Original article| Volume 34, ISSUE 1-2, P45-50, July 01, 1993

Lymphocyte β-adrenoceptors in social phobia

  • Murray B. Stein
    Address reprint requests to Murray B. Stein, MD, Anxiety Disorders Research Program, St. Boniface General Hospital Research Centre, Room R2032, 351 Tache Avenue, Winnipeg, MB Canada R2H 2A6.
    From the Department of Psychiatry and the Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
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  • Lisa L. Huzel
    From the Department of Psychiatry and the Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
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  • Suzanne M. Delaney
    From the Department of Psychiatry and the Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
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      β-adrenergic receptor kinetics were measured in leukocytes from 17 drug-free, nondepressed patients with social phobia (generalized type) and 17 gender-matched and age-matched healthy controls. Binding was characterized using the highly specific β-adrenergic ligand [125I]pindolol (125IPIN). Contrary to some studies in panic disorder and many studies in depression, no significant difference was found in Bmax or Kd values between social phobic patients and controls. Neither severity of social phobic symptoms nor the severity of certain symptoms of β-adrenergic activation (i.e., tachycardia, tremor, blushing) influenced Bmax or Kd. To the extent that these peripheral indices can be considered reflective of central processes, these findings suggest that a simple defect in β-adrenoceptor number or affinity is unlikely to explain the pathophysiology of generalized social phobia.


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