Advertisement
Biological Psychiatry
Advanced searchSave search
Research Article| Volume 34, ISSUE 7, P498-501, October 01, 1993

Download started.

Ok

Evidence of increased non-adrenoceptor [3H]idazoxan binding sites in the frontal cortex of depressed suicide victims

  • J. Javier Meana
    Affiliations
    From the Department of Pharmacology, University of the Basque Country Medical School Leioa, Bizkaia, Spain
    Search for articles by this author
  • Fernando Barturen
    Footnotes
    Affiliations
    From the Department of Pharmacology, University of the Basque Country Medical School Leioa, Bizkaia, Spain
    Search for articles by this author
  • Iñaki Martin
    Affiliations
    From the Department of Pharmacology, University of the Basque Country Medical School Leioa, Bizkaia, Spain
    Search for articles by this author
  • Jesús A. García-Sevilla
    Correspondence
    Address reprint requests to Dr.J. A. García-Sevilla, Lab. Neurofarmacologia, Dept. Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Cra. Valldemossa Km 7.5, E-07071 Palma de Mallorca (Balears), Spain.
    Affiliations
    From the Department of Pharmacology, University of the Basque Country Medical School Leioa, Bizkaia, Spain

    the Laboratory of Neuropharmacology, Department of Fundamental Biology and Health Sciences, University of the Balearic Islands, Palma de Mallorca, Spain
    Search for articles by this author
  • Author Footnotes
    ∗ Current address: Department of Anaesthesiology, Cruces University Hospital, Bizkaia.
DOI:https://doi.org/10.1016/0006-3223(93)90243-7
Evidence of increased non-adrenoceptor [3H]idazoxan binding sites in the frontal cortex of depressed suicide victims
Previous ArticleCovariance of positive and negative symptoms during neuroleptic treatment in schizophrenia: A replication
Next ArticleMutation in the β amyloid precursor protein gene and schizophrenia
      This paper is only available as a PDF. To read, Please Download here.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Asakura M.
        • Tsukamoto T.
        • Imafuku J.
        • Matsui H.
        • Ino M.
        • Hasegawa K.
        Quantitative analysis of rat brain α2-receptors discriminated by [3H]clonidine and [3H]rauwolscine.
        Eur J Pharmacol. 1985; 106: 141-147
        • Bricca G.
        • Dontenwill M.
        • Molines A.
        • Feldman J.
        • Belcourt A.
        • Bousquet P.
        The imidazoline preferring receptor: Binding studies in bovine, rat and human brainstem.
        Eur J Pharmacol. 1989; 162: 1-9
        • Brown C.M.
        • MacKinnon A.C.
        • McGrath J.C.
        • Spedding M.
        • Kilpatrick A.T.
        α2-adrenoceptor subtypes and imidazoline-like binding sites in the rat brain.
        Br J Pharmacol. 1990; 99: 803-809
        • Convents A.
        • Convents D.
        • De Backer J.P.
        • De Keyser J.
        • Vauqelin G.
        High affinity binding of [3H]rauwolscine and [3H]RX781094 to α2 adrenergic receptors and non-stereoselective sites in human and rabbit brain cortex membranes.
        Biochem Pharmacol. 1989; 38: 455-463
        • De Lean A.
        • Munson P.J.
        • Rodbard D.
        Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay, and physiological dose-response curve.
        Am J Physiol. 1978; 235: E97-E102
        • De Vos H.
        • Convents A.
        • De Keyser J.
        • De Backer J.P.
        • Van Megen I.J.B.
        • Ebinger G.
        • Vauquelin G.
        Autoradiographic distribution of α2 adrenoceptors, NAIBS, and 5-HT1A receptors in human brain using [3H]idazoxan and [3H]rauwolscine.
        Brain Res. 1991; 566: 13-20
        • Ernsberger P.
        Heterogeneity of imidazole binding sites in brain: Proposed II and I2 subtypes.
        in: Third IBRO World Congress Neuroscience, Montréal, Canada1991 (abstract P41.8)
        • García-Sevilla J.A.
        • Guimón J.
        • García-Vallejo P.
        • Fuster M.J.
        Biochemical and functional evidence of supersensitive platelet α2-adrenoceptors in major affective disorder: Effect of long-term lithium carbonate treatment.
        Arch Gen Psychiatry. 1986; 43: 51-57
        • García-Sevilla J.A.
        The platelet α2-adrenoceptor as a potential biological market in depression.
        Br J Psychiatry. 1989; 154: 67-72
        • Göthert M.
        • Molderings G.J.
        Involvement of presynaptic imidazoline receptors in the α2-adrenoceptor-independent inhibition of noradrenaline release by imidazoline derivatives.
        Naunyn-Schmiedeberg's Arch Pharmacol. 1991; 343: 271-282
        • Meana J.J.
        • Barturen F.
        • García-Sevilla J.A.
        α2-adrenoceptors in the brain of suicide victims: Increased receptor density associated with major depression.
        Biol Psychiatry. 1992; 32: 471-490
        • Miralles A.
        • Olmos G.
        • Sastre M.
        • Barturen F.
        • Martín I.
        • García-Sevilla J.A.
        Discrimination and pharmacological characterization of I2-imidazoline sites with [3H]idazoxan and alpha-2 adrenoceptors with [3H]RX821002 (2-methoxy idazoxan) in the human and rat brains.
        J Pharmacol Exp Ther. 1993; 264: 1187-1197
        • Molderings G.J.
        • Hentrich F.
        • Göthert M.
        Pharmacological characterization of the imidazoline receptor which mediates inhibition of noradrenaline release in the rabbit pulmonary artery.
        Naunyn-Schmiedeberg's Arch Pharmacol. 1991; 344: 630-638
        • Motulsky H.J.
        • Ransnas L.A.
        Fitting curves to data using nonlinear regression: A practical and nonmathematical review.
        FASEB J. 1987; 1: 365-374
        • Olmos G.
        • Miralles G.
        • Barturen F.
        • García-Sevilla J.A.
        Characterization of brain imidazoline receptors in normotensive and hypertensive rats: Differential regulation by chronic imidazoline drug treatment.
        J Pharmacol Exp Ther. 1992; 260: 1000-1007
        • Piletz J.E.
        • Halaris A.
        • Saran A.
        • Marler M.R.
        Desipramane lowers tritiated para-aminoclonidine binding in platelets of depressed patients.
        Arch Gen Psychiatry. 1991; 48: 813-820
        • Tibiriça E.
        • Feldman J.
        • Mermet C.
        • Gonon F.
        • Bousquet P.
        An imidazoline-specific mechanism for the hipotensive effect of clonidine: A study with yohimbine and idazoxan.
        J Pharmacol Exp Ther. 1991; 256: 606-613
        • Wikberg J.E.S.
        • Uhlen S.
        Further characterization of the guinea pig cerebral cortex idazoxan receptor: Solublization, distinction from the imidazole site, and demonstration of cirazoline as an idazoxan receptor-selective drug.
        J Neurochem. 1990; 55: 192-203

      Article info

      Publication history

      Received in revised form: June 25, 1993
      Received: June 22, 1992

      Footnotes

      ☆This study was supported by DGICYT grant PM91-0069; FIS grant 93/0641 and Gobierno Vasco grant PVG9118.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(93)90243-7

      Copyright

      © 1993 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX