Antihistone and anti-dsDNA autoantibodies in Alzheimer's disease and vascular dementia

      This paper is only available as a PDF. To read, Please Download here.


      In order to evaluate their prevalence in senile dementias, serum titer of antibodies against histones and double stranded deoxyribonucleic acid (dsDNA) were measured by means of the ELISA test in patients suffering from vascular dementia (VD), presentile Alzheimer's disease (AD), and senile dementia of the Alzheimer's type (SDAT). Only three subjects out of 87 had dsDNA autoantibodies. On the contrary, VD and SDAT showed high titers of antibodies against histones when compared to healthy controls. A significant relationship was also found between antihistone serum titer and degree of dementia in AD. Results were not influenced by gender, age, or duration of illness. Presence of antihistone antibodies in dementias might reflect an alteration of membrane fluidity and integrity with leakage of nuclear immunogens or disturbances of immune functions, as frequently observed in dementia disorders.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Bahmanyar S.
        • Moreau-Dubois M.C.
        • Brown P.
        • Cathala F.
        • Gajdusek D.C.
        Serum antibodies to neurofilament antigens in patients with neurological and other diseases and in healthy controls.
        J Neuroimmunol. 1983; 5: 191-196
        • Blennow K.
        • Wallin A.
        • Uhlemann C.
        • Gottfries C.G.
        White-matter lesions on CT in patients with Alzheimer's disease: Relation t clinical symptomatology and vascular factors.
        Acta Neurol Scand. 1991; 83: 187-193
        • Canoso R.T.
        • Sise H.S.
        Chlorpromazine-induced lupus anticoagulant and associated immunological abnormalities.
        Am J Hematol. 1982; 13: 121-129
        • Canoso R.T.
        • deOliveira R.M.
        Characterization and specificity of chlorpromazine induced antinuclear antibodies.
        J Lab Clin Med. 1986; 108: 213-217
        • Canoso R.T.
        • de Oliveira R.M.
        • Nixon R.A.
        Neuroleptic-associated autoantibodies: A prevalence study.
        Biol Psychiatry. 1990; 27: 863-870
        • Cohen M.G.
        • Webb J.
        Antihistone antibodies in rheumatoid arthritis and Felty's syndrome.
        Arthritis Rheum. 1989; 32: 1319-1324
        • Costa O.
        • Monier J.L.
        Antihistone antibodies detected by ELISA and immunoblotting in systemic lupus erythematosus and rheumatoid arthritis.
        J Rheumatol. 1986; 13: 722-725
        • Deberdt R.
        • Van Hooren J.
        • Biesbrouck M.
        • Amery W.
        Antinuclear factor-positive mental depression. A single disease entity?.
        Biol Psychiatry. 1976; 11: 69-74
        • DeLisi L.E.
        • Wyatt R.J.
        Abnormal immune regulation in schizophrenic patients.
        Psychopharmacol Bull. 1982; 18: 158-163
        • Erkinjunnti T.
        Types of multi-infarct dementia.
        Acta Neurol Scand. 1987; 75: 391-399
        • Fields R.A.
        • Toubbeh H.
        • Searles R.P.
        • Bankhurst A.D.
        The prevalence of anticardiolipin antibodies in a healthy population and its association with antinuclear antibodies.
        J Rheumatol. 1989; 16: 623-625
        • Fillit H.M.
        • Luine V.N.
        • Reisberg B.
        • Amador R.
        • McEwen B.
        • Zabriskie J.B.
        Studies of the specificity of antibrain antibodies in Alzheimer's disease.
        in: Hutton J.T. Kenny A.D. Senile Dementia. Alan R. Liss, New York1985: 307-318
        • Folstein M.
        • Folstein S.
        • McHugh P.
        Mini Mental State. A practical method for grading the cognitive state of patient for the clinician.
        J Psychiatry Res. 1975; 12: 189-198
        • Gottfries C.G.
        • Bräne G.
        • Gullberg B.
        • Steen G.
        A new rating scale of dementia syndromes.
        Arch Gerontol. 1982; 1: 311-316
        • Hachinski V.C.
        • Iliff L.D.
        • Zilhka E.
        • et al.
        Cerebral blood flow in dementia.
        Arch Neurol. 1975; 32: 632-637
        • Hamilton M.
        A rating scale for depression.
        J Neurol Neurosurg Psychiatry. 1960; 23: 56-61
        • Hardin J.A.
        The lupus autoantigens and the pathogenesis of systemic lupus erythematosus.
        Arthritis Rheum. 1986; 29: 457-463
        • Ishii T.
        • Haga S.
        Immunoelectron microscopic localization of immunoglobulins in amyloid fibrils of senile plaques.
        Acta Neuropathol. 1976; 36: 243-249
        • Kingsley B.S.
        • Gaskin F.
        • Fu S.M.
        Human antibodies to neurofibrillary tangles and astrocytes in Alzheimer's disease.
        J Neuroimmunol. 1988; 19: 89-99
        • Lopez O.L.
        • Rabin B.S.
        • Huff F.J.
        • Rezek D.
        • Reinmuth O.M.
        Serum autoantibodies in patients with Alzheimer's disease and vascular dementia and in nondemented control subjects.
        Stroke. 1992; 23: 1078-1083
        • Maes M.
        • Bosmans E.
        • Suy E.
        • Vandervorst C.
        • Dejonckheere C.
        • Raus J.
        Antiphospholipid, antinuclear, Epstein-Barr and cytomegalovirus antibodies, and soluble interleukin-2 receptors in depressive patients.
        J Affective Disord. 1991; 21: 133-140
        • Manoussakis M.N.
        • Tzioufas A.G.
        • Silis M.P.
        • Pange P.J.E.
        • Goudevenos J.
        • Metsopoulos H.M.
        High prevalence of anticardiolipin autoantibodies in a healthy elderly population.
        Clin Exp Immunol. 1987; 69: 557-565
        • McKhann G.
        • Drachman D.
        • Folstein M.
        • Katzman R.
        • Price D.
        • Stadlan E.M.
        Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease.
        Neurology. 1984; 34: 939-944
        • McRae-Deguerce A.
        • Booj S.
        • Haglid K.
        • et al.
        Antibodies in cerebrospinal fluid of some Alzheimer disease patients recognize cholinergic neurons in the rat central nervous system.
        in: Proc Natl Acad Sci USA. 84. 1987: 9214-9218
        • Nandy K.
        Brain-reactive antibodies in aging and senile dementia.
        in: Katzman R. Terry R. Bick K. Alzheimer's Disease-Senile Dementia and Related Disorders. Raven Press, New York1978: 503-512
        • Nitsch R.M.
        • Blusztajn J.K.
        • Pittas A.G.
        • Slack B.E.
        • Growdon J.H.
        • Wurtman R.J.
        Evidence of a membrane defect in Alzheimer's disease brain.
        in: Proc Natl Acad Sci USA. 89. 1992: 1671-1675
        • Pelonero A.L.
        • Pandurangi A.K.
        • Calabrese V.P.
        Autoantibodies to brain lipids in schizophrenia.
        Am J Psychiatry. 1990; 147: 661-662
        • Presley A.P.
        • Kahn A.
        • Williamson N.
        Antinuclear antibodies in patients on lithium carbonate.
        Br Med J. 1976; ii: 280-281
        • Rogers J.
        • Luber-Narod J.
        • Styren S.D.
        • Civin W.H.
        Expression of immune system associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease.
        Neurobiol Aging. 1988; 9: 339-349
        • Scheltens P.
        • Barkhof F.
        • Algra P.
        • Valk J.
        • Gerritsen van der Hoop R.
        • Wolters E.
        White matter hyperintensities on magnetic resonance in Alzheimer's disease and normal aging.
        Neurobiol Aging. 1990; 11: 263
        • Shima S.
        • Yano K.
        • Sugiura M.
        • Tokunaga Y.
        Anticerebral antibodies in functional psychoses.
        Biol Psychiatry. 1991; 29: 322-328
        • Singh V.K.
        • Fudenberg H.H.
        Detection of brain autoantibodies in the serum of patients with Alzheimer's disease but not Down's syndrome.
        Immunol Lett. 1986; 12: 277-280
        • Sirota P.
        Is schizophrenia an autoimmune disease?.
        Isr J Med Sci. 1990; 26: 694-697
        • Skias D.
        • Bania M.
        • Reder A.T.
        • Luchins D.
        • Antel J.P.
        Senile dementia of Alzheimer's type (SDAT): reduced T8 + cell-mediated suppressor activity.
        Neurobiology. 1985; 35: 1635-1638
        • Tanaka J.
        • Murakoshi K.
        • Takeda M.
        A high level of anti-GFAP autoantibody in the serum of patients with Alzheimer's disease.
        Biomed Res. 1988; 9: 209-216
        • Villemain F.
        • Meguin M.
        • Feuillet-Fieux M.N.
        • Zarifian E.
        • Loo H.
        • Bach J.F.
        Anti-histone antibodies in schizophrenia and affective disorders.
        Psychiatry Res. 1987; 26: 53-60
        • Von Brauchitsch H.
        Antinuclear factor in psychiatric disorders.
        Am J Psychiatry. 1972; 128: 1552-1554
        • Wallin A.
        • Blennow K.
        • Gottfries C.G.
        • Langstrom G.
        • Uhlemann C.
        White matter low attenuation on computed tomography in Alzheimer's disease and vascular dementia.
        Acta Neurol Scand. 1989; 80: 518-523
        • Weinstein A.
        Lupus syndromes induced by drugs.
        in: Shur P.H. The Clinical Management of Systemic Lupus Erythematosus. Grune & Stratton, Boston1983: 312-324
        • Yannitsi S.G.
        • Manoussakis M.N.
        • Mavridis A.K.
        • et al.
        Factors related to the presence of autoantibodies in patients with chronic mental disorders.
        Biol Psychiatry. 1990; 27: 747-756
        • Zarrabi M.H.
        • Zucker S.
        • Miller F.
        Immunological and coagulation disorders in chlorpromazine-treated patients.
        Ann Intern Med. 1979; 91: 194-199