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Original article| Volume 34, ISSUE 1-2, P75-83, July 01, 1993

Lithium lengthens the period of circadian rhythms in lesioned hamsters bearing SCN grafts

DOI:https://doi.org/10.1016/0006-3223(93)90259-G
Lithium lengthens the period of circadian rhythms in lesioned hamsters bearing SCN grafts
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      Abstract

      Lithium lengthens the free-running period of carcadian rhythms in a wide variety of organisms. The object of the present study was to examine the effects of lithium treatment on free-running activity rhythms in suprachiasmatic nuclei lesioned (SCN-X) hamsters that had recovered circadian rhythmicity following transplantation of fetal anterior hypothalamic grafts containing the suprachiasmatic nuclei (SCN). The animals were housed individually in cages equipped with running wheels, and locomotor activity was monitored using a computer-based data acquisition system. At the end of the behavioral tests, animals were anesthetized and perfused. Brain sections were immunostained for vasoactive intestinal peptide (VIP) and vasopressin-associated neurophysin (NP) to evaluate the extent of the lesion and the presence of a functional graft. In both intact and in SCN-X grafted animals, lithium lengthened the period of free running activity without affecting the amount of activity or the precision of the rhythm.

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      Article info

      Footnotes

      ☆This research was supported by NIH grants NS 08783 to JLS and NS 24292 to R.S. Preliminary reports of these data were presented at the First International Behavioral Neuroscience Conference, San Antonio, TX, May 1992.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(93)90259-G

      Copyright

      © 1993 Published by Elsevier Inc.

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