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Abstract
Growth hormone has been investigated in numerous studies involving patients with schizophrenia
but has been measured only by radioimmunoassay (RIA). There have been no consistent
abnormalities differentiating patients with schizophrenia from normal controls. In
the current study, growth hormone (GH) variants were measured by Western blotting
techniques, which resulted in the quantitation of 4 GH size variants: 27K (27,000
Daltons), 22K, 20K, and 17K. In the entire sample of 17 schizophrenic subjects, all
GH variants were significantly higher than in the 14 normal controls. While there
were no significant differences between the 2 groups in RIA GH values, the RIA values
were generally higher in the schizophrenic group. In a subset of 12 schizophrenic
patients whose RIA values were approximately equal to the controls, both the 27K and
22K GH variants remained significantly higher in the patient group. In the schizophrenic
group, none of the GH variants or RIA GH changed significantly after 1 week of treatment
with neuroleptic medication. These preliminary results suggest that certain GH forms
may be elevated in schizophrenia, but further studies are needed.
Keywords
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Article info
Publication history
Received in revised form:
June 24,
1993
Received:
June 22,
1992
Identification
Copyright
© 1993 Published by Elsevier Inc.
