Advertisement
Research Article| Volume 32, ISSUE 9, P778-789, November 01, 1992

Cardiovascular phase relationships to the cortical event-related potential of schizophrenic, depressed, and normal subjects

DOI:https://doi.org/10.1016/0006-3223(92)90081-A
Cardiovascular phase relationships to the cortical event-related potential of schizophrenic, depressed, and normal subjects
Previous ArticleContinuous physiological changes and subjective reports in panic patients: A preliminary methodological report
Next Articlelanguage comprehension in schizophrenics and their brothers
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Cardiovascular phase, especially diastole, influences attention and the event-related potential (ERP) of the right hemisphere of the brain. Depression and schizoprenia are characterized by attentional deficits, unique lateralization of brain function, and deviant phase relationships of biological oscillators. In the present study, the ERP was recorded during stimulation triggered by diastole and systole in control (n = 16), depressed (n = 16), and schizophrenic (n = 9) subjects. Fifty tones were presented and subjects were instructed to count them silently. Previous findings were supported of delayed latencies and increased amplitude in depressed patients and decreased amplitudes and delayed latencies in schizophrenics. An exaggerated effect of diastole on the ERP in the right hemisphere was observed in depressed patients, however, no cardiovascular effect on the ERP was apparent in schizophrenic patients. Results suggested that heart/brain networks are tightly coupled in normal controls, perhaps “overdriven” in depressed patients, and uncoupled in schizophrenics.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • American Heart Association (AHA)
        Advanced Cardiac Life Support. 1981;
        • Baribeau-Braum J.
        • Picton T.W.
        • Gosselin J.Y.
        Schizophrenia: A neurophysiological evaluation of abnormal information processing.
        Science. 1983; 219: 874
        • Birren J.
        • Cardon P.
        • Phillips S.
        Reaction time as a function of the cardiac cycle in young adults.
        Science. 1963; 140: 195-196
        • Buchsbaum M.S.
        Neurophysiological aspects of the schizophrenic syndrome.
        in: Belak L. The Schizophrenia Syndrome. Grune & Stratton, New York1979
        • Buchsbaum M.S.
        Neurophysiological reactivity, stimulus intensity modulation and the depressive disorders.
        in: Depue R. The Psychobiology of the Depression Disorders; Implication for the Effects of Stress. Academic Press, New York1979
        • Cacioppo J.T.
        • Sandman C.A.
        Physiological differentiation of sensory and cognitive tasks as a function of warning, processing demands and reported unpleasantness.
        Biol Psychol. 1978; 6: 181-192
        • Carpenter M.B.
        Core Text of Neuroanatomy.
        Waverly Press, Baltimore1972
      8. Carpenter D.O. Cellular Pacemakers. Volume 1: Mechanisms of Pacemaker Generation. Wiley, New York1982
      9. Carpenter D.O. Cellular Pacemakers. Volume 2: Function in Normal and Disease States. Wiley, New York1982
        • Connelly J.
        • Manchanda R.
        • Gruzelier J.
        • Hirsch S.
        Pathway and hemispheric differences in the event-related potential to monaural stimulation: A comparison of schizophrenic patients with normal controls.
        Biol Psychiatry. 1985; 20: 293-303
        • Davis G.C.
        • Buchsbaum M.S.
        • Bunney W.E.
        Alterations of evoked potentials link research in attention dysfunction to peptide response symptoms of schizophrenia.
        in: Costa E. Trabucci M. Neural Peptides and Neuronal Communication. Raven Press, New York1980
        • Desmedt J.E.
        • Bourguet M.
        • Nguyen T.H.
        • Delacuvellirie M.
        The P40 & P100 processing positivities that precede P300 closure in serial somatosensory decision tasks.
        Ann NY Acad Sci. 1984; 4253: 188-193
        • Flor-Henry P.
        The Cerebral Basis of Psychopathology.
        John Wright, Littleton, MA1983
        • Gruzelier J.H.
        Hemispheric imbalances in schizophrenia.
        Int J Psychophysiol. 1984; 1: 227-234
        • Hatfield B.
        • Landers D.
        • Ray W.
        Cardiovascular-CNS interactions during a self-paced, intentional attentive state: Elite marksmanship performance.
        Psychophysiology. 1987; 24: 542-549
        • Hugdahl K.
        • Franzon M.
        • Andersson B.
        • Walldebo G.
        Heart-rate responses (HRR) to lateralized visual stimuli.
        Pavlovian J Biol Sci. 1983; 18: 186-198
        • Kashima T.
        • Tanaka H.
        • Minagoe S.
        • Toda H.
        Electrocardiographic changes induced by the stellate ganglion block in normal subjects.
        J Electrocardiol. 1981; 14: 169-174
        • Kennedy J.L.
        A possible artifact in electroencephalography.
        Psychol Rev. 1959; 66: 347-352
        • Lacey J.I.
        Psychophysiological approaches to the evaluation of psychotherapeutic process and outcome.
        in: Rubinstein E. Parloff M.B. Research in Psychotherapy. American Psychological Association, Washington DC1959
        • Lacey J.I.
        Somatic response patterning and stress: Some revision of activation theory.
        in: Appley M.H. Trumbull R. Psychological Stress: Issues in Research. Appleton-Century-Crofts, New York1967: 14-37
        • Lacey B.C.
        • Lacey J.I.
        Studies of heart rate and other bodily processes in sensorimotor behavior.
        in: Obrist P.A. Black A. Brener J. DiCara L. Cardiovascular Psychophysiology. Aldine, Chicago1974
        • Lacey J.I.
        • Kagan J.
        • Lacey B.C.
        • Moss H.
        The visceral level: Situational determinants and behavioral correlates of autonomic response patterns.
        in: Black P.H. Expression of the Emotions in Man. International Universities Press, New York1963
        • Peronnet F.
        • Michel F.
        The asymmetry of the auditory evoked potentials in normal man and in patients with brain lesions.
        in: Auditory Evoked Potentials in Man. Psychopharmacology Correlates of EPs. Progress in Clinical Neurophysiology. 2. 1977: 130-141
        • Picton T.
        • Hillyard S.
        Human auditory evoked potentials II: Effects of attention.
        Electroencephalogr Clin Neurophysiol. 1977; : 191-196
        • Picton T.
        • Hillyard S.A.
        • Krausz H.
        • Galambos R.
        Human auditory evoked potentials I; Evaluations of components.
        Electroencephalogr Clin Neurophysiol. 1974; 36: 179-190
        • Plooij-van-Gorsel E.
        Evoked potential correlates of information processing and habituation in depressive illness.
        Ann NY Acad Sci. 1984; 425: 609-616
        • Roth W.T.
        • Cannon E.H.
        Some features of the AER in schizophrenics.
        Arch Gen Psychiatry. 1972; 27: 466-471
        • Saari M.
        • Pappas B.
        Cardiac cycle phase and movement and reaction times.
        Percept Mot Skills. 1976; 42: 767-770
        • Sandman C.A.
        Augmentation of the auditory event related potential of the brain during diastole.
        Int J Psychophysiol. 1984; 2: 111-119
        • Sandman C.A.
        • McCanne T.R.
        • Kaiser D.N.
        • Diamond B.
        Heart rate and cardiac phase influences on visual perception.
        J Comp Physiol Psychol. 1977; 91: 189-202
        • Sandman C.A.
        • Walker B.B.
        • Berka C.
        Influence of afferent cardiovascular feedback on behavior and the cortical evoked potential.
        in: Cacioppo J.T. Petty R.E. Perspectives in Cardiovascular Psychophysiology. Guilford Press, New York1982: 189-222
        • Sandman C.A.
        • Gerner R.H.
        • O'Halloran J.P.
        • Isenhart R.
        Preliminary studies of the neurophysiological and cognitive efficiency of schizophrenic, depressed, and alcoholic patients.
        Int J Psychophysiol. 1987; 5: 215-225
        • Schandry R.
        • Sparrer B.
        • Weitkunat R.
        From the heart to the brain: a study of heartbeat contingent scalp potentials.
        Int J Neurosci. 1986; 30: 261-275
        • Shagrass C.
        • Schwartz M.
        Evoked potential studies in psychiatric patients.
        Ann NY Acad Sci. 1964; 112: 526-542
        • Shagass C.
        • Straumanis J.J.
        • Roemer R.
        • Amadeo M.
        Evoked potentials of schizophrenics in several sensory modalities.
        Biol Psychiatry. 1977; 12: 221
        • Shagras C.
        • Roener R.A.
        • Straumanis Jr., J.L.
        • Amadeo M.
        Topography of sensory evoked potentials in depressive disorders.
        Biol Psychiatry. 1980; 15: 183-207
        • Walker B.B.
        • Sandman C.A.
        Human visual evoked responses are related to heart rate.
        J Comp Physiol Psychol. 1979; 93: 717-729
        • Walker B.B.
        • Sandman C.A.
        Visual evoked potentials change as heart rate and carotid pressure change.
        Psychophysiology. 1982; 19: 520-527
        • Walker B.B.
        • Walker M.
        Phase relations between carotid pressure and ongoing electrocortical activity.
        Int J Psychophysiol. 1983; 1: 65-73
        • Wehr T.
        • Goodwin F.
        Circadian Rhythms in Psychiatry.
        the Boxwood Press, Pacific Grove, CA1983
        • Winfree A.T.
        When Time Breaks Down.
        Princeton University Press, Princeton1987
        • Winfree A.T.
        The Timing of Biological Clocks.
        Scientific American Library, New York1987
        • Wong R.K.S.
        • Schwartzkroin P.A.
        Pacemaker neurons in the mammalian brain: mechanisms and function.
        in: Cellular Pacemakers Volume 1: Mechanisms of Pacemaker Generation. Wiley, New York1982: 237-254

      Article info

      Publication history

      Received in revised form: July 7, 1992
      Received: March 8, 1990

      Identification

      DOI: https://doi.org/10.1016/0006-3223(92)90081-A

      Copyright

      © 1992 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX