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Brief report| Volume 30, ISSUE 3, P310-312, August 01, 1991

Serotonin-stimulated Ca2+ response is increased in the blood platelets of depressed patients

  • Ichiro Kusumi
    Correspondence
    Address reprint requests to Dr. Ichiro Kusumi, Department of Psychiatry and Neurology, Hokkaido University School of Medicine, North 15, West 7, Sapporo, 060, Japan.
    Affiliations
    From the Department of Psychiatry and Neurology, Hokkaido University School of Medicine, Sapporo, 060, Japan
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  • Tsukasa Koyama
    Affiliations
    From the Department of Psychiatry and Neurology, Hokkaido University School of Medicine, Sapporo, 060, Japan
    Search for articles by this author
  • Itaru Yamashita
    Affiliations
    From the Department of Psychiatry and Neurology, Hokkaido University School of Medicine, Sapporo, 060, Japan
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DOI:https://doi.org/10.1016/0006-3223(91)90114-2
Serotonin-stimulated Ca2+ response is increased in the blood platelets of depressed patients
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      References

        • Affolter H.
        • Erne P.
        • Burgisser E.
        • Pletscher A.
        Ca2+ as messenger of 5HT2-receptor stimulation in human blood platelets.
        Naunyn Schmiedebergs Arch Pharmacol. 1984; 325: 337-342
        • Aprison M.H.
        • Takahashi R.
        • Tachiki K.
        Hypersensitive serotonergic receptors involved in clinical depression—A theory.
        in: Haber B. Aprison M.H. Neuropharmacology and Behavior. Plenum, New York1978: 23-53
        • Arora R.C.
        • Meltzer H.Y.
        Increased serotonin2(5-HT2) receptor binding as measured by 3H-lysergic acid diethylamide(3H-LSD) in the blood platelets of depressed patients.
        Life Sci. 1989; 44: 725-734
        • Biegon A.
        • Weizman A.
        • Karp L.
        • Ram A.
        • Tiano S.
        • Wolff M.
        Serotonin 5-HT2 receptor binding on blood platelets—A peripheral marker for depression?.
        Life Sci. 1987; 41: 2485-2492
        • De Courcelles D.D.C.
        • Leysen J.E.
        • De Clerck F.
        • Van Belle H.
        • Janssen P.A.J.
        Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites.
        J Biol Chem. 1985; 260: 7603-7608
        • Geaney D.P.
        • Schächter M.
        • Elliot J.M.
        • Grahame-Smith D.G.
        Characterization of (3H)lysergic acid diethylamide binding to a 5-hydroxytryptamine receptor on human platelet membranes.
        Eur J Pharmacol. 1984; 97: 87-93
        • Grynkiewicz G.
        • Poenie M.
        • Tsien R.Y.
        A new generation of Ca2+ indicators with greatly improved fluorescence properties.
        J Biol Chem. 1985; 260: 3440-3450
        • Kagaya A.
        • Mikuni M.
        • Kusumi I.
        • Yamamoto H.
        • Takahashi K.
        Serotonin-induced acute desensitization of serotonin2 receptors in human platelets via a mechanism involving protein kinase C.
        J Pharmacol Exp Ther. 1990; 255: 305-311
        • Mikuni M.
        • Kusumi I.
        • Kagaya A.
        • Kuroda Y.
        • Mori H.
        • Takahashi K.
        Increased 5-HT-2 receptor function as measured by serotonin-stimulated phosphoinositide hydrolysis in platelets of depressed patients.
        Prog Neuropsychopharmacol Biol Psychiatry. 1991; 15: 49-61
        • Stahl S.M.
        The human platelet: A diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders.
        Arch Gen Psychiatry. 1977; 34: 509-516

      Article info

      Publication history

      Received in revised form: February 15, 1991
      Received: December 11, 1990

      Identification

      DOI: https://doi.org/10.1016/0006-3223(91)90114-2

      Copyright

      © 1991 Published by Elsevier Inc.

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