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Research Article| Volume 34, ISSUE 6, P386-391, September 15, 1993

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Quantified electroencephalographic correlates of depression in Alzheimer's disease

DOI:https://doi.org/10.1016/0006-3223(93)90183-E
Quantified electroencephalographic correlates of depression in Alzheimer's disease
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      Abstract

      While depression is one of the most frequent psychiatric problems among patients with probable Alzheimer's disease (AD), its mechanism is not well known. We performed quantified EEGs in a consecutive series of seven patients with mild dementia and depression, six patients with mild dementia and no depression, eight patients with moderate dementia and depression, and eight patients with moderate dementia and no depression. Regardless of the severity of dementia, depressed patients had a significantly higher percent theta in posterior brain areas. Moreover, depressed patients with mild AD showed a similar theta frequency as non-depressed patients with moderate AD. These findings suggest that the presence of depression may contribute to the qEEG changes of AD.

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      Article info

      Publication history

      Received in revised form: April 28, 1993
      Received: December 4, 1992

      Footnotes

      ☆This study was partially supported by a grant from the Sandoz Foundation.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(93)90183-E

      Copyright

      © 1993 Published by Elsevier Inc.

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