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Original article| Volume 34, ISSUE 1-2, P45-50, July 01, 1993

Lymphocyte β-adrenoceptors in social phobia

  • Murray B. Stein
    Correspondence
    Address reprint requests to Murray B. Stein, MD, Anxiety Disorders Research Program, St. Boniface General Hospital Research Centre, Room R2032, 351 Tache Avenue, Winnipeg, MB Canada R2H 2A6.
    Affiliations
    From the Department of Psychiatry and the Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Search for articles by this author
  • Lisa L. Huzel
    Affiliations
    From the Department of Psychiatry and the Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
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  • Suzanne M. Delaney
    Affiliations
    From the Department of Psychiatry and the Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
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DOI:https://doi.org/10.1016/0006-3223(93)90255-C
Lymphocyte β-adrenoceptors in social phobia
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      Abstract

      β-adrenergic receptor kinetics were measured in leukocytes from 17 drug-free, nondepressed patients with social phobia (generalized type) and 17 gender-matched and age-matched healthy controls. Binding was characterized using the highly specific β-adrenergic ligand [125I]pindolol (125IPIN). Contrary to some studies in panic disorder and many studies in depression, no significant difference was found in Bmax or Kd values between social phobic patients and controls. Neither severity of social phobic symptoms nor the severity of certain symptoms of β-adrenergic activation (i.e., tachycardia, tremor, blushing) influenced Bmax or Kd. To the extent that these peripheral indices can be considered reflective of central processes, these findings suggest that a simple defect in β-adrenoceptor number or affinity is unlikely to explain the pathophysiology of generalized social phobia.

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      References

        • American Psychiatric Association
        3rd ed. Diagnostic and Statistical Manual of Mental Disorder. American Psychiatric Press, Washington, DC1987
        • Aimes P.L.
        • Gelder M.G.
        • Shaw P.M.
        Social phobia: A comparative clinical study.
        Br J Psychiatry. 1983; 142: 174-179
        • Albus M.
        • Bondy B.
        • Ackenheil M.
        Adrenergic receptors on blood cells: Relation to the pathophysiology of anxiety.
        Clin Neuropharmacology. 1986; 9 (suppl): 359-361
        • Arango V.
        • Ernsberger P.
        • Marzuk P.M.
        • et al.
        Autoradiographic demonstration of increased serotonin 5-HT2 and β-Adrenergic receptor binding sites in the brain of suicide victims.
        Arch Gen Psychiatry. 1990; 47: 1038-1047
        • Aronson T.A.
        • Carasiti I.
        • McBane D.
        • Whitaker-Azmitia P.
        Biological correlates of lactate sensitivity in panic disorder.
        Biol Psychiatry. 1989; 26: 463-477
        • Beck A.T.
        • Ward C.H.
        • Mendelson M.
        • et al.
        An inventory for measuring depression.
        Arch Gen Psychiatry. 1961; 4: 561-571
        • Brodde O.-E.
        • Kretsh R.
        • Ikesono K.
        • Zerkowski H.-R.
        • Reidemeister J.C.
        Human β-adrenoceptors: Relation of myocardial and lymphocyte β-adrenoceptor density.
        Science. 1986; 231: 1584-1585
        • Brodde O.-E.
        • Beckeringh J.
        • Michel M.
        Human heart β-adrenoreceptors: A fair comparison with lymphocyte β-adrenoreceptors.
        TIPS. 1987; 8: 403-407
        • Brown S.-L.
        • Charney D.S.
        • Woods S.W.
        • Heninger G.R.
        • Tallman J.
        Lymphocyte β-adrenergic receptor binding in panic disorder.
        Psychopharmacology. 1988; 94: 24-28
        • Böyum A.
        Isolation of mononuclear cells and granulocytes from human blood.
        Scand J Clin Lab Invest. 1968; 21 (suppl): 77-79
        • Cox B.J.
        • Swinson R.P.
        • Shaw B.F.
        Value of the fear questionnaire in differentiating agoraphobia and social phobia.
        Br J Psychiatry. 1991; 159: 842-845
        • Extein I.
        • Tallman J.
        • Smith C.C.
        • Goodman F.K.
        Changes in lymphocyte β-adrenergic receptors in depression and mania.
        Psychiatry Res. 1979; 1: 191-197
        • Ebstein R.P.
        • Lerer B.
        • Shapira B.
        • Shemesh Z.
        • Moscovitch D.G.
        • Kindler S.
        Cyclic AMP second-messenger signal amplification in depression.
        Br J Psychiatry. 1988; 152: 665-669
        • Feldman R.D.
        β-adrenergic receptor alterations in hypertension: Physiological and molecular correlates.
        Can J Physiol Pharmacol. 1987; 65: 1666-1672
        • Gelernter C.S.
        • Stein M.B.
        • Tancer M.E.
        • Uhde T.W.
        An examination of syndromal validity and diagnostic subtypes in social phobia and panic disorder.
        J Clin Psychiatry. 1992; 53: 23-27
        • Gilman A.G.
        G proteins: transducers of receptor-generated signals.
        Annu Rev Biochem. 1987; 56: 615-649
        • Gorman J.M.
        • Liebowitz M.R.
        • Fyer A.J.
        • et al.
        Treatment of social phobia with atenolol.
        J Clin Psychopharmacol. 1985; 5: 298-301
        • Halper J.P.
        • Brown R.P.
        • Sweeney J.A.
        • Kocsis J.H.
        • Peter A.
        • Mann J.J.
        Blunted β-adrenergic responsivity of peripheral blood mononuclear cells in endogenous depression.
        Arch Gen Psychiatry. 1988; 47: 461-464
        • Heimberg R.G.
        • Hope D.A.
        • Dodge C.S.
        • et al.
        DSM-III-R subtypes of social phobia: Comparison of generalized social phobics and public-speaking phobis.
        J Nerve Ment Dis. 1990; 178: 172-179
        • Horn E.M.
        • Corwin S.J.
        • Seinberg S.F.
        • et al.
        Reduced lymphocyte stimulatory guanine nucleotide regulatory protein and β-adrenergic receptors in congestive heart failure and reversal with angiotensin converting enzyme inhibitor therapy.
        Circulation. 1988; 78: 1373-1379

      21. Huzel LL, Delaney SM, Stein MB (1993): Lymphocyte β-adrenergic receptors in panic disorder: Findings with a highly selective ligand and relationship to clinical parameters. J Anxiety Disord (in press).

        • Lerer B.
        • Ebstein R.P.
        • Shestatzy M.
        • et al.
        Cyclic AMP signal transduction in posttraumatic stress disorder.
        Am J Psychiatry. 1987; 144: 1324-1327
        • Levin A.P.
        • Sandberg D.
        • Stein J.
        • Liebowitz M.R.
        Public speaking in social phobic subtypes.
        in: New Research Presentation, American Psychiatric Association 142nd Annual Meeting, May 19891989
        • Liebowitz M.F.
        • Fyer J.
        • Gorman J.M.
        • Klein D.F.
        Social phobia: Review of a neglected anxiety disorder.
        Arch Gen Psychiatry. 1985; 42: 729-736
        • Liebowitz M.R.
        • Gorman J.M.
        • Fyer A.J.
        • et al.
        Pharmacotherapy of social phobia: An interim report of a placebo-controlled comparison of phenelzine and atenolol.
        J Clin Psychiatry. 1988; 49: 252-257
        • Liebowitz M.R.
        • Schneier F.
        • Campeas R.
        • et al.
        Phenelzine vs atenolol in social phobia: A placebo-controlled comparison.
        Arch Gen Psychiatry. 1992; 49: 290-300
        • Lowry O.H.
        • Rosebrough N.J.
        • Farr A.L.
        • Randall R.J.
        Protein measurements with the Folin phenol reagent.
        J Biol Chem. 1951; 193: 265-275
        • Maddock R.J.
        • Carter C.S.
        • Magliozzi J.R.
        • Gietzen D.W.
        Reduced lymphocyte β-adrenoceptor function in panic disorder with agoraphobia and changes with treatment.
        Biol Psychiatry. 1992; 31: 67A
        • Magliozzi J.R.
        • Gietzen D.
        • Maddock R.J.
        • et al.
        Lymphocyte β-adrenorecepor density in patients with unipolar depression and normal controls.
        Biol Psychiatry. 1989; 26: 15-25
        • Manhi H.K.
        G proteins: Implications for psychiatry.
        Am J Psychiatry. 1992; 149: 746-760
        • Mann J.J.
        • Brown R.P.
        • Halper J.P.
        • et al.
        Reduced sensitivity of lymphocyte beta-adrenergic receptors in patients with endogenous depression and psychomotor agitation.
        N Engl J Med. 1985; 313: 715-720
        • Marks I.M.
        • Mathews A.M.
        Brief standard self-rating for phobic patients.
        Behav Res Ther. 1979; 17: 263-267
        • Munson P.J.
        • Rodbard P.
        LIGAND, a vorsatile computerized approach for characterization of ligand-binding systems.
        Anal Biochem. 1980; 107: 220-239
        • Pandey G.N.
        • Dysken M.W.
        • Garver D.L.
        • Davis J.M.
        Changes in lymphocyte β-adrenergic receptor function in affective illness.
        Am J Psychiatry. 1979; 136: 675-678
        • Pandey G.N.
        • Pandey S.C.
        • Davis J.M.
        Peripheral adrenergic receptors in affective illness and schizophrenia.
        Pharmacol Toxicol. 1990; 3: 13-36
        • Papp L.A.
        • Gorman J.M.
        • Liebowitz M.R.
        • Fyer A.J.
        • Cohen B.
        • Klein D.F.
        Epinephrine infusions in patients with social phobia.
        Am J Psychiatry. 1988; 145: 733-736
        • Seeman P.
        • Ulpian C.
        • Wreggett K.A.
        • Wells J.W.
        Dopamine receptor parameters detected by [3H]spiperone depend on tissue concentration: Analysis and examples.
        J Neurochem. 1984; 43: 221-235
        • Spielberger C.D.
        • Gorsuch R.L.
        • Lushene R.E.
        State-Trait Anxiety (STAI) Manual. Consulting Psychologists Press, Palo Alto, CA1970
        • Spitzer R.L.
        • Williams J.B.W.
        Structured Clinical Interview for DSM-III-R.
        Biometrics Research Department, New York1988 (New York State Psychiatric Institute)
        • Watson D.
        • Friend R.
        Measurement of social-evaluative anxiety.
        J Consult Clin Psychol. 1969; 33: 448-457

      Article info

      Publication history

      Received in revised form: April 8, 1993
      Received: October 2, 1992

      Identification

      DOI: https://doi.org/10.1016/0006-3223(93)90255-C

      Copyright

      © 1993 Published by Elsevier Inc.

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