This paper is only available as a PDF. To read, Please Download here.
Abstract
The authors performed spectral analysis of electroencephalograms (EEG), recorded awake, with eyes closed, in 13 patients with schizophrenia and 9 age-matched individuals without psychiatric diagnosis. We tested several possible parameterizations of the data, and two data-reduction strategies; these yielded similar results. Comparison of the two groups revealed a relative increase in alpha frequency activity in the frontal regions in the patient group. The authors believe that this finding is consistent with data from neuropsychologic tests, metabolic imaging studies, and evoked potential studies that suggest impaired activation of frontal brain areas in patients with schizophrenia.
Keywords
References
- Sensory physiology and catecholamines in schizophrenia and mania.Psychiatry Res. 1990; 31: 297-309
- The frontal lobes, basal ganglia, and temporal lobes as sites for schizophrenia.Schizophr Bull. 1990; 16: 379-390
- Computer generation of surface distribution maps of measurements of brain activity.Comput Biol Med. 1982; 12: 191-199
- Limbic/mesolimbic connections and the pathogenesis of schizophrenia.Biol Psychiatry. 1991; 30: 383-400
- Significance probability mapping: An aid in the topographic analysis of brain electrical activity.Electroencephalogr Clin Neurophysiol. 1981; 51: 455-462
- Neurophysiological studies of schizophrenia, mania and depression.in: Gruzelier J. Flor-Henry P. Hemisphere Asymmetries of Function in Psychopathology. Elsevier, New York1979: 189-222
- EEG power spectrum profile and structural CNS characteristics in schizophrenia.Biol Psychiatry. 1990; 27: 1331-1334
- Schizophrenia and EEG spectral analysis.Electroencephalogr Clin Neurophysiol. 1974; 36: 377-386
- Predominant sensorimotor area left hemisphere dysfunction in schizophrenia measured by brain electrical activity mapping.Biol Psychiatry. 1985; 20: 515-532
- EEG mapping of left hemisphere dysfunction during motor performance in schizophrenia.Biol Psychiatry. 1986; 21: 249-262
- Bilateral brain dysfunction during motor activation in type II schizophrenia measured by EEG mapping.Biol Psychiatry. 1988; 23: 295-311
- Psychomotor disturbances in psychiatric patients as a possible basis for new attempts at differential diagnosis and therapy.Eur Arch Psychiatry Neurol Sci. 1989; 239: 194-209
- Qualitative and quantitative EEG findings in schizophrenia.Schizophr Bull. 1977; 3: 61-79
- Abnormal EEG responses to photic stimulation in schizophrenic patients.Schizophr Bull. 1990; 16: 627-634
- Imaging of brain electrophysiologic activity: Applications in psychiatry.Gen Hosp Psychiatry. 1992; 14: 99-106
- Topographic maps of brain electrical activity—Practice and pitfalls.Biol Psychiatry. 1988; 23: 628-636
- EEG and medication response in schizophrenia.Schizophr Res. 1989; 2: 76
- Computed electroencephalographic activity mapping in schizophrenia—The resting state reconsidered.Arch Gen Psychiatry. 1987; 44: 514-517
- Computerized EEG in schizophrenia.Schizophr Bull. 1988; 14: 193-197
- Alpha frequency in schizophrenia: An association with enlarged cerebral ventricles.Am J Psychiatry. 1988; 145: 861-864
- A statistical approach to computerized EEG: Preliminary data on control subjects and epileptic patients.Brain Topogr. 1991; 1: 401-406
- Alpha rhythms.J Clin Neurophysiol. 1990; 7: 163-189
- Computerized EEG in schizophrenic patients.Biol Psychiatry. 1990; 28: 488-494
- Brain electrical activity mapping (BEAM) in schizophrenic patients.Arch Gen Psychiatry. 1983; 40: 719-728
- Altered topography of EEG spectral content in schizophrenia.Electroencephalogr Clin Neurophysiol. 1983; 38: 263-271
- Computed EEG in schizophrenics.Biol Psychiatry. 1986; 21: 1221-1225
- SPSS/PC + for the IBM PC/XT/AT.SPSS Inc, Chicago, IL1986
- Quantitative EEG: II. Frequency analysis and topographic mapping in clinical settings. 1988; 5: 45-85
- Statistical issues concerning computerized analysis of brainwave topography.Ann Neurol. 1986; 19: 493-494
- P3 in schizophrenia is affected by stimulus modality, response requirements, medication status, and negative symptoms.Arch Gen Psychiatry. 1989; 46: 1035-1044
- Cognitive event-related potential correlates of schizophrenia.Psychol Bull. 1986; 100: 43-66
- Computerized EEG profiles of haloperidol, chlorpromazine, clozapine and placebo in treatment resistant schizophrenia.Clin Electroencephalogr. 1987; 18: 124-135
- EEG topography in psychiatric diagnosis and drug treatment.Ann Clin Psychiatry. 1989; 1: 7-17
- Deviant cerebral functional topography as revealed by electrophysiology.in: Helmchen H. Henn F.A. Biological Perspectives of Schizophrenia. Wiley, New York1987: 237-253
- A selective review of biological markers in schizophrenia.Schizophr Bull. 1991; 17: 99-110
- Implications of normal brain development for the pathogenesis of schizophrenia.Arch Gen Psychiatry. 1987; 44: 660-669
- The price of psychotropic drugs: A neglected factor.Hosp Commun Psychiatry. 1983; 34: 531-535
- Frontal spectral EEG findings in acutely ill schizophrenics.Biol Psychiatry. 1987; 22: 1021-1024
- Psychological topographic EEG and CT scan correlates of frontal lobe function in schizophrenia.Psychiatry Res. 1989; 29: 137-149
Article info
Publication history
Received in revised form:
September 3,
1992
Received:
December 8,
1991
Footnotes
☆The work presented here was conducted at the Durham, NC, Department of Veterans Affairs Medical Center. The contents should not be taken to represent V.A. opinions or policy.
Identification
Copyright
© 1993 Published by Elsevier Inc.
User license
Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0) | How you can reuse
Elsevier's open access license policy

Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)
Permitted
For non-commercial purposes:
- Read, print & download
- Redistribute or republish the final article
- Text & data mine
- Translate the article (private use only, not for distribution)
- Reuse portions or extracts from the article in other works
Not Permitted
- Sell or re-use for commercial purposes
- Distribute translations or adaptations of the article
Elsevier's open access license policy