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Research Article| Volume 32, ISSUE 6, P512-522, September 15, 1992

β-Adrenergic receptor binding in human and rat hypothalamus

  • Karley Y. Little
    Correspondence
    Address reprint requests to Dr. Karley E. Little, CB-7160, Medical School Wing B, Psychiatry Department, University of North Carolina, Chapel Hill, NC 27599.
    Footnotes
    Affiliations
    Department of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7160, USA

    Department of Mental Health Clinical Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7160, USA
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  • Gary E. Duncan
    Footnotes
    Affiliations
    Department of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7160, USA

    Department of Cell Biology and Anatomy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7160, USA

    Department of Brain and Development Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7160, USA

    Department of Mental Health Clinical Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7160, USA
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  • George R. Breese
    Footnotes
    Affiliations
    Department of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7160, USA

    Department of Brain and Development Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7160, USA

    Department of Mental Health Clinical Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7160, USA
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  • Walter E. Stumpf
    Footnotes
    Affiliations
    Department of Cell Biology and Anatomy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7160, USA

    Department of Brain and Development Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7160, USA
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  • Author Footnotes
    1 The authors gratefully acknowledge the assistance of the Office of the Chief Medical Examiner, State of North Carolina, John D. Butts, M.D., Chief, and the support of The Foundation of Hope for Research and Treatment of Mental Illness, Raleigh, N.C. and NIMH Grant MH-33127-12.
DOI:https://doi.org/10.1016/0006-3223(92)90219-P
β-Adrenergic receptor binding in human and rat hypothalamus
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      Abstract

      Quantitative autoradiographic analysis of β-adrenergic binding sites was conducted in human postmortem hypothalamus using the radioligand 125I-pindolol. The focus was on the hypothalamic nuclei most clearly involved in corticotropin-releasing hormone (CRH) release, the PVN and SON. For comparison, the distribution of hypothalamic β-adrenergic receptors was evaluated in the rat. A high level of β-adrenergic receptor binding was found in the human paraventricular nucleus (PVN) and supraoptic nucleus (SON), but not in the rat. The majority of the β-adrenergic receptors found in the human hypothalamus were of the β2-subtype. In contrast, in the rat hypothalamus, the majority of receptors were of the β1-subtype. These results show that the anatomical loci exist for direct β-adrenergic influence on hypothalamic neuroendocrine function in the human and that the topography of β-adrenergic receptors is markedly different in the rat and human hypothalamus.
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      Article info

      Publication history

      Received in revised form: May 15, 1992
      Received: September 23, 1991

      Footnotes

      ☆Presented in part at the 45th Annual Meeting of the Society of Biological Psychiatry, New York, NY, May 10, 1990

      Identification

      DOI: https://doi.org/10.1016/0006-3223(92)90219-P

      Copyright

      © 1992 Published by Elsevier Inc.

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