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Full length article| Volume 34, ISSUE 4, P226-233, August 15, 1993

Serum and saliva cortisol relations in adolescents during pregnancy and the early postpartum period

  • Lorah D. Dorn
    Correspondence
    Address reprint requests to Lorah D. Dorn, Ph.D., R.N., National Institutes of Health, Building 10/3 South-231, 9000 Rockville Pike, Bethesda, MD 20892.
    Footnotes
    Affiliations
    National Institutes of Health (LDD), Bethesda, MD, USA

    Biobehavioral Health Program, The Pennsylvania State University, University Park, PA, USA
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  • Elizabeth J. Susman
    Footnotes
    Affiliations
    National Institutes of Health (LDD), Bethesda, MD, USA

    Biobehavioral Health Program, The Pennsylvania State University, University Park, PA, USA
    Search for articles by this author
  • Author Footnotes
    ∗∗ The authors gratefully appreciate the support of Drs. Daryl Mayes and Greg Berg of Endocrine Sciences, Inc., in completing the serum and saliva assays, Dr. Anne C. Petersen for her continued support in this project, and Dr. George P. Chrousos for his helpful comments on an earlier draft of this paper.
DOI:https://doi.org/10.1016/0006-3223(93)90076-P
Serum and saliva cortisol relations in adolescents during pregnancy and the early postpartum period
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      Abstract

      The purpose of this investigation was to examine: (1) relations between serum and saliva cortisol in adolescents in pregnancy and early postpartum and (2) short-term consistency of serum and saliva cortisol across three samples, 20 minutes apart, as well as the long-term consistency from pregnancy to early postpartum.
      Pregnant adolescents (n = 40), ages 14 to 19years, were enrolled in this study. Subjects were seen at 20 weeks gestation or earlier (T1), 34–36 weeks gestation (T2), and 2–3 weeks postpartum (T3). Blood samples were drawn at T1 and T3, at 0, 20, and 40 minutes. Saliva samples were collected across the same 40-minute period at T1, T2, and T3. Spearman rho (rs) correlation coefficients between serum and saliva ranged from 0.72 to 0.77 (T1), and 0.42 to 0.60 (T3) (p ≤ 0.05). Short-term consistency between serum cortisol samples was 0.86–0.97 at T1 and 0.60–0.82 at T3. Short-term consistency for saliva cortisol samples was 0.70–0.96 at T1, 0.91–0.95 at T2, and 0.64–0.89 at T3. Long-term consistency (T1 to T3) for serum and saliva cortisol was low. Individual differences as well as dramatic changes in the endocrine environment in pregnancy and the early postpartum period may explain the more moderate serum-saliva correlations in the postportum period.

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      References

        • Ballard P.L.
        Delivery and transport of glucocorticoids to target cells.
        in: Baxter J.D. Rousseau G.G. Glucocorticoid Hormone Action. Springer, Berlin1979: 25-48
        • Bernutz C.
        • Hansle W.O.
        • Horn K.
        • et al.
        Isolation, characterization and radioimmunoassay of corticosteroid binding globulin (CBG) in human serum—clinical significance and comparison to thyroxine-binding globulin (TBG).
        Acta Endocrinol. 1979; 92: 370-384
        • Bober J.F.
        • Weller E.B.
        • Weller R.A.
        • Tait A.
        • Fristad M.A.
        • Preskorn S.H.
        Correlation of serum and salivary cortisol levels in prepubertal school-aged children.
        J Am Acad Child Adolesc Psychiatry. 1988; 27: 748-750
        • Brian T.G.
        • Dabrymphe I.J.
        A longitudinal study of the free cortisol index of pregnancy.
        Br J Obstet Gynaecol. 1976; 83: 361-367
        • Burke P.M.
        • Reichler R.J.
        • Smith E.
        • Dugaw K.
        • McCauley E.
        • Mitchell J.
        Correlation between serum and salivary cortisol levels in depressed and nondepressed children and adolescents.
        Am J Psychiatry. 1985; 142: 1065-1067
        • Bustamante B.
        • Crabbe J.
        Parotid saliva cortisol in normal subjects: increase during pregnancy.
        J Steroid Biochem. 1984; 20: 133-136
        • Carr B.R.
        • Parker C.R.
        • Madden J.D.
        • MacDonald P.C.
        • Porter O.
        Maternal plasma adrenocorticotropin and cortisol relationships throughout human pregnancy.
        Am J Obstet Gynecol. 1981; 139: 416-422
        • Costello A.J.
        • Edelbrock C.
        • Kalas R.
        • et al.
        Development and testing of the NIMH Diagnostic Interview Schedule for Children in a clinical population (Contract No. RFP-DB-81-0027).
        Center for Epidemiological Studies, NIMH, Rockville, MD1981
        • Dahl R.E.
        • Ryan N.D.
        • Puig-Antich J.
        • et al.
        24-hr cortisol measures in adolescents with major depression: a controlled study.
        Biol Psychiatry. 1991; 30: 25-36
        • Demey-Ponsart E.
        • Foidart J.M.
        • Sulon J.
        • Sodoyez J.C.
        Serum CBG, free and total cortisol and circadian patterns of adrenal function in normal pregnancy.
        J Steroid Biochem. 1982; 16: 156-169
        • Dorn L.D.
        • Susman E.J.
        • Petersen A.C.
        Cortisol reactivity and anxiety and depression in pregnant adolescents: a longitudinal perspective.
        Psychoneuroendocrinology. 1993; 18: 219-239
        • Ellis R.
        • Gulick D.
        Calculus with Analytic Geometry.
        Harcourt Brace Jovanovich, New York1978
        • Evans P.J.
        • Peters J.R.
        • Dyas J.
        • Walker R.F.
        • Riad-Fahmy D.
        • Hall R.
        Salivary cortisol levels in true and apparent hypercortisolism.
        Clin Endocrinol. 1984; 20: 709-715
        • Francis S.J.
        • Walker R.F.
        • Riad-Fahmy D.
        • Hughes D.
        • Murphy J.F.
        • Gray O.P.
        Assessment of adrenocortical activity in term newborn infants using salivary cortisol determinations.
        J Pediatr. 1987; 222: 129-133
        • Gold P.W.
        • Goodwin F.K.
        • Chrousos G.P.
        Clinical and biochemical manifestations of depression: relation to the neurobiology of stress (first of two parts).
        N Engl J Med. 1988; 319: 348-353
        • Gold P.W.
        • Goodwin F.K.
        • Chrousos G.P.
        Clinical and biochemical manifestations of depression: relation to the neurobiology of stress (second of two parts).
        N Engl J Med. 1988; 319: 413-420
        • Gunnar M.
        Psychobiological studies of stress and coping: an introduction.
        Child Dev. 1987; 58: 1403-1407
        • Hampl R.
        • Foretova L.
        • Sulcova J.
        • Starka L.
        Daily profiles of salivary cortisol in hydrocortisone treated children with congenital adrenal hyperplasia.
        Eur J Pediatr. 1990; 149: 232-234
        • Harris B.
        • Watkins S.
        • Cook N.
        • Walker R.F.
        • Read G.F.
        • Riad-Fahmy D.
        Comparisons of plasma and salivary cortisol determinations for the diagnostic efficacy of the dexamethasone suppression test.
        Biol Psychiatry. 1990; 27: 897-904
        • Jolivet A.
        • Blanchier H.
        • Gautray J.P.
        Blood cortisol variations during pregnancy and labor.
        Am J Obstet Gynecol. 1974; 119: 775-783
        • Kahn J.P.
        • Rubinow D.R.
        • Davis C.L.
        • Kling M.
        • Post R.M.
        Salivary cortisol: a practical method for evaluation of adrenal function.
        Biol Psychiatry. 1988; 23: 335-349
        • Kirschbaum C.
        • Steyer R.
        • Eid M.
        • Patalla U.
        • Schwenkmezger P.
        • Hellhammer D.H.
        Cortisol and behavior: 2. Application of latent state—trait model to salivary cortisol.
        Psychoneuroendocrinology. 1990; 15: 297-308
        • Klee S.H.
        • Garfinkel B.D.
        Identification of depression in children and adolescents: the role of the dexamethasone suppression test.
        J Am Acad Child Adolesc Psychiatry. 1984; 23: 410-415
        • Laudat M.H.
        • Cerdas S.
        • Fournier C.
        • Guiban B.
        • Gulhaume B.
        • Luton J.P.
        Salivary cortisol measurement: a practical approach to assess pituitary-adrenal function.
        J Clin Endocrinol Metab. 1988; 66: 343-348
        • Lauritzen C.
        • Klopper A.
        Estrogens and androgens.
        in: Fuchs F. Klopper A. Endocrinology of Pregnancy. 3rd ed. JB Lippincott, Philadelpia1983: 73-91
        • Layne D.S.
        • Meyer C.J.
        • Vaishwaner P.S.
        • et al.
        The secretion and metabolism of cortisol and aldosterone in normal and in steroid treated women.
        J Clin Endocrinol. 1962; 22: 107
        • Lowry R.J.
        • Behan D.
        • Linton E.A.
        CRH in pregnancy.
        in: Abstracts NICHD, NIMH and ADAMHA Conference, September 8–9, 1989Corticotropin Releasing Hormone (CRH): Relevance to Human Physiology and Pathophysiology. 1989
        • Margioris A.
        • Grino M.
        • Rabin D.
        • Chrousos G.P.
        Human placenta and the hypothalamic-pituitary-adrenal axis.
        in: Chrousos G.P. Loriaux D.L. Gold P.W. Mechanisms of Physical and Emotional Stress. Plenum Press, New York1989: 389-398
        • Peters J.R.
        • Walker R.F.
        • Riad-Fahmy D.
        • Hall R.
        Salivary cortisol assays for assessing pituitary-adrenal reverse.
        Clin Endocrinol. 1982; 17: 583-592
        • Peterson R.E.
        Cortisol.
        in: Fuchs F. Klopper A. Endocrinology of Pregnancy. 3rd ed. JB Lippincott, Philadelphia1983: 112-143
        • Price D.A.
        • Close G.C.
        • Fielding B.A.
        Age of appearance of circadian rhythm in salivary cortisol values in infancy.
        Arch Dis Child. 1983; 58: 454-456
        • Puig-Antich J.
        Sleep and neuroendocrine correlates of affective illness in childhood and adolescence.
        J Adolesc Health Care. 1987; 8: 505-529
        • Raynaud J.P.
        • Bouton M.M.
        • Moguilewsky M.
        • et al.
        Steroid hormone receptors and pharmacology.
        J Steroid Biochem. 1980; 12: 143-156
        • Reid J.D.
        • Intrieri R.C.
        • Susman E.J.
        • Beard J.L.
        The relationship of serum and salivary cortisol in a sample of healthy elderly.
        J Gerontol. 1992; 47: 176-179
        • Robertson M.E.
        • Stiefel M.
        • Laidlaw J.C.
        The influence of estrogen on the secretion, disposition and biologic activity of cortisol.
        J Clin Endocrinol. 1969; 19: 1381-1398
        • Rosenthal H.E.
        • Slaunwhite Jr., W.R.
        • Sandberg A.A.
        Transcortin: a corticosteroid-binding protein of plasma: cortisol and progesterone interplay and unbound levels of these steroids in pregnancy.
        J Clin Endocrinol Metab. 1969; 29: 352-367
        • Sasaki A.
        • Shinkawa O.
        • Margioris A.N.
        • et al.
        Immunoreactive corticotropin-releasing hormone in human plasma during pregnancy, labor, and delivery.
        J Clin Endocrinol Metab. 1987; 64: 224-229
        • Scott E.M.
        • McGarrigle H.H.G.
        • Lachelin G.C.L.
        The increase in plasma and saliva cortisol levels in pregnancy is not due to the increase in corticosteroid binding globulin level.
        J Clin Endocrinol Metab. 1990; 71: 639-644
      39. 2nd ed. SPSS-X User's Guide. McGraw-Hill, New York1985
        • Umeda T.
        • Hiramatsu R.
        • Iwaoka T.
        • Shimada T.
        • Miura F.
        • Sato T.
        Use of saliva for monitoring unbound free cortisol levels in serum.
        Clin Chim Acta. 1981; 110: 245-253
        • Vining R.F.
        • McGinley R.A.
        • Maksvytis J.J.
        • Ho K.Y.
        Salivary cortisol: a better measure of adrenal cortisol function than serum cortisol.
        Ann Clin Biochem. 1983; 20: 329-335
        • Woolston J.L.
        • Gianfredi S.
        • Gertner J.M.
        • Paugus J.A.
        • Mason J.W.
        Salivary cortisol: a non-traumatic sampling technique for assaying cortisol dynamics.
        J Am Acad Child Psychiatry. 1983; 22: 474-476

      Article Info

      Publication History

      Received in revised form: May 12, 1993
      Received: October 13, 1992

      Footnotes

      ☆The research was supported in part by grants from the National Center for Nursing Research, National Research Service Award (F31 NRO5965) to the first author, and the National Association for Pediatric Nurse Associates and Practitioners to both authors.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(93)90076-P

      Copyright

      © 1993 Published by Elsevier Inc.

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