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Research Article| Volume 32, ISSUE 11, P1012-1018, December 01, 1992

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Familial subtypes of unipolar depression: A prospective study of familial pure depressive disease compared to depression spectrum disease

  • George Winokur
    Correspondence
    Address reprint requests to George Winokur, M.D., Department of Psychiatry, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
    Affiliations
    From the Department of Psychiatry, College of Medicine, University of Iowa, Iowa City, IA, USA
    Search for articles by this author
  • William Coryell
    Affiliations
    From the Department of Psychiatry, College of Medicine, University of Iowa, Iowa City, IA, USA
    Search for articles by this author
DOI:https://doi.org/10.1016/0006-3223(92)90062-5
Familial subtypes of unipolar depression: A prospective study of familial pure depressive disease compared to depression spectrum disease
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      Abstract

      In a large multicenter effort, major depressives were systematically studied at index admission and prospectively followed up for 5 years. Primary unipolar depressives with a family history of alcoholism (depression spectrum disease) differ from depressives with a family history of depression only (familial pure depressive disease) in having more familial anxiety and somatization disorder, more divorce, more suicide attempts, more negative life events, and needed more time to recover from the index episode. In the 5-year follow-up they are more likely to develop alcoholism and drug abuse. Depressive spectrum disease patients are more likely to meet systematic criteria for neurotic depression. The data suggest that major depression is a syndrome that is heterogeneous, and may be a final common pathway of more than one familial illnesses.
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      Article info

      Publication history

      Received in revised form: August 4, 1992
      Received: December 11, 1991

      Identification

      DOI: https://doi.org/10.1016/0006-3223(92)90062-5

      Copyright

      © 1992 Published by Elsevier Inc.

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