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Brief report| Volume 32, ISSUE 5, P457-461, September 01, 1992

Anger and anxiety responses to m-chlorophenylpiperazine in generalized anxiety disorder

  • Mark Germine
    Affiliations
    From the Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Yale University Department of Psychiatry, 34 Part Street, New Haven, Connecticut, USA

    the Yale University Department of Psychiatry, West Haven VA Medical Center, West Haven, Connecticut, USA
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  • Andrew W. Goddard
    Correspondence
    Address reprint request to Andrew W. Goddard, Abraham Ribicoff Research Facilities, 34 Park Street, New Haven, CT 06519.
    Affiliations
    From the Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Yale University Department of Psychiatry, 34 Part Street, New Haven, Connecticut, USA

    the Yale University Department of Psychiatry, West Haven VA Medical Center, West Haven, Connecticut, USA
    Search for articles by this author
  • Scott W. Woods
    Affiliations
    From the Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Yale University Department of Psychiatry, 34 Part Street, New Haven, Connecticut, USA

    the Yale University Department of Psychiatry, West Haven VA Medical Center, West Haven, Connecticut, USA
    Search for articles by this author
  • Dennis S. Charney
    Affiliations
    From the Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Yale University Department of Psychiatry, 34 Part Street, New Haven, Connecticut, USA

    the Yale University Department of Psychiatry, West Haven VA Medical Center, West Haven, Connecticut, USA
    Search for articles by this author
  • George R. Heninger
    Affiliations
    From the Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, Yale University Department of Psychiatry, 34 Part Street, New Haven, Connecticut, USA

    the Yale University Department of Psychiatry, West Haven VA Medical Center, West Haven, Connecticut, USA
    Search for articles by this author
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      References

        • Charney D.S.
        • Woods S.W.
        • Goodman W.K.
        • Heninger G.R.
        Serotonin function in anxiety II. Effects of the serotonin agonist MCPP in panic disorder and healthy subjects.
        Psychopharmacology. 1987; 92: 14-24
        • Charney D.S.
        • Woods S.W.
        • Heninger G.R.
        Noradrenergic function in generalized anxiety disorder: Effects of yohimbine in healthy subjects and patients with generalized anxiety disorder.
        Psychiatry Res. 1989; 27: 173-182
        • Curzon G.
        • Kennett G.A.
        m-CPP: A tool for studying behavioral responses associated with 5-HTIC receptors.
        Trends Pharmacolog Sci. 1990; 11: 181-182
        • Eleftheriou B.E.
        • Church R.L.
        Brain levels of serotonin and norepinephrine in mice after exposure to aggression and defeat.
        Physiol Behav. 1968; 3: 977-980
        • Germine M.
        • Goddard A.W.
        • Sholomskas D.E.
        • Heninger G.R.
        • Charney D.S.
        • Woods S.W.
        Specificity of anger response to m-CPP.
        in: Presented at the 145th Annual Meeting of the American Psychiatric Association, Washington, D.C.1992
        • Jenck F.
        • Broekkamp C.L.E.
        • VanDelft A.M.L.
        5-HT-1C receptors in the serotonergic control of periaqueductal gray induced aversion in rats.
        Psychopharmacology. 1990; 100: 372-376
        • Kahn R.S.
        • Wetzler S.
        • Van Praag H.M.
        • Asnis G.M.
        • Strauman T.
        Behavioral indications of serotonin hypersensitivity in panic disorder.
        Psychiatry Res. 1988; 25: 101-104
        • Kennett G.A.
        • Dickinson S.L.
        • Curzon G.
        Anxiogenic-like effects of MCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists.
        Eur J Pharmacol. 1989; 164: 445-454
        • Mellow A.M.
        • Lawlor B.A.
        • Sunderland T.
        • et al.
        Effects of daily oral m-chlorophenylpiperazine in elderly depressed patients.
        Biol Psychiatry. 1990; 28: 588-594
        • Moss H.B.
        • Yao J.K.
        • Panzak G.L.
        Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuse.
        Biol Psychiatry. 1990; 28: 325-338
        • Seibyl J.P.
        • Krystal J.H.
        • Price L.H.
        • et al.
        Effects of ritanserin on the behavioral, enuroendocrine and cardiovascular responses to m-chlorophenylpiperazine in healthy human subjects.
        Psychiatry Res. 1991; 38: 227-336
        • Siegel A.
        • Pott C.B.
        Neural substrates of aggression and flight in the cat.
        Prog Neurobiol. 1988; 31: 261-283