Advertisement
Biological Psychiatry
Advanced SearchSave search
Full length article| Volume 34, ISSUE 6, P386-391, September 15, 1993

Quantified electroencephalographic correlates of depression in Alzheimer's disease

DOI:https://doi.org/10.1016/0006-3223(93)90183-E
Quantified electroencephalographic correlates of depression in Alzheimer's disease
Previous ArticleAntihistone and anti-dsDNA autoantibodies in Alzheimer's disease and vascular dementia
Next ArticleHypothalamic-pituitary-adrenal axis activity and 1-year outcome in depression
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      While depression is one of the most frequent psychiatric problems among patients with probable Alzheimer's disease (AD), its mechanism is not well known. We performed quantified EEGs in a consecutive series of seven patients with mild dementia and depression, six patients with mild dementia and no depression, eight patients with moderate dementia and depression, and eight patients with moderate dementia and no depression. Regardless of the severity of dementia, depressed patients had a significantly higher percent theta in posterior brain areas. Moreover, depressed patients with mild AD showed a similar theta frequency as non-depressed patients with moderate AD. These findings suggest that the presence of depression may contribute to the qEEG changes of AD.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • American Psychiatric Association
        Diagnostic and Statistical Manual of Mental Disorders. 3rd ed revised. American Psychiatric Press, Washington, DC1987
        • Blackman R.B.
        • Tukey J.W.
        The Measurement of Power Spectra.
        Dover Publications, New York1958
        • Brenner R.P.
        • Ulrich R.F.
        • Spiker D.G.
        • Selabassi R.J.
        • Reynolds C.F.
        • Marin R.S.
        • Boller F.
        Computerized EEG spectral analysis in elderly normal, demented and depressed subjects.
        Electroenceph Clin Neurophysiol. 1986; 64: 483-492
        • Canter N.L.
        • Hallett M.
        • Growder J.H.
        Lecithin does not affect EEG spectral analysis of P300 in Alzheimer disease.
        Neurology. 1982; 32: 1260-1266
        • Coben L.A.
        • Danziger W.
        • Berg L.
        Frequency analysis of the resting awake EEG in mild senile dementia of Alzheimer type.
        Electroenceph Clin Neurophysiol. 1983; 55: 372-380
        • Coben L.A.
        • Danziger W.
        • Storandt M.A.
        A longitudinal EEG study of mild senile dementia of Alzheimer type: Changes at 1 year and 2.5 years.
        Electroenceph Clin Neurophysiol. 1985; 61: 101-112
        • Duffy F.H.
        • Albert M.S.
        • McAnulty G.
        Brain electrical activity in patients with presenile and senile dementia of Alzheimer type.
        Ann Neurol. 1984; 16: 439-448
        • Folstein M.
        • Folstein S.
        • McHugh P.
        Mini-mental state: a practical method for grading the cognitive state of patients for the clinician.
        J Psychiat Res. 1975; 12: 189-198
        • Gerson I.M.
        Average evoked response (AER) in the electroencephalographic diagnosis of normally aging brain: a practical application.
        Clin Electroenceph. 1976; 7: 77-90
        • Gordon E.B.
        Serial EEG studies in presenile dementia.
        B J Psychiat. 1968; 114: 779-780
        • Hamilton M.
        Development of a ratign scale for primary depressive illness.
        B J Soc Clin Psychol. 1967; 6: 278-296
        • Hughes C.P.
        A new clinical scale for the staging of dementia.
        B J Psychiat. 1982; 140: 556-572
        • Loreck D.J.
        • Folstein M.F.
        Depression in Alzheimer's Disease.
        in: Starkstein S.E. Robinson R.G. Depression in Neurological Diseases. The Johns Hopkins University Press, Baltimore1993
        • Luthringer R.
        • Minot R.
        • Toussaint M.
        • Dago K.T.
        • Soufflet L.
        • Macher J.P.
        Neurophysiological characterization of depressed patients suffering from a major depressive episode using 3D EEG and EPs Mapping techniques.
        Biol Psychiatry. 1992; 31: 73A
        • McKhann G.
        • Drachman D.
        • Folstein M.F.
        • Katzmann R.
        • Price D.
        • Stadlan E.
        Clinical diagnosis of Alzheimer's disease: Report of NINCDS-ADRDA work group under the auspices of the Department of Health and Human Service task force on Alzheimer's disease.
        Neurology. 1984; 34: 939-944
        • Pearson J.L.
        • Teri L.
        • Reifler B.V.
        Functional status and cognitive impairment in Alzheimer's patients with and without depression.
        J Am Geriatr Soc. 1989; 37: 1117-1121
        • Penttila M.
        • Partanen J.V.
        • Soininen H.
        • Riekkinen P.J.
        Quantitative analysis of occipital EEG in different stages of Alzheimer's disease.
        Electroenceph Clin Neurophysiol. 1985; 60: 1-6
        • Rovner B.W.
        • German P.S.
        • Brant L.J.
        Depression and mortality in nursing homes.
        JAMA. 1991; 265: 993-996
        • Spitzer R.L.
        • Williams J.B.
        • Gibbon M.
        • First M.B.
        User's Guide for the Structured Clinical Interview for DSM-III-R.
        American Psychiatric Press, Washington, DC1990
        • Stigby B.
        • Jóhannesson G.
        • Ingvar D.H.
        Regional EEG analysis and regional cerebral blood flow in Alzheimer's and Pick's disease.
        Electroenceph Clin Neurophysiol. 1981; 51: 537-547
        • Visser S.L.
        • Van Tilburg W.
        • Hooijer C.
        • Jonker C.
        • DeRijke W.
        Visual evoked potentials (VEPs) in senile dementia (Alzheimer type) and in non-organic behavioural disorders in the elderly: comparison with EEG parameters.
        Electroenceph Clin Neurophysiol. 1985; 60: 115-121
        • Wolfe N.
        • Katz D.
        • Albert M.L.
        Neuropsychological profile linked to low dopamine: in Alzheimer's disease, major depression and Parkinson's disease.
        J Neurol Neurosurg Psychiatry. 1990; 53: 915-917
        • Zubenko G.S.
        • Mossy J.
        Neurochemical correlates of major depression in primary dementia.
        Arch Neurol. 1990; 47: 209-214
        • Zweig R.M.
        • Ross C.A.
        • Hedreen J.
        The neuropathology of aminergic nuclei in Alzheimer's disease.
        Ann Neurol. 1988; 24: 233-242

      Article Info

      Publication History

      Received in revised form: April 28, 1993
      Received: December 4, 1992

      Footnotes

      ☆This study was partially supported by a grant from the Sandoz Foundation.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(93)90183-E

      Copyright

      © 1993 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2022 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX