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Research Article| Volume 30, ISSUE 2, P131-139, July 15, 1991

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Serotonin uptake and imipramine binding in the blood platelets of obsessive-compulsive disorder patients

  • Bijan Bastani
    Correspondence
    Address reprint requests to Bijan Bastani, M.D., Psychobiology Clinic, University Hospitals of Cleveland, 2040 Abington Road, Cleveland, OH 44106-5000.
    Footnotes
    Affiliations
    Department of Psychiatry, Laboratory of Biological Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
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  • Ramesh C. Arora
    Affiliations
    Department of Psychiatry, Laboratory of Biological Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
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  • Herbert Y. Meltzer
    Footnotes
    Affiliations
    Department of Psychiatry, Laboratory of Biological Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
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  • Author Footnotes
    2 We are grateful to Ms. Lisa Kregel for laboratory assistance, Mr. William Daley for coordinating research activities, Ms.Jar-chi Lee for data analysis, and to Ms. Lee Mason for typing the manuscript.
    1 Herbert Y. Meltzer is the recipient of a USPHS Research Career Scientist Award MH 47808.
DOI:https://doi.org/10.1016/0006-3223(91)90166-J
Serotonin uptake and imipramine binding in the blood platelets of obsessive-compulsive disorder patients
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      Abstract

      14C-Serotonin (5-HT) uptake and 3H-imipramine binding (IB) were studied in the blood platelets of 20 obsessive-compulsive disorder (OCD) patients, 53 normal controls (5-HT uptake) and 32 normal controls (IB binding). The maximum number of binding sites (Bmax) was significantly decreased in OCD patients compared to normal controls, but there was no difference in the affinity for 3H-imipramine (Kd). The affinity for 5-HT uptake (Km) was also decreased in the OCD patients but the maximum velocity of 5-HT uptake sites (Vmax) was not significantly different in OCD patients and normal volunteers. There were trends for the Slowness Subscale of the Maudsley Obsessional-Compulsive Inventory (MOCI) to be positively correlated with the Km of 5-HT uptake (p = 0.094), whereas the Global Scale, Checking Subscale, and Doubting Conscientiousness Subscale of MOCI were negatively correlated with the Kd of IB (p = 0.066, p = 0.08, and p = 0.062, respectively). The results provide further evidence for the dysfunction of the serotonergic system in OCD.
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      Article info

      Publication history

      Received in revised form: January 23, 1991
      Received: May 24, 1990

      Footnotes

      ☆The research reported was supported in part by USPHS MH 41684, MH 41594, MO1RR00080 and grants from the Cleveland and Sawyer Foundations.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(91)90166-J

      Copyright

      © 1991 Published by Elsevier Inc.

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