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Abstract
Narcolepsy is the disease disclosing the strongest association with the HLA system.
Almost 100% of cases are associated with HLA-DR2 antigen. Moreover, narcolepsy is
often characterized by the occurrence of sleep-onset REM (SOREM) periods. SOREM has
also been demonstrated in major depression. To further investigate the relationship
between SOREM and HLA-DR2, HLA-DR and HLA-DQ antigens were assessed in 50 research
diagnostic criteria (RDC) major depressed patients. Depressed patients were elected
for HLA typing on the basis of the presence of at least one SOREM period (n = 29)
or three REM latencies above 50 min (n = 21) during three consecutives EEG nights
recording. No significant differences were observed in the frequency of HLA-DR or
HLA-DQ antigens between patients and controls. These results demonstrate a lack of
association between SOREM and HLA-DR2 in major depression, and also do not confirm
the presence of an association between antigens encoded by the HLA region of the chromosome
6 and major depressive illness.
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Article info
Publication history
Received in revised form:
June 24,
1991
Received:
February 13,
1991
Identification
Copyright
© 1991 Published by Elsevier Inc.
