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Research Article| Volume 30, ISSUE 11, P1075-1092, December 01, 1991

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Memory effects of clomipramine treatment: Relationship to CSF monoamine metabolites and drug concentrations in plasma

DOI:https://doi.org/10.1016/0006-3223(91)90179-P
Memory effects of clomipramine treatment: Relationship to CSF monoamine metabolites and drug concentrations in plasma
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      Abstract

      Performance on tasks tapping automatic and voluntary aspects of memory, attention, and motor speed was examined in 14 patients with major depressive disorder, before and after 3 weeks of treatment with clomipramine (150 mg/day), a potent serotonin and noradrenaline uptake blocker with anticholinergic side effects. Performance on tasks requiring frontal functions improved or did not change, whereas verbal learning and retention, where hippocampal functioning is critical, were impaired. The latter tasks were negatively related to cerebrospinal fluid (CSF) 5-HIAA levels and plasma concentration of clomipramine. The results provide further support for the regulatory role of monoaminergic systems in cognition. Furthermore, we found the automatic-voluntary capacity distinction less heuristically useful. Physiological mechanisms regulating different aspects of cognition and memory appeared to be more closely related to the type of task used than to its capacity-demanding properties.
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      Article info

      Publication history

      Received in revised form: June 11, 1991
      Received: April 10, 1990

      Footnotes

      ☆This study was supported by funds from the Swedish Medical Research Council (5454, 4545), the Söderström-König Foundation, Torsten and Ragnar Söderberg Foundation, Fredrik and Ingrid Thuring Foundation, and funds from the Karolinska Institute. The cooperation of Alexandra Tylec and Pia Elmlund with the analyses of biochemical samples and the assistance of Mats Samuelsson are gratefully acknowledged.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(91)90179-P

      Copyright

      © 1991 Published by Elsevier Inc.

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