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Research Article| Volume 34, ISSUE 6, P401-406, September 15, 1993

Vascular responses to angiotensin II in Anorexia nervosa

DOI:https://doi.org/10.1016/0006-3223(93)90185-G
Vascular responses to angiotensin II in Anorexia nervosa
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      Abstract

      Anorexia nervosa (AN) patients have a tendency to develop renin-angiotensin-aldosterone (RAA) abnormalities caused by abnormal behaviors expressed over long periods of time. Short-term dietary sodium intake is a known modulator of blood pressure response to infused angiotensin II (A II) in normal subjects. Therefore AN patients and normal gender-matched and age-matched controls were studied for vascular responses to exogenous A II. Untreated AN patients needed significantly greater quantities of exogenous A II to raise diastolic blood pressure (DBP) to over 20 mmHg for 30 min compared with controls (12.1 ± 0.47 versus 7.6 ± 0.69 ng/kg/min, p < 0.01). The amount of A II required to raise DBP to over 20 mmHg in AN patients in tests before and after completion of treatment (4.2 ± 0.33 months later) was significantly different (12.1 ± 0.47 versus 8.1 ± 0.25 ng/kg/min, p < 0.01). There was no significant difference between AN patients following treatment and controls. Our results indicate that it requires long time before decreased A II responsiveness caused by chronic sodium depletion normalizes in AN patients.

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      Article info

      Publication history

      Received in revised form: May 28, 1993
      Received: May 18, 1992

      Identification

      DOI: https://doi.org/10.1016/0006-3223(93)90185-G

      Copyright

      © 1993 Published by Elsevier Inc.

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