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Population frequencies of the A1 allele at the dopamine D2 receptor locus

  • Cathy L. Barr
    Footnotes
    Affiliations
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA
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  • Kenneth K. Kidd
    Correspondence
    Address reprint requests to Kenneth K. Kidd, Department of Genetics, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06510.
    Footnotes
    Affiliations
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA
    Search for articles by this author
  • Author Footnotes
    ∗∗ Thanks to Gloria Schoolfield and Arlene Hing-Loh for providing excellent technical support, to Judith R. Kidd for help with the population DNA samples and for critical reading of the manuscript, and to Neil Risch and Joel Gelernter for helpful discussions.
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      Abstract

      The reported association of a polymorphic allele at the dopamine D2 receptor locus (DRD2) and alcoholism has recently been the focus of considerable interest and controversy. Evidence both for and against an association of the A1 allele of the TaqI A system have been reported. One of the inconsistencies in these studies is the frequency of the A1 allele in the controls. We undertook this study to determine the frequencies of the DRD2 A1 allele in different populations. The frequency of the DRD2 A1 allele was studied in 381 unrelated people from 16 different populations. On a global scale the frequency of the A1 allele was found to be dramatically different among the populations studied, from as low as 0.09 to as high as 0.75. Because of these significant differences an association study with this polymorphism must carefully control for ethnic origin of subjects and the results must be evaluated with caution.

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