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Abstract
While depression is one of the most frequent psychiatric problems among patients with
probable Alzheimer's disease (AD), its mechanism is not well known. We performed quantified
EEGs in a consecutive series of seven patients with mild dementia and depression,
six patients with mild dementia and no depression, eight patients with moderate dementia
and depression, and eight patients with moderate dementia and no depression. Regardless
of the severity of dementia, depressed patients had a significantly higher percent
theta in posterior brain areas. Moreover, depressed patients with mild AD showed a
similar theta frequency as non-depressed patients with moderate AD. These findings
suggest that the presence of depression may contribute to the qEEG changes of AD.
Keywords
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Article info
Publication history
Received in revised form:
April 28,
1993
Received:
December 4,
1992
Footnotes
☆This study was partially supported by a grant from the Sandoz Foundation.
Identification
Copyright
© 1993 Published by Elsevier Inc.