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Abstract
Levels of acute phase and other plasma proteins were measured in 21 men with major
depression, 28 men with alcohol dependence, and 12 men who acted as controls. The
depressed men had significantly elevated levels of the acute phase proteins, haptoglobin
and alpha-1-antichymotrypsin, and of immunoglobulin G. The elevations in haptoglobin
and alpha-1-antichymotrypsin were highly correlated with each other, and were correlated
with the severity of depression and negatively correlated with the thyroid stimulating
hormone response to thyrotropin. The alcoholic men had elevated haptoglobin levels,
but significantly decreased levels of immunoglobulin G. These findings provide further
evidence for an inflammatory response during depression.
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Article info
Publication history
Received:
April 23,
1991
Footnotes
☆This project was funded by grants from the Medical Research Council of New Zealand and the Alcoholic Liquor Advisory Council.
Identification
Copyright
© 1992 Published by Elsevier Inc.
