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Research Article| Volume 32, ISSUE 9, P803-811, November 01, 1992

The prevalence of autoantibodies among right and left handed schizophrenic patients and control subjects

  • K.N.Roy Chengappa
    Footnotes
    Affiliations
    From the Department of Psychiatry (Immunopsychiatry Program), Western Psychiatric Institute & Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA

    Brain, Behaviour and Immunity Center, University of Pittsburgh, Carnegie Mellon University, Pittsburgh, Pennsylvania USA
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  • Rohan Ganguli
    Correspondence
    Address reprint requests to Rohan Ganguli, MD, FRCPC, Immunopsychiatry Program, Schizophrenia Module, Western Psychiatric Institute & Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213-2593 USA
    Footnotes
    Affiliations
    From the Department of Psychiatry (Immunopsychiatry Program), Western Psychiatric Institute & Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Pathology (Division of Immunopathology), University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania USA

    Brain, Behaviour and Immunity Center, University of Pittsburgh, Carnegie Mellon University, Pittsburgh, Pennsylvania USA
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  • Richard Ulrich
    Footnotes
    Affiliations
    From the Department of Psychiatry (Immunopsychiatry Program), Western Psychiatric Institute & Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
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  • B.S. Rabin
    Footnotes
    Affiliations
    From the Department of Psychiatry (Immunopsychiatry Program), Western Psychiatric Institute & Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA

    Department of Pathology (Division of Immunopathology), University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania USA

    Brain, Behaviour and Immunity Center, University of Pittsburgh, Carnegie Mellon University, Pittsburgh, Pennsylvania USA
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  • Joyce Cochran
    Footnotes
    Affiliations
    Brain, Behaviour and Immunity Center, University of Pittsburgh, Carnegie Mellon University, Pittsburgh, Pennsylvania USA
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  • J.S. Brar
    Footnotes
    Affiliations
    From the Department of Psychiatry (Immunopsychiatry Program), Western Psychiatric Institute & Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
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  • Zan W. Yang
    Footnotes
    Affiliations
    From the Department of Psychiatry (Immunopsychiatry Program), Western Psychiatric Institute & Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA

    Brain, Behaviour and Immunity Center, University of Pittsburgh, Carnegie Mellon University, Pittsburgh, Pennsylvania USA
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  • Marcia Deleo
    Footnotes
    Affiliations
    From the Department of Psychiatry (Immunopsychiatry Program), Western Psychiatric Institute & Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
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  • Author Footnotes
    1 The authors acknowledge Rosemarie Peria, M.S. for project coordination; Wendy Solomon M.P.M., and Colin Bachert B.S. for data management.
DOI:https://doi.org/10.1016/0006-3223(92)90083-C
The prevalence of autoantibodies among right and left handed schizophrenic patients and control subjects
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      Abstract

      Sera from schizophrenic patients (n = 186) and healthy control subjects (n = 346) were tested for the presence of seven common autoantibodies by standard immunological methods. The association between handedness and autoantibodies was tested in a multiway contingency table using a log-linear model. For men, but not women, nondextrals (patients and controls) were twice as likely to test positive for autoantibodies than dextrals (p = 0.0002). Although more women (33%) than men (24%) tested positive for autoantibodies, handedness was not a distinguishing factor among women. These data suggest that sinistrality and gender are associated with autoantibodies in a subgroup of schizophrenic patients and healthy control subjects.
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      Article info

      Publication history

      Received in revised form: July 10, 1992
      Received: November 16, 1991

      Footnotes

      ☆K.N.R.C. was supported in part by an NIMH Training Grant (MH 16804-10), RG is supported in part by an NIMH Research Scientist Development Award (MH 00710) and by a NARSAD Established Investigator Award. The work is also supported in part by an NIMH grant (MH 41883) to RG and BSR.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(92)90083-C

      Copyright

      © 1992 Published by Elsevier Inc.

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