Research Article| Volume 29, ISSUE 7, P647-657, April 01, 1991

Dose-response effects of oral yohimbine in unrestrained primates

  • Leonard A. Rosenblum
    Address reprint requests to Dr. Leonard A. Rosenblum, Box 120, SUNY Health Science Center, 450 Clarkson Avenue, Brooklyn, NY 11203.
    From the Department of Psychiatry and the Primate Behavior Laboratory, SUNY/Health Science Center at Brooklyn, USA
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  • Jeremy D. Coplan
    From the Department of Psychiatry and the Primate Behavior Laboratory, SUNY/Health Science Center at Brooklyn, USA

    the Department of Psychiatry, Columbia University, College of Physicians and Surgeons, USA
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  • Steven Friedman
    From the Department of Psychiatry and the Primate Behavior Laboratory, SUNY/Health Science Center at Brooklyn, USA
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  • Trina Bassoff
    From the Department of Psychiatry and the Primate Behavior Laboratory, SUNY/Health Science Center at Brooklyn, USA
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  • Author Footnotes
    ∗ The authors wish to thank Dr. Gayle Sunderland for her various contributions to this research and Dr. Jack Gorman for his thoughtful consultations.
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      Six unrestrained bonnet macaques were each observed after oral administration of four dosages of yohimbine hydrochloride (0.10, 0.25, 0.50, and 0.75 mg/kg) and a placebo. Yohimbine significantly increased episodes of motoric activation and affective response interspersed with intervals of behavioral enervation. Yohimbine scores correlated closely with baseline levels; there was no dose-response relationship. Response to oral yohimbine differed in several ways from subcutaneous and intravenous sodium lactate infusions, including prominent enervative symptoms and the appearance of sexual arousal. In light of the appearance of cyclic enervative episodes, this study suggests limitations to primate models of panic disorder utilizing oral yohimbine.
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