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Research Article| Volume 32, ISSUE 4, P302-311, August 15, 1992

GABA agonist-induced changes in motor, oculomotor, and attention measures correlate in schizophrenics with tardive dyskinesia

  • Shawn L. Cassady
    Correspondence
    Addressed reprint requests to Dr. Shawn L. Cassady, Maryland Psychiatric Research Center, P.O. Box 21247, Baltimore, MD 21228.
    Footnotes
    Affiliations
    From the Maryland Psychiatric Research Center, University of Maryland School of Medicine, P.O. Box 21247, Baltimore, MD 21228, USA
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  • Gunvant K. Thaker
    Footnotes
    Affiliations
    From the Maryland Psychiatric Research Center, University of Maryland School of Medicine, P.O. Box 21247, Baltimore, MD 21228, USA
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  • Marianne Moran
    Footnotes
    Affiliations
    From the Maryland Psychiatric Research Center, University of Maryland School of Medicine, P.O. Box 21247, Baltimore, MD 21228, USA
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  • Adrienne Birt
    Footnotes
    Affiliations
    From the Maryland Psychiatric Research Center, University of Maryland School of Medicine, P.O. Box 21247, Baltimore, MD 21228, USA
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  • Carol A. Tamminga
    Footnotes
    Affiliations
    From the Maryland Psychiatric Research Center, University of Maryland School of Medicine, P.O. Box 21247, Baltimore, MD 21228, USA
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  • Author Footnotes
    ∗ The authors would like to thank John and Richard Ellsberry, Juanita Layne-Gedge, and Coleen Heckner for their technical assistance in conducting this study and Ann Summerfelt and Deb Medoff for their statistical assistance.
DOI:https://doi.org/10.1016/0006-3223(92)90035-X
GABA agonist-induced changes in motor, oculomotor, and attention measures correlate in schizophrenics with tardive dyskinesia
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      Abstract

      Saccadic distractibility, Stroop color-word scores, and serial dyskinesia assessments were obtained on 10 schizophrenic patients with tardive dyskinesia during a pharmacologic challenge with placebo or 7 mg muscimol, a potent, direct-acting GABA agonist. Although no significant difference in the measures was evident between conditions, a significant correlation was found between GABA agonist-induced changes in saccadic distractibility and dyskinesia scores where no correlation existed between these measures on placebo. Improvement in saccadic distractibility was also correlated with reduction in attention performance, as measured by Stroop. These effects are not due to sedation. The correlation between dyskinesia and saccadic distractibility is consistent with a model of parallel motor and oculomotor cortico-striatal-thalamic circuits in humans. This work supports the hypothesis that a dysfunction in GABA-mediated neurotransmission may be the basis for tardive dyskinesia.
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      Article info

      Publication history

      Received in revised form: April 7, 1992
      Received: November 16, 1991

      Footnotes

      ☆An abstract of this work was presented at the International Congress on Schizophrenia Research, Tucson, AZ 1991.

      ☆☆This work was supported in part by National Institute of Mental Health grants MH 43031, MH 37073, MH 18914, and P50-MH 40279.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(92)90035-X

      Copyright

      © 1992 Published by Elsevier Inc.

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