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Abstract
The effect of an initial challenge with the serotonin (5-HT) uptake inhibitor clomipramine
(CMI) on subsequent rechallenge was studied in healthy men who served as volunteers.
Carefully screened volunteers were assigned to one of three conditions: (1) CMI challenge
followed 2 weeks later by CMI rechallenge; (2) placebo challenge followed 2 weeks
later by CMI challenge; and (3) CMI challenge followed 4 weeks later by CMI rechallenge.
We found significant blunting of the prolactin response to CMI rechallenge 2 weeks
(Signed Rank = −12, p = 0.05), but not 4 weeks after an initial challenge. Placebo
challenge did not affect CMI challenge 2 weeks later. These findings suggest that
a single exposure to IV CMI may cause 5-HT receptor changes that are present 2, but
not 4 weeks later. The ramifications of this finding with regard to the use of 5-HT
challenge paradigms in a test-retest design are discussed.
Keywords
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Article info
Publication history
Received in revised form:
August 5,
1993
Received:
June 11,
1992
Footnotes
☆Presented in part at the 47th Annual Meeting of the Society for Biological Psychiatry, Washington DC, April 30, 1992.
☆☆This research was supported in part by NIMH grants MH-42145, MH-19111, (MH-33127, and by NIH grant RR00046. Intravenous clomipramine (Anafranil) was provided by Ciba-Geigy.
Identification
Copyright
© 1993 Published by Elsevier Inc.
