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Research Article| Volume 32, ISSUE 11, P976-991, December 01, 1992

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Mescaline-induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: Experimental psychosis as a tool for psychiatric research

DOI:https://doi.org/10.1016/0006-3223(92)90059-9
Mescaline-induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: Experimental psychosis as a tool for psychiatric research
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      Abstract

      The psychological, neuropsychological, and neurometabolic effects of the hallucinogenic agent mescaline were investigated in 12 normal men who were volunteers. Mescaline produced an acute psychotic state Math Eq hr after drug intake, as measured by the Brief Psychiatric Rating Scale (BPRS) and Paranoid Depression Scale (PDS). The Assessment of Altered States of Consciousness (APZ) questionnaire revealed specific effects of mescaline in the visual system. Neuropsychological effects were studied with a face/nonface decision task with known right-hemisphere advantage, in which mescaline induced a decrease of functioning of the right hemisphere. In functional brain imaging using single photon emission computed tomography (SPECT), mescaline produced a “hyperfrontal” pattern with an emphasis on the right hemisphere, which was correlated with mescaline-induced psychotic psychopathology. Our findings question the validity of the concept of hypofrontality as an explanation for schizophrenic symptomatology. The study of psychoactive substances under controlled laboratory conditions has the methodological advantage of intraindividual control, and hence, minimal variability of data.
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      References

        • Beaumont J.G.
        • Diamond S.J.
        Brain disconnection and schizophrenia.
        Br J Psychiatry. 1973; 123: 661-662
        • Beringer K.
        Der Meskalinrausch. Seine Geschichte und Erscheinungsweise.
        Monographie Neurol Psychiatry H. 1927; 49
        • Brodie J.D.
        • Christman D.R.
        • Corona J.F.
        Patterns of metabolic activity in the treatment of schizophrenia.
        Ann Neurol. 1984; 15 (suppl): 166-169
        • Buchsbaum M.S.
        • DeLisi L.E.
        • Holcomb H.H.
        • Hazlett E.
        • Cooper-Langston K.
        • Kessler R.
        Positron emission tomography studies of basal ganglia and somatosensory cortex neuroleptic drug effects: differences between normal controls and schizophrenic patients.
        Biol Psychiatry. 1987; 22: 479-494
        • Chapman J.
        The early symptoms of schizophrenia.
        Br J Psychiatry. 1966; 112: 225-251
        • Cutting J.
        The Psychology of Schizophrenia.
        Churchill Livingstone, Edinburgh, London, Melbourne, New York1985
        • Cutting J.
        The Right Cerebral Hemisphere and Psychiatric Disorders.
        Oxford University Press, Oxford1990
        • DeLisi L.E.
        The use of positron emission tomography (PET) to image regional brain metabolism in schizophrenia and other psychiatric disorders: a review.
        in: The Neurology of Schizophrenia. Handbook of Schizophrenia. vol I. Elsevier, Amsterdam, New York, Oxford1986
        • Dittrich A.
        • Arx S.von
        • Staub S.
        • Cochrane R.
        • Cordero M.
        • Davenport D.
        • et al.
        German J Psychol. 1985; 9 (In collaboration with Co): 319-339
        • Fahrenberg J.
        • Selg H.
        • Hampel R.
        Das Freiburger Persönlichkeitsinventar FPI-R.
        1984 (Hogrefe: Göttingen)
        • Farkas T.
        • Wolf A.P.
        • Jaeger J.
        • Brodie J.D.
        • Christman D.R.M.
        • Fowler J.S.
        Regional brain glucose metabolism in chronic schizophrenia: a positron emission transaxial tomographic study.
        Arch Gen Psychiatry. 1984; 41: 293-300
        • Fischman L.G.
        Dreams, hallucinogenic drug states and schizophrenia: A psychological and biological comparison.
        Schizophr Bull. 1982; 9: 73-94
        • Flor-Henry P.
        Psychosis and temporal lobe epilepsy: A controlled investigation.
        Epilepsia. 1969; 10: 363-395
        • Gruzelier J.H.
        Funktionelle Hemisphärenasymmetrien bei Schizophrenen.
        in: Hopf A. Beckmann H.(Hrsg) Forschungen zur biologischen Psychiatrie. Springer Valag, Springer, Berlin Heidelberg New York1984: 3-17
        • Gur R.E.
        • Resnick S.M.
        • Alavi A.
        • et al.
        Regional brain function in schizophrenia.
        Arch Gen Psychiatry. 1987; 44: 119-125
        • Gur R.E.
        • Resnick S.M.
        • Alavi A.
        • et al.
        Regional brain function in schizophrenia.
        Arch Gen Psychiatry. 1987; 44: 126-129
        • Guttmann E.
        • Maclay W.S.
        Mescaline and depersonalization.
        J Neurol Psychopathol. 1936; 83: 193-212
        • Hermle L.
        • Oepen G.
        • Spitzer M.
        Zur Bedeutung der Modellpsychosen.
        Fortsch Neurol Psychiat. 1988; 56: 48-58
        • Hermle L.
        • Spitzer M.
        • Kovar K.A.
        • Borchard D.
        • Gouzoulis E.
        Psychological effects of 3,4-methylenedioxyethamphetamine (MDE, “Eve”) in normal subjects: Are entactogenes a new class of psychoactive agents?.
        Neuropsychopharmacology. 1992; (in press)
        • Hoffer A.
        • Osmond H.
        Some psychological consequences of perceptual disorder and schizophrenia.
        Int J Neuropsychiatry. 1966; 2: 1-19
        • Ingvar D.H.
        “Hyperfrontal” distribution of the cerebral grey matter flow in resting wake-fulness, on the functional anatomy of the conscious state.
        Acta Neurol Scand. 1979; 60: 12-25
        • Ingvar D.H.
        • Franzen G.
        Distribution of cerebral activity in chronic schizophrenia.
        Lancet. 1974; 2: 1484-1486
        • Kinsbourne M.
        The cerebral basis of lateral asymmetries in attention.
        Acta Psychologica. 1970; 33: 193-201
        • Kling A.S.
        • Metter E.J.
        • Riege W.H.
        • Kuhl D.E.
        Comparison of PET measurement of local brain glucose metabolism and CAT Measurement of brain atrophy in chronic schizophrenia and depression.
        Am J Psychiatry. 1986; 143: 175-180
        • Leenders K.L.
        PET in der Biologischen Psychiatrie.
        in: Saletu B. Biolgische Psychiatrie. Thieme, Stuttgart New York1989: 69-76
        • Magaro P.A.
        • Page J.
        Brain disconnection, schizophrenia and paranoia.
        J Ment Nerv Dis. 1983; 171: 133-140
        • Musalek M.
        • Podreka I.
        • Suess E.
        • et al.
        Neurophysiological aspects of auditory hallucinations.
        Psychopathology. 1988; 21: 275-280
        • Nasrallah H.A.
        Cerebral hemisphere asymmetries and interhemispheric integration in schizophrenia.
        in: Nasrallah H.A. Weinberger D.R. The Neurology of schizophrenia. Handbook of Schizophrenia. vol 1. Science Publishers, Amsterdam, Oxford, New York1986: 157-174 (Elsevier)
        • Oepen G.
        • Fünfgeld M.
        • Höll T.
        • Zimmermann P.
        • Landis T.
        • Regard M.
        Schizophrenia—an emotional hypersensitivity of the right cerebral hemisphere.
        Int J Psychophysiol. 1988; 5: 261-264
        • Oldfield R.C.
        The assessment and analysis of handedness. The Edinburgh inventory.
        Neuropsychologia. 1971; 9: 97-113
        • Overall J.E.
        • Gorham D.R.
        Brief Psychiatric Rating Scale.
        in: rev. ed. W ECDEU Assessment Manual for Psychopharmacology. 1976: 157-169 (Rockville, MD)
        • Podreka I.
        • Suess E.
        • Goldenberger G.
        • et al.
        Initial experience with Tc-99m-hexamethylpropylene-amine oxime (Tc-99m-HMPAO) brain SPECT.
        J Nucl Med. 1987; 27: 1657-1666
        • Regard M.
        • Landis T.
        Affective and cognitive decisions on faces in normals.
        in: Ellis H.D. Jeeves M.A. Newcombe F. Young A. Aspects of Face Processing. Martin Nijhoff, Dordrecht1986: 363-369
        • Schweitzer L.
        • Becker E.
        • Welsh E.
        Abnormalities of cerebral lateralization in schizophrenia patients.
        Arch Gen Psychiatry. 1978; 35: 982-985
        • Sharp P.F.
        • Smith F.W.
        • Gemmell H.G.
        • et al.
        Technetium-99-m-HMPAO stereoisomers as potential agents for imaging regional cerebral blood flow: human volunteer studies.
        J Nucl Med. 1986; 27: 171-177
        • Sheppard G.
        • Gruzelier J.
        • Manchanda R.
        • et al.
        15-O-positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients.
        Lancet. 1983; II: 1448-1452
        • Tormer R.
        • Mintz M.
        • Myslobodsky M.S.
        Left hemisphere hyperactivity in schizophrenia: Abnormality inherent to psychosis or to neuroleptic side-effects?.
        Psychopharmacology. 1982; 77: 168-170
        • Venables P.H.
        Cerebral mechanisms, autonomic responsiveness and attention in schizophrenia.
        in: Spaulding W.D. Cole J.K. Theories in schizophrenia and psychosis. University of Nebraska Press, Lincoln1984Nebraska Symposium on Motivation. 1983; vol 31: 47-91
        • West E.D.
        Right hemisphere dysfunction and schizophrenia.
        Lancet. 1984; 11: 344
        • Wiesel F.A.
        • Blomquist G.
        • Greitz T.
        • et al.
        Regional brain metabolism in schizophrenic patients before and during neuroleptic treatment.
        J Cereb Blood Flow Metab. 1985; 5: 181-182
        • Winters W.D.
        The continuum of CNS excitatory and hallucinosis.
        in: Siegel R.K. West L.J. Hallucinations. 1975: 53-70 (New York)
        • Zerssen D.von
        Sartorius N. Ban T.A. Clinical Self-Rating-Scales (CSRS) of the Munich Psychiatric Information System (PSYCHIS Mönchen). Springer, Berlin1986: 270-303
        • Zubin J.
        • Spring B.
        Vulnerability—a new view of schizophrenia.
        J Abnorm Psychol. 1977; 86: 103-126

      Article info

      Publication history

      Received in revised form: June 17, 1992
      Received: February 18, 1992

      Identification

      DOI: https://doi.org/10.1016/0006-3223(92)90059-9

      Copyright

      © 1992 Published by Elsevier Inc.

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