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Article| Volume 32, ISSUE 5, P426-437, September 01, 1992

Multidiagnostic evaluation of prolactin response to haloperidol challenge in schizophrenia: Maximal blunting in Kraepelinian patients

  • Nicholas A. Keks
    Correspondence
    Address reprint requests to Dr. N. Keks, Royal Park Hospital, Private Bag No. 3, Parkville, 3052, Victoria, Australia.
    Affiliations
    From the National Health and Medical Research Council Schizophrenia Research Unit, Mental Health Research Institute of Victoria and Monash University Department of Psychological Medicine, Royal Park Hospital, Parkville, Australia
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  • Dean P. McKenzie
    Affiliations
    From the National Health and Medical Research Council Schizophrenia Research Unit, Mental Health Research Institute of Victoria and Monash University Department of Psychological Medicine, Royal Park Hospital, Parkville, Australia
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  • Lee Hun Low
    Affiliations
    From the National Health and Medical Research Council Schizophrenia Research Unit, Mental Health Research Institute of Victoria and Monash University Department of Psychological Medicine, Royal Park Hospital, Parkville, Australia
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  • Patrick D. McGorry
    Affiliations
    From the National Health and Medical Research Council Schizophrenia Research Unit, Mental Health Research Institute of Victoria and Monash University Department of Psychological Medicine, Royal Park Hospital, Parkville, Australia
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  • Christine Hill
    Affiliations
    From the National Health and Medical Research Council Schizophrenia Research Unit, Mental Health Research Institute of Victoria and Monash University Department of Psychological Medicine, Royal Park Hospital, Parkville, Australia
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  • Jayashri Kulkarni
    Affiliations
    From the National Health and Medical Research Council Schizophrenia Research Unit, Mental Health Research Institute of Victoria and Monash University Department of Psychological Medicine, Royal Park Hospital, Parkville, Australia
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  • Bruce S. Singh
    Affiliations
    From the National Health and Medical Research Council Schizophrenia Research Unit, Mental Health Research Institute of Victoria and Monash University Department of Psychological Medicine, Royal Park Hospital, Parkville, Australia
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  • David L. Copolov
    Affiliations
    From the National Health and Medical Research Council Schizophrenia Research Unit, Mental Health Research Institute of Victoria and Monash University Department of Psychological Medicine, Royal Park Hospital, Parkville, Australia
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DOI:https://doi.org/10.1016/0006-3223(92)90130-R
Multidiagnostic evaluation of prolactin response to haloperidol challenge in schizophrenia: Maximal blunting in Kraepelinian patients
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      Abstract

      We have previously reported that prolactin (PRL) responses to haloperidol 0.5 mg IV were blunted in subjects characterized by several diagnostic systems of schizophrenia compared to controls (Keks et al 1990). However, an attempt to find a diagnostic system most different from controls was unsuccessful due to inherent difficulties in the statistical analysis of multidiagnostic data. In this paper we present new methodologies. A test for differences in dependent correlations demonstrated that most of the variance in stimulated PRL was accounted for by Kraepelinian, and least by Schneiderian and M. Bleulerian, schizophrenias (p < 0.001). The main symptomatic difference between nonKraepelinian and Kraepelinian patients was the presence of association disturbance and feelings of passivity. Patients with both symptoms had a lower stimulated PRL than controls. Further findings and possible implications are discussed.
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      Article info

      Publication history

      Received in revised form: February 25, 1992
      Received: March 23, 1991

      Identification

      DOI: https://doi.org/10.1016/0006-3223(92)90130-R

      Copyright

      © 1992 Published by Elsevier Inc.

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