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Abstract
The possibility that a subclinical deficiency of the trace element selenium might
exist in a sample of the British population was examined by giving a selenium supplement
for 5 weeks. Using a double-blind cross-over design, 50 subjects received either a
placebo or 100 mcg selenium on a daily basis. On three occasions they filled in the
Profile of Moods States. A food frequency questionnaire was used to estimate the intake
of selenium in the diet. Intake was associated with a general elevation of mood and
in particular, a decrease in anxiety. The change in mood when taking the active tablet
was correlated with the level of selenium in the diet, which was estimated from a
food frequency questionnaire. The lower the level of selenium in the diet the more
reports of anxiety, depression, and tiredness, decreased following 5 weeks of selenium
therapy. The results are discussed in terms of the low level of selenium in the food
chain in some parts of the world.
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Article Info
Publication History
Received in revised form:
November 6,
1990
Received:
July 24,
1990
Footnotes
☆The support by Larkhall Laboratories, Putney, London is gratefully acknowledged.
Identification
Copyright
© 1991 Published by Elsevier Inc.
