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Abstract
The purpose of this investigation was to reexamine the relationship between self-reported
depression and laterality of temporal lobe epilepsy and to determine the contribution
of associated frontal lobe dysfunction in predisposing patients to depression. Sixty-four
patients with complex partial seizures of left (n = 26) or right (n = 38) temporal lobe origin were administered several self-report measures of mood
state (Beck Depression Inventory, Center for Epidemiological Studies-Depression scale,
Beck Anxiety Inventory), and a test of frontal lobe function [Wisconsin Card Sorting
Test (WCST)]. There were no overall differences between the left and right temporal
lobe groups on the measures of depression and anxiety. However, the left temporal
lobe group exhibited a significant relationship between the degree of associated frontal
lobe dysfunction (as indicated by increased perseverative responding on the WCST)
and dysphoric mood state. For the right temporal lobe group there was a nonsignificant
inverse relationship between mood state and indices of frontal lobe dysfunction. These
results (1) are consistent with the broader psychiatric literature, which has implicated
a relationship between depression and left frontal lobe dysfunction, (2) suggest that
previous conflicting reports of depression/left temporal lobe epilepsy relationship
are due in part to variations in the intactness of frontal lobe function, and (3)
suggest that the presence of associated frontal lobe dysfunction may be a consideration
in understanding interictal psychopathology in epilepsy.
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Article info
Publication history
Received in revised form:
June 27,
1991
Received:
January 24,
1991
Identification
Copyright
© 1991 Published by Elsevier Inc.