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The total number of neurons was estimated in eight brains from chronic schizophrenic men and compared with 16 gender- and age-matched controls. The average total neocortical nerve cell number was 22.12·109 in schizophrenics and 22.06·109 in controls.
The estimate of total cell numbers can not demonstrate more subtle neuronal losses of specific cell types or cell loss in specific regions, but the result does not indicate that a major cell loss in the neocortex of schizophrenics is part of the disease.
The sampling scheme was based on a uniform sampling design, the counting was performed using new stereological principles and the majority of the cerebral cortex was left intact providing the possibility for resampling and further analysis.
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- Magnetic resonance imaging of the brain in schizophrenia.Arch Gen Psychiatry. 1990; 47: 35-44
- An analysis of the arrangement of neurons in the cingulate cortex of schizophrenic patients.Arch Gen Psychiatry. 1987; 44: 608-616
- Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics.Arch Gen Psychiatry. 1986; 43: 31-35
- Increased vertical axon numbers in cingulate cortex of schizophrenics.Arch Gen Psychiatry. 1987; 44: 1017-1021
- Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients.Arch Gen Psychiatry. 1991; 48: 996-1001
- The total number of neurons in the human neocortex unbiasedly estimated using optical disectors.J Microsc. 1990; 157: 285-304
- Brain morphology in schizophrenic disorder: Prevalence and correlates of diffuse (cortical and subcortical) brain atrophy.Psychiatry Res. 1989; 29: 257-259
- A consideration of neural counting methods.TINS. 1992; 15: 9-13
- The pathology of schizophrenia.Arch Neurol Psychiat. 1959; 81: 601-614
- Cell loss in the hippocampus of schizophrenics.Eur Arch Psychiatry Neurol Sci. 1986; 236: 154-161
- Computerized axial tomography scans and subtypes of schizophrenia. A review of the literature.J Nerv Ment Dis. 1986; 174: 31-41
- The new stereological tools: Disector, fractionator, nucleator, and point sampled intercepts and their use in pathological research and diagnosis.APMIS. 1988; 96: 857-881
- History of neuromorphometry.J Neurosci Meth. 1986; 18: 1-17
- Cortex, white matter, and basal ganglia in schizophrenia: A volumetric postmortem study.Biol Psychiatry. 1991; 29: 556-566
- Hippocampal neuron number in schizophrenia, a stereological study.Arch Gen Psychiatry. 1991; 48: 1002-1008
- Prenatal developmental disturbances in the limbic allocortex in schizophrenics.J Neural Transm. 1986; 65: 303-326
- Magnetic resonance imaging abnormalities in lenticular nuclei and cerebral cortex in schizophrenia.Arch Gen Psychiatry. 1991; 48: 881-890
- The spectrum of structural brain changes in schizophrenia: age of onset as a preductor of cognitive and clinical impairment and their cerebral correlates.Psychol Med. 1989; 19: 91-103
- Temporal lobe structure as determined by nuclear magnetic resonance in schizophrenia and bipolar affective disorder.J Neurol Neurosurg Psychiatry. 1989; 52: 736-741
- A study of the septum pellucidum and corpus callosum in schizophrenia with MR imaging.Acta Psychiatr Scand. 1985; 72: 414-421
- Major psychosis.in: Pathology of the Nervous System. 3. McGraw-Hill, New York1972: 2654-2665
- Post-mortem study of chronic schizophrenic brains.Br J Psychiatry. 1987; 151: 744-752
- Pronounced reduction of nerve cell number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics.Arch Gen Psychiatry. 1990; 47: 1023-1028
- Total number of neurons and glial cells in human brain nuclei estimated by the disector and the fractionator.J Microsc. 1988; 150: 1-20
- Total number of neurons in human neocortex related to age and sex estimated by way of optical disectors.Acta Stereologica. 1989; 8: 251-256
- Stereological quantitation of human brains from normal and schizophrenic individuals.Acta Neurol Scand. 1992; 137 (Suppl): 20-33
- Optimizing sampling designs for volume measurements of components of human brain using a stereological method.J Microsc. 1989; 155: 113-121
- Family history and brain morphology in schizophrenia: An MRI study.Psychiatry Res. 1991; 40: 49-60
- The unbiased estimation of number and sizes of arbitrary particles using the disector.J Microsc. 1984; 134: 127-136
- Neuropathological studies of schizophrenia: A selective review.Schizophr Bull. 1983; 9: 193-212
- The control of neuron number.Annu Rev Neurosci. 1988; 11: 423-453
Received in revised form: August 13, 1993
Received: December 4, 1992
© 1993 Published by Elsevier Inc.