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Research Article| Volume 30, ISSUE 12, P1205-1218, December 15, 1991

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Mood state in unilateral temporal lobe epilepsy

  • Bruce P. Hermann
    Correspondence
    Address reprint requests to: Bruce Hermann, Ph.D., EpiCare Center, 910 Madison Avenue, Suite 906, Memphis, TN 38103.
    Affiliations
    From EpiCare Center, Baptist Memorial Hospital, Memphis, TN, USA

    Departments of Psychiatry and Neurosurgery, University of Tennessee, Memphis, TN, USA

    Department of Psychology, University of Health Sciences, Chicago Medical School, North Chicago, IL, USA

    Semmes-Murphey Clinic, Memphis, TN, USA
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  • Michael Seidenberg
    Affiliations
    From EpiCare Center, Baptist Memorial Hospital, Memphis, TN, USA

    Departments of Psychiatry and Neurosurgery, University of Tennessee, Memphis, TN, USA

    Department of Psychology, University of Health Sciences, Chicago Medical School, North Chicago, IL, USA

    Semmes-Murphey Clinic, Memphis, TN, USA
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  • Alan Haltinerr
    Affiliations
    From EpiCare Center, Baptist Memorial Hospital, Memphis, TN, USA

    Departments of Psychiatry and Neurosurgery, University of Tennessee, Memphis, TN, USA

    Department of Psychology, University of Health Sciences, Chicago Medical School, North Chicago, IL, USA

    Semmes-Murphey Clinic, Memphis, TN, USA
    Search for articles by this author
  • Allen R. Wyler
    Affiliations
    From EpiCare Center, Baptist Memorial Hospital, Memphis, TN, USA

    Departments of Psychiatry and Neurosurgery, University of Tennessee, Memphis, TN, USA

    Department of Psychology, University of Health Sciences, Chicago Medical School, North Chicago, IL, USA

    Semmes-Murphey Clinic, Memphis, TN, USA
    Search for articles by this author
DOI:https://doi.org/10.1016/0006-3223(91)90157-H
Mood state in unilateral temporal lobe epilepsy
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      Abstract

      The purpose of this investigation was to reexamine the relationship between self-reported depression and laterality of temporal lobe epilepsy and to determine the contribution of associated frontal lobe dysfunction in predisposing patients to depression. Sixty-four patients with complex partial seizures of left (n = 26) or right (n = 38) temporal lobe origin were administered several self-report measures of mood state (Beck Depression Inventory, Center for Epidemiological Studies-Depression scale, Beck Anxiety Inventory), and a test of frontal lobe function [Wisconsin Card Sorting Test (WCST)]. There were no overall differences between the left and right temporal lobe groups on the measures of depression and anxiety. However, the left temporal lobe group exhibited a significant relationship between the degree of associated frontal lobe dysfunction (as indicated by increased perseverative responding on the WCST) and dysphoric mood state. For the right temporal lobe group there was a nonsignificant inverse relationship between mood state and indices of frontal lobe dysfunction. These results (1) are consistent with the broader psychiatric literature, which has implicated a relationship between depression and left frontal lobe dysfunction, (2) suggest that previous conflicting reports of depression/left temporal lobe epilepsy relationship are due in part to variations in the intactness of frontal lobe function, and (3) suggest that the presence of associated frontal lobe dysfunction may be a consideration in understanding interictal psychopathology in epilepsy.
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      References

        • Abou-Khalil B.W.
        • Siegel G.J.
        • Sackellares J.C.
        • et al.
        Position emission tomography studies of cerebral glucose metabolism in chronic partial epilepsy.
        Ann Neurol. 1987; 22: 480-486
        • Altshuler L.L.
        • Devinsky O.
        • Post R.M.
        • Theodore W.
        Depression, anxiety, and temporal lobe epilepsy: Laterality of focus and symptoms.
        Arch Neurol. 1990; 47: 284-288
        • Anderson S.W.
        • Tranel D.
        Awareness of disease states following cerebral infarction, dementia, and head trauma.
        Clin Neuropsychol. 1989; 3: 327-339
        • Barclough B.M.
        The suicide rate of epilepsy.
        Acta Psychiatr Scand. 1987; 76: 339-345
        • Baxter L.
        • Schwartz J.M.
        • Phelps M.
        • et al.
        Reduction of prefrontal cortex glucose metabolism common to three types of depression.
        Arch Gen Psychiatry. 1989; 46: 243-250
        • Beck A.T.
        • Ward C.H.
        • Mendelson M.
        • Mock J.
        • Erbaugh J.
        An inventory for measuring depression.
        Arch Gen Psychiatry. 1961; 4: 561-568
        • Beck A.T.
        • Steer R.A.
        • Gurbin M.G.
        Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation.
        Clin Psychol Rev. 1988; 8: 77-100
        • Beck A.T.
        • Epstein N.
        • Brown G.
        • Steer R.A.
        An inventory for measuring clinical anxiety.
        J Consult Clin Psychol. 1988; 56: 893-897
        • Betts T.A.
        Depression, anxiety and epilepsy.
        in: Reynolds E.H. Trimble M.R. Epilepsy and Psychiatry. Churchill Livingstone, New York1981: 60-71
        • Blume W.T.
        • Grabow J.D.
        • Darley F.L.
        • et al.
        Intracarotid amobarbital test of language and memory before temporal lobectomy for seizure control.
        Neurology. 1973; 23: 812-819
        • Currie S.
        • Heathfield K.W.G.
        • Henson R.A.
        • Scott D.F.
        Clinical course and prognosis of temporal lobe epilepsy: A survey of 666 cases.
        Brain. 1971; 94: 173-190
        • Damasio A.R.
        The frontal lobes.
        in: Heilman K.M. Valenstein E. Clinical Neuropsychology. Oxford University Press, New York1985: 339-375
        • Dominian J.
        • Serafetinides E.A.
        • Dewhurst M.
        A follow-up study of late onset epilepsy.
        Br Med J. 1963; 1: 431-435
        • Drewe E.A.
        The effect of type and area of brain lesion on Wisconsin Card Sorting Test performance.
        Cortex. 1974; 10: 159-170
        • Edeh J.
        • Toone B.K.
        • Corney R.H.
        Epilepsy, psychiatric morbidity, and social dysfunction in general practice.
        Neuropsychiatry Neuropsychol Behav Neurol. 1990; 3: 180-192
        • Engel Jr, J.
        The Hans Berger lecture: Functional explorations of the human brain and their therapeutic implications.
        Electroencephalogr Clin Neurophysiol. 1990; 76: 296-316
        • Engel Jr, J.
        • Kuhl D.E.
        • Phelps M.
        • Rausch R.
        • Nuwer M.
        Local cerebral metabolism during partial seizures.
        Neurology. 1983; 33: 400-413
        • Ensel W.M.
        Measuring depression: The CES-D scale.
        in: Lin N. Dean A. Ensel W. Social Support, Life Events, and Depression. Academic, New York1986: 51-70
        • Hannay H.J.
        • Falgout J.C.
        • Leli D.A.
        • Katholi C.R.
        • Halsey J.H.
        • Willis E.L.
        Focal right temporo-occipital blood flow changes associated with judgement of line orientation.
        Neuropsychologia. 1987; 25: 755-763
        • Hauser W.A.
        • Hesdorffer D.C.
        Epilepsy: Frequency, Causes and Consequences.
        Demos Publications, New York1990
        • Hawton K.
        • Fagg J.
        • Marsack P.
        Association between epilepsy and attempted suicide.
        J Neurol Neurosurg Psychiatry. 1980; 43: 168-170
        • Heaton R.K.
        Wisconsin Card Sorting Test.
        Psychological Assessment Resources, Odessa, FL1981
        • Heller W.
        The neuropsychology of emotion: developmental patterns and implications for psychopathology.
        in: Stein W.L. Leventhal B. Trabasso T. Psychological and Biological Approaches to Emotion. Lawrence Erlbaum Associates, Hillsdale, NJ1990
        • Hermann B.P.
        • Whitman S.
        Behavioral and personality correlates of epilepsy: A review, methodological critique, and conceptual model.
        Psychol Bull. 1984; 95: 451-497
        • Hermann B.P.
        • Whitman S.
        Psychosocial predictors of interictal depression.
        J Epilepsy. 1989; 2: 231-237
        • Hermann B.P.
        • Wyler A.R.
        • Richey E.T.
        Epilepsy, frontal lobe, and personality.
        Biol Psychiatry. 1987; 22: 1055-1057
        • Hermann B.P.
        • Wyler A.R.
        • Richey E.T.
        Wisconsin Card Sorting Test performance in patients with complex partial seizures of temporal-lobe origin.
        J Clin Exp Neuropsychol. 1988; 10: 467-476
        • Hertzog C.
        • Van Alstine J.
        • Usala P.D.
        • Hultsch D.F.
        • Dixon R.
        Measurement properties of the Center for Epidemiological Studies Depression Scale (CES-D) in older populations.
        Psychol Assess. 1990; 2: 64-72
        • House A.
        • Dennis M.
        • Molyneux A.
        • Warlow C.
        • Hawton K.
        Emotionalism after stroke.
        Br Med J. 1989; 298: 991-994
        • House A.
        • Dennis M.
        • Warlow C.
        • Hawton K.
        • Molyneux A.
        Mood disorders after stroke and their relation to lesion location: A CT scan study.
        Brain. 1990; : 1113-1129
        • Kendrick J.F.
        • Gibbs F.A.
        Interrelations of mesial temporal and orbital frontal areas of man revealed by strychnine spikes.
        Arch Neurol Psychiatry. 1958; 79: 518-524
        • Kogeorgos J.
        • Fonagy P.
        • Scott D.F.
        Psychiatric sympton profiles of chronic epileptics attending a neurologic clinic: A controlled investigation.
        Br J Psychiatry. 1982; 140: 236-243
        • Lieb J.P.
        • Dashieff R.M.
        • Engel Jr, J.
        Role of frontal lobes in propagation of ictal discharges originating in mesiotemporal regions.
        Epilepsia. 1989; 30: 664
        • Martinot J.
        • Hardy P.
        • Feline A.
        • et al.
        Left prefrontal glucose hypometabolism in the depressed state: A confirmation.
        Am J Psychiatry. 1990; 147: 1313-1317
        • Matthews W.S.
        • Barabas G.
        Suicide and epilepsy: A review of the literature.
        Psychosomatics. 1981; 22: 515-524
        • Mayberg H.S.
        • Starkstein S.E.
        • Sadzot B.
        • et al.
        Selective hypometabolism in the inferior frontal lobe in depressed patients with Parkinson's disease.
        Ann Neurol. 1990; 28: 57-64
        • McGlynn S.M.
        • Schachter D.L.
        Unawareness of deficits in neuropsychological syndromes.
        J Clin Exp Neuropsychol. 1989; 11: 143-205
        • Mendez M.F.
        • Cummings J.L.
        • Benson D.F.
        Depression in epilepsy. Significance and phenomenology.
        Arch Neurol. 1986; 43: 766-770
        • Milner B.
        Effects of different brain lesions on card sorting.
        Arch Neurol. 1963; 9: 90-100
        • Perini G.
        • Mendius R.
        Depression and anxiety in complex partial seizures.
        J Nerv Ment Dis. 1984; 172: 287-290
        • Radloff L.S.
        The CES-D scale: A self-report depression scale for research in the general population.
        Appl Psychol Measure. 1977; 1: 385-401
        • Radloff L.S.
        • Locke B.Z.
        The community mental health assessment survey and the CES-D scale.
        in: Weissman M.M. Meyers J. Ross C.E. Epidemiologic Community Surveys. Prodist, New York1983
        • Robertson M.M.
        The organic contribution to depressive illness in patients with epilepsy.
        J Epilepsy. 1989; 2: 189-230
        • Robertson M.M.
        Ictal and interictal depression in patients with epilepsy.
        in: Trimble M.R. Bolwig T.G. Aspects of Epilepsy and Psychiatry. Wiley, New York1990: 213-233
        • Robertson M.M.
        • Trimble M.R.
        • Townsend H.R.A.
        Phenomenology of depression in epilepsy.
        Epilepsia. 1987; 28: 364-368
        • Robinson R.G.
        • Szetela B.
        Mood changes following left hemispheric brain injury.
        Ann Neurol. 1981; 9: 447-453
        • Robinson A.L.
        • Heaton R.K.
        • Lehman R.A.W.
        • Stilson D.W.
        The utility of the Wisconsin Card Sorting Test in detecting and localizing frontal lobe lesions.
        J Consult Clin Psychol. 1980; 48: 605-614
        • Robinson R.G.
        • Starr L.
        • Kubos K.L.
        • Price T.R.
        A two-year longitudinal study of poststroke mood disorders: Findings during the initial evaluation.
        Stroke. 1983; 14: 736-741
        • Robinson R.G.
        • Kubos K.L.
        • Starr L.
        • Rao K.
        • Price T.R.
        Mood disorders in stroke patients: Importance of lesion location.
        Brain. 1984; 107: 81-93
        • Robinson R.G.
        • Starr L.
        • Lipsey J.R.
        • Rao K.
        • Price T.R.
        A two-year longitudinal study of poststroke mood disorders: Dynamic changes in associated variables over the first six months of follow-up.
        Stroke. 1984; 15: 510-517
        • Robinson R.G.
        • Bolduc P.L.
        • Price T.R.
        Two-year longitudinal study of poststroke mood disorders: Diagnosis and outcome at one and two years.
        Stroke. 1987; 18: 837-843
        • Roy A.
        Some determinants of affective symptoms in epileptics.
        Can J Psychiatry. 1979; 24: 554-556
        • Starkstein S.E.
        • Robinson R.G.
        • Price T.R.
        Comparison of cortical and subcortical lesions in the production of poststroke mode disorders.
        Brain. 1987; 110: 1045-1059
        • Stevens J.R.
        Interictal clinical manifestations of complex partial seizures.
        in: Penry J.K. Daly D.D. Advances in Neurology. Raven, New York1975
        • Stevens J.R.
        • Hermann B.P.
        Temporal lobe epilepsy, psychopathology, and violence: The state of the evidence.
        Neurology. 1981; 31: 1127-1132
        • Stuss D.T.
        • Benson D.F.
        The Frontal Lobes.
        Raven, New York1986
        • Theodore W.H.
        • Newmark M.E.
        • Sato S.
        • et al.
        Fluorodeoxyglucose position emission tomography in refractory complex partial seizures.
        Ann Neurol. 1983; 14: 429-437
        • Tomarken A.J.
        • Davidson R.J.
        • Henriques J.B.
        Resting frontal brain asymmetry predicts affective responses to films.
        J Pers Soc Psychol. 1990; 59: 791-801
        • Trimble M.R.
        • Perez M.M.
        Quantification of psychopathology in adult patients with epilepsy.
        in: Kulig B.M. Meinardi H. Stores G. Epilepsy and Behavior '79. Swets and Zeitlinger, Lisse1980: 118-126
        • Trostle J.A.
        • Hauser W.A.
        • Sharbrough F.W.
        Psychological and social adjustment to epilepsy in Rochester.
        Neurology. 1989; 39 (Minnesota): 633-637
        • Wechsler D.
        Wechsler Adult Intelligence Test—Revised Manual. The Psychological Corporation, San Antonio, TX1981
        • Weinberger D.R.
        • Berman K.
        • Zec R.F.
        Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia.
        Arch Gen Psychiatry. 1986; 43: 114-124
        • Weissman M.M.
        • Sholomskas D.
        • Pottenger M.
        • Prusoff B.A.
        • Locke B.Z.
        Assessing depressive symptoms in five psychiatric populations: A validation study.
        Am J Epidemiol. 1977; 106: 203-214
        • Wyler A.R.
        • Ojemann G.
        • Lettich E.
        • Ward Jr, A.A.
        Subdural strip electrodes for localizing epileptogenic foci.
        J Neurosurg. 1984; 60: 1195-1200
        • Zielinski J.J.
        Epilepsy and mortality rate and cause of death.
        Epilepsia. 1974; 15: 191-201
        • Zielinski J.J.
        Selected psychiatric and psychosocial aspects of epilepsy as seen by an epidemiologist.
        in: Whitman S. Hermann B.P. Psychopathology in Epilepsy: Social Dimensions. Oxford University Press, New York1986: 38-65

      Article info

      Publication history

      Received in revised form: June 27, 1991
      Received: January 24, 1991

      Identification

      DOI: https://doi.org/10.1016/0006-3223(91)90157-H

      Copyright

      © 1991 Published by Elsevier Inc.

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