Advertisement
Brief report| Volume 34, ISSUE 1-2, P115-118, July 01, 1993

Preliminary report: Brain blood flow using PET in patients with posttraumatic stress disorder and substance-abuse histories

DOI:https://doi.org/10.1016/0006-3223(93)90264-E
Preliminary report: Brain blood flow using PET in patients with posttraumatic stress disorder and substance-abuse histories
Previous ArticleState specificity of DST abnormalities in geriatric depression
Next ArticleAntipsychotic drugs block phencyclidine receptor-mediated neurotoxicity
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Posttraumatic stress disorder (PTSD) is defined by DSM-III-R as an anxiety disorder characterized by recurrent distressing and intrusive remembrances of a traumatic event (American Psychiatric Association 1987). Some physiological abnormalities have been found in PTSD, notably for cardiac (Blanchard et al 1991) and neuroendocrine measures (Friedman 1991), but no studies to date have directly measured regional brain function changes in PTSD using positron emission tomography (PET).
      This preliminary study compares PTSD patients who have histories of substance abuse (Keane et al 1983, 1988) with normal controls who did not have a history of substance abuse. PET studies of anxiety disorders (Baxter et al 1987; Nordahl et al 1989, 1990; Reiman et al 1986), and acute (London et al 1990) and recent (Volkow et al 1991) substance abuse suggested hypotheses of increased orbital frontal cortex (OFC) blood flow and decreased left/right hippocampal ratios in PTSD patients with histories of substance abuse (PTSD-SA) compared to normal control subjects.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • American Psychiatric Association
        3rd ed. rev. Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Press, Washington, DC1987
        • Baxter L.R.
        • Phelps M.E.
        • Mazziotta J.C.
        • et al.
        Local cerebral glucose metabolic rates in obsessive-compulsive disorder.
        Arch Gen Psychiatry. 1987; 44: 211-218
        • Nanchard E.B.
        • Kolb L.C.
        • Prins A.
        Psychophysiological responses in the diagnosis of posttraumatic stress disorder in Vietnam Veterans.
        J Nerv Ment Dis. 1991; 179: 97-101
        • Buchsbaum M.S.
        • Ingvar D.H.
        • Kessler R.
        • et al.
        Cerebral glucography with positron tomography: Use in normal subjects and patients with schizophrenia.
        Arch Gen Psychiatry. 1982; 39: 251-259
        • Cohen R.M.
        • Semple W.E.
        • Gross M.
        • Holcomb H.
        • Dowling M.
        • Nordahl T.
        Functional localization of sustained attention: Comparison to sensory stimulation in the absence of instruction.
        Neuropsychiatry, Neuropsychol Behav Neurol. 1988; 1: 3-20
        • Friedman M.J.
        Biological approaches to the diagnosis and treatment of post-traumatic stress disorder.
        J Traumatic Stress. 1991; 4: 67-91
        • Harrison P.A.
        • Hoffman N.G.
        The Substance Use Disorders Diagnostic Schedule.
        The Ramsey Clinic, St. Paul, MN1985
        • Keane T.M.
        • Caddell J.M.
        • Martin B.
        • Zimmering R.T.
        • Fairbank J.A.
        Substance abuse among Vietnam veterans with post traumatic stress disorders.
        Bull Soc Psychol Addictive Behav. 1983; 2: 117-122
        • Keane T.M.
        • Gerardi R.J.
        • Lyons J.A.
        • Wolfe J.
        The interrelationship of substance abuse and posttraumatic stress disorder: Epidemiological and clinical considerations.
        in: Recent Developments in Alcoholism. Vol 6. Plenum, New York1988: 27-48
        • London E.D.
        • Cascella N.G.
        • Wong D.F.
        • et al.
        Cocaine-induced reduction of glucose utilization in human brain.
        Arch Gen Psychiatry. 1990; 47: 567-574
        • Nordahl T.E.
        • Benkelfat C.
        • Semple W.E.
        • et al.
        Cerebral glucose metabolic rates in obsessive compulsive disorder.
        Neuropsychopharmacology. 1989; 2: 23-28
        • Nordahl T.E.
        • Semple W.E.
        • Gross M.D.
        • et al.
        Cerebral glucose metabolic differences in patients with panic disorder.
        Neuropsychopharmacology. 1990; 3: 261-272
        • Reiman E.M.
        • Raichle M.E.
        • Robbins E.
        • et al.
        The application of PET to the study of panic disorder.
        Am J Psychiatry. 1986; 143: 469-477
        • Stuss D.T.
        • Benson D.F.
        The Frontal Lobes.
        Raven Press, New York1986
        • Volkow N.D.
        • Fowler J.S.
        • Wolf A.P.
        • et al.
        Changes in brain glucose metabolism in cocaine dependence and withdrawal.
        Am J Psychiatry. 1991; 148: 621-626

      Article info

      Publication history

      Received in revised form: November 6, 1992
      Received: December 7, 1991

      Identification

      DOI: https://doi.org/10.1016/0006-3223(93)90264-E

      Copyright

      © 1993 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX