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Research Article| Volume 29, ISSUE 1, P82-88, January 01, 1991

Tobacco smoking increases square-wave jerks during pursuit eye movements

DOI:https://doi.org/10.1016/0006-3223(91)90212-5
Tobacco smoking increases square-wave jerks during pursuit eye movements
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      Abstract

      Smooth-pursuit eye-movement (SPEM) abnormalities have been consistenly observed in schizophrenia. The SPEM changes in schizophrenia are not thought to be an artifact of voluntary attention or medication, although a number of nondisease factors are known to affect SPEM. However, cigarette smoking has recently been reported to deteriorate SPEM in both smokers and nonsmokers. This finding is particularly relevant to schizophrenia, because schizophrenic patients smoke cigarettes considerably more than do normals, and none of the previous studies in this patient group have controlled for smoking. The current study was initiated to examine the effects of smoking on a number of oculomotor measures, including SPEM in smoker and nonsmoker normal volunteers. The results of this study suggest that cigarette smoking induces or significantly increases square-wave jerks, especially during smooth pursuit in normals. However, the effect is small and the global qualitative SPEM score is not affected. Other eye movements such as latencies for reflex and volitional saccades and saccadic distractibility are also unaffected by smoking. No differences were apparent between chronic smokers and nonsmokers under nonsmoking conditions in any of the eye-movement measures.
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      References

        • Abel L.A.
        • Hertle R.W.
        Effects of psychoactive drugs on ocular motor behavior.
        in: Johnston C.W. Plrozzolo F.J. Neurospsychology of Eye Movements. Erlbaum Publishers, Hillsdale NJ1988: 81-114
        • Abel L.A.
        • Zlegler A.S.
        Smooth pursuit eye movements in schizophrenia — What constitutes quantitative assessement?.
        Biol Psychiatry. 1988; 24: 747-761
        • Dell'Osso L.F.
        • Troost B.T.
        • Daroff R.B.
        Macro square wave jerks.
        Neurology. 1975; 25: 975-979
        • Clarke P.B.S.
        • Schwartz R.D.
        • Paul S.M.
        • Pert C.B.
        Nicotinic binding in rat brain: Autoradiographic comparison of (3H) acetyl-choline, (3H)-nicotine, and (125I)-alpha-bungarotoxin.
        J Neurosci. 1985; 5: 1307-1315
        • Elidan J.
        • Gay I.
        • Lev S.
        Square wave-jerks–Incidence, characteristics and significance.
        J Otolaryngol. 1984; 13: 375-381
        • Fleiss J.L.
        The Design and Analyses of Clinical Experiments.
        Wiley, New York1986
        • Flom M.C.
        • Brown B.
        • Adams A.J.
        • Jones R.T.
        Alcohol and marijuana effects on ocular tracking.
        Am J Optom Phys Opt. 1976; 53: 764-773
        • Friedman J.
        • Meares R.
        Tobacco smoking and cortical evoked potentials: An opposite effect on auditory and visual systems.
        Clin Exp Pharmacol Physiol. 1980; 7: 609-615
        • Fuxe K.
        • Anderson K.
        • Eneroth P.
        • Harfstrand A.
        • Agnati L.F.
        Neuroendocrine actions of nicotine and exposure to cigarette smoke: Medical implications.
        Psychoendocrinology. 1989; 14: 19-41
        • Herishanu Y.O.
        • Sharpe J.A.
        Normal square wave jerks.
        Invest Opthalmol Vis Sci. 1981; 20: 268-271
        • Holzman P.H.
        Recent studies of psychophysiology in schizophrenia.
        Schizophr Bull. 1987; 13: 49-75
        • Isaac P.F.
        • Rand M.J.
        Blood levels of nicotine and physiological effects after inhalation of tobacco smoke.
        Eur J Pharmacol. 1969; 8: 269-283
        • Jung R.
        • Kornhuber H.H.
        Results of electro-nystagmography in man. The value of optokinetic, vestibular and spontaneous nystagmus for neurologic diagnosis and research.
        in: Bender M. The Oculomotor System. Harper & Row, New York1964: 440
        • Levin S.
        • Jones A.
        • Stark L.
        • Merrin E.I.
        • Holzman P.S.
        Identification of abnormal patterns in eye movements in schizophrenic patients.
        Arch Gen Psychiatry. 1982; 39: 1125-1130
        • Levin S.
        • Luebke A.
        • Zee D.S.
        • Hain T.C.
        • Robinson D.A.
        • Holzman P.S.
        Smooth pursuit eye movements in schizophrenic: Quantitative measurements with teh search-coil technique.
        J Psychiatr Res. 1988; 22: 195-206
        • Masterson E.
        • O'Shea B.
        Smoking and malignancy in schizophrenia.
        Br J Psychiatry. 1984; 145: 429-432
        • Shagass C.
        • Roemer R.A.
        • Amadeo M.
        Eye tracking performance in psychiatric patients.
        Biol Psychiatry. 1974; 9: 245-260
        • Sharpe J.A.
        • Herishanu Y.O.
        • White O.B.
        Cerebral square wave jerks.
        Neurology. 1982; 32: 57-62
        • Sibony P.A.
        • Evinger C.
        • Manning K.A.
        Tobacco-induced primary-position upbeat nystagmus.
        Ann Neurol. 1987; 21: 53-58
        • Sibony P.A.
        • Evinger C.
        • Manning K.A.
        The effects of tobacco smoking on smooth pursuit eye movements.
        Ann Neurol. 1988; 22: 238-241
        • Spitzer R.L.
        • Endicott J.
        Schedule for Affective Disorders and Schizophrenia-Lifetime Version.
        3rd ed. New York State Psychiatric Institute, Biometrics Research, New York1979
        • Thaker G.K.
        • Nguyen J.A.
        • Tamminga C.A.
        Increased saccadic distractibility in tardive dyskinesia: Functional evidence for subcortical GABA dysfunction.
        Biol Psychiatry. 1989; 25: 49-59
        • Thaker G.K.
        • Kirkpatrick B.
        • Buchanan R.W.
        • Ellsberry R.
        • Lahti A.
        • Tamminga C.A.
        Oculomotor abnormalities and their clinical correlates in schizophrenia.
        Psychopharm Bull. 1989; 25: 491-497

      Article info

      Publication history

      Received in revised form: July 2, 1990
      Received: November 25, 1989

      Identification

      DOI: https://doi.org/10.1016/0006-3223(91)90212-5

      Copyright

      © 1991 Published by Elsevier Inc.

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