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Research Article| Volume 29, ISSUE 7, P629-634, April 01, 1991

High central D2-dopamine receptor occupancy as assessed with positron emission tomography in medicated but therapy-resistant schizophrenic patients

  • Hubert J. Coppens
    Footnotes
    Affiliations
    From the Department of Clinical Psychiatry, of the Groningen University, and the Psychiatric Hospital “Licht en Kracht”, Assen (Slooff, the Netherlands
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  • Cees J. Slooff
    Footnotes
    Affiliations
    From the Department of Clinical Psychiatry, of the Groningen University, and the Psychiatric Hospital “Licht en Kracht”, Assen (Slooff, the Netherlands
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  • Anne M.J. Paans
    Footnotes
    Affiliations
    Department of Nuclear Medicine, of the Groningen University, and the Psychiatric Hospital “Licht en Kracht”, Assen (Slooff, the Netherlands
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  • Tonnie Wiegman
    Footnotes
    Affiliations
    Department of Nuclear Medicine, of the Groningen University, and the Psychiatric Hospital “Licht en Kracht”, Assen (Slooff, the Netherlands
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  • Willem Vaalburg
    Footnotes
    Affiliations
    Department of Nuclear Medicine, of the Groningen University, and the Psychiatric Hospital “Licht en Kracht”, Assen (Slooff, the Netherlands
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  • Jakob Korf
    Correspondence
    Address reprint requests to J. Korf, Department of Biological Psychiatry, Psychiatric University Clinic, Oostersingel 59, NL 9713 EZ Groningen, the Netherlands.
    Footnotes
    Affiliations
    Department of Biological Psychiatry, of the Groningen University, and the Psychiatric Hospital “Licht en Kracht”, Assen (Slooff, the Netherlands
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  • Author Footnotes
    ∗ The help of Drs. J.W. Louwerens and D. Tulner is greatly appreaciated.
DOI:https://doi.org/10.1016/0006-3223(91)90132-6
High central D2-dopamine receptor occupancy as assessed with positron emission tomography in medicated but therapy-resistant schizophrenic patients
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      Abstract

      We investigated whether the lack of therapeutic response to long-term and adequate neuroleptic treatment was due to a failure to achieve a blockade of cerebral dopamine receptors. Six chronic schizophrenic and medicated patients (DSM-III-R diagnosis, paranoid or disorganized type) were assessed with the Present State Examination and the Brief Psychiatric Rating Scale. According to the Chouinard Rating Scale there were little extrapyramidal symptoms, although no anticholinergic drugs were given. Plasma levels of the neuroleptics were determined and found in the therapeutic range or higher. Dopamine D2-receptor occupancy was determined with positron emission tomography using 11C-methylspiperone as ligand. There was a more than 95% blockade of the D2 receptors in the striatum. These results indicate that the lack of therapeutic response and extrapyramidal side effects cannot be attributed to an incomplete blockade of cerebral D2 receptors and that the pathogenetic role of these receptors can be questioned in therapy-resistant schizophrenic patients.
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      Article info

      Publication history

      Received in revised form: October 3, 1990
      Received: July 2, 1989

      Footnotes

      ☆This study was supported in part by Squibb BV (the Netherlands).

      Identification

      DOI: https://doi.org/10.1016/0006-3223(91)90132-6

      Copyright

      © 1991 Published by Elsevier Inc.

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