: 59-63
        • Kolb L.C.
        A neuropsychological hypothesis explaining PTSD.
        Am J Psychiatry. 1987; 114: 989-995
        • Krystal J.H.
        • Kosten T.R.
        • et al.
        Neurobiological aspects of PTSD: review of clinical and preclinical studies.
        Behav Ther. 1989; 20: 177-198
        • Lokhondwala M.
        • Barrett R.J.
        Cardiovascular dopamine receptors: physiological, pharmaceutical and therapeutic implications.
        J Auton Pharmacol. 1982; 3: 189-215
        • McFall M.E.
        • Murburg M.M.
        • Ko G.N.
        • Ueith R.C.
        Autonomic response to stress in Vietnam combat veterans with post-traumatic stress disorder.
        Biol Psychiatry. 1990; 27: 1165-1175
        • Mantz J.
        • Thierry A.M.
        • Glowinski J.
        Effect of noxious tail pinch on the discharge rate of mesocortical and mesolimbic dopamine neurons: selective activation of the mesocortical system.
        Brain Res. 1989; 476: 377-381
        • Minegishi A.
        • Ishizaki T.
        Determination of free 3-methoxy-4-hydrozyphenylglycol with several other monoamine metabolites in plasma by high performance liquid chromatography with amperometric detection.
        J Chromatogr. 1984; 311: 51-57
        • Mueser K.T.
        • Butler R.W.
        Auditory hallucinations in combat-related chronic post-traumatic stress disorder.
        Am J Psychiatry. 1987; 144: 299-302
        • Rajfer S.I.
        • Davis F.R.
        Role of dopamine receptors and the utility of dopamine agonists in heart failure.
        Circulation. 1990; 82 (Suppl): 92-102
        • Roy-Byrne P.
        • Uhde T.W.
        • Sack D.A.
        • et al.
        Plasma HVA and anxiety in patients with panic disorder.
        Biol Psychiatry. 1986; 21: 847-849
        • Stoddard S.L.
        • Bergdall V.K.
        • Townsend D.W.
        • Levin B.E.
        Plasma catecholamines associated with hypothalamicaly elicited defense behavior.
        Physiol Behav. 1986; 36: 867-873
        • Stoddard S.L.
        • Bergdall V.K.
        • Townsend D.W.
        • Levin B.E.
        Plasma catecholamines associated with hypothalamicaly elicited flight behavior.
        Physiol Behav. 1986; 37: 709-715
        • Thierry A.M.
        • Tassin T.P.
        • Blanc G.
        • et al.
        Selective activation of the mesocortical dopamine system by stress.
        Nature. 1976; 203: 242-244
        • van der Kolk B.
        • Greenberg M.
        • Boyd H.
        • Krystal J.
        Inescapable shock, neurotransmitters, and addiction to trauma: towards a psychobiology of post-traumatic stress.
        Biol Psychiatry. 1985; 20: 314-325
        • Yehuda R.
        • Southwick S.
        • Giller E.L.
        • Ma X.
        • Mason J.W.
        Urinary catecholamine excretion and severity of PTSD symptoms in Vietnam combat veterans.
        J Nerv Ment Dis. 1992; 180: 321-325

      Article info

      Publication history

      Received in revised form: November 17, 1992
      Received: October 29, 1990

      Footnotes

      ☆Initially presented in part at the Society of Biological Psychiatry Annual Meeting, May 1990, New York, and at the American Psychiatric Association Annual Meeting, May 1990, New York.

      ☆☆This work was supported in part by the Veterans Administration and a Medical College of Georgia biomedical research support grant.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(93)90302-T

      Copyright

      © 1993 Published by Elsevier Inc.

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