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Abstract
Anorexia nervosa (AN) patients have a tendency to develop renin-angiotensin-aldosterone
(RAA) abnormalities caused by abnormal behaviors expressed over long periods of time.
Short-term dietary sodium intake is a known modulator of blood pressure response to
infused angiotensin II (A II) in normal subjects. Therefore AN patients and normal
gender-matched and age-matched controls were studied for vascular responses to exogenous
A II. Untreated AN patients needed significantly greater quantities of exogenous A
II to raise diastolic blood pressure (DBP) to over 20 mmHg for 30 min compared with
controls (12.1 ± 0.47 versus 7.6 ± 0.69 ng/kg/min, p < 0.01). The amount of A II required to raise DBP to over 20 mmHg in AN patients
in tests before and after completion of treatment (4.2 ± 0.33 months later) was significantly
different (12.1 ± 0.47 versus 8.1 ± 0.25 ng/kg/min, p < 0.01). There was no significant difference between AN patients following treatment
and controls. Our results indicate that it requires long time before decreased A II
responsiveness caused by chronic sodium depletion normalizes in AN patients.
Keywords
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Article info
Publication history
Received in revised form:
May 28,
1993
Received:
May 18,
1992
Identification
Copyright
© 1993 Published by Elsevier Inc.