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Research Article| Volume 30, ISSUE 3, P257-268, August 01, 1991

Phototherapy in nonseasonal depression

DOI:https://doi.org/10.1016/0006-3223(91)90110-8
Phototherapy in nonseasonal depression
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      Abstract

      Previous reports have shown that bright light exposure may benefit patients with seasonal depression. In the present study, the possible therapeutic effect of bright light in non-seasonal major depressive disorder was examined. Forty-two depressed patients not receiving additional antidepressant medication were exposed to bright white light of 2500 lux or dim red light of 50 lux over one week for two hr daily in the morning. The change in depressive symptoms was assessed by rating scales (Hamilton Depression Rating Scale, CGI) and by self-rating scales (Depression Scale, Complaint List, Visual Analgue Scale). Consistent for all ratings, the decrease in depressive symptoms after bright white light was only slight and not different from dim red-light exposure. Contrary to the findings in seasonal affective disorder, phototheraphy administered over one week for two hr daily is not effective in nonseasonal major depressive disorder.
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      References

        • Aitken R.C.B.
        Measuring of feelings using visual analogue scales.
        in: Proc R Soc Med. 62. 1969: 989-993
        • Dietzel M.
        • Saletu B.
        • Lesch O.M.
        • Sieghardt W.
        • Schjerve M.
        Light treatment in depressive illness.
        Eur Neurol. 1986; 25 (Suppl): 93-103
        • Garvey M.J.
        • Tuason V.B.
        • Johnson R.A.
        • Valentine R.H.
        • Cooper T.B.
        Elevated plasma tricyclic levels with therapeutic doses of imipramine.
        Am J Psychiatry. 1984; 141: 853-856
        • Hamilton M.
        Development of a rating scale for primary depressive illness.
        Br J Cos Clin Psychol. 1967; 6: 278-296
        • Hellekson C.J.
        • Kline J.A.
        • Rosenthal N.E.
        Phototheraphy for seasonal affective disorder in Alaska.
        Am J Psychiatry. 1986; 143: 1035-1037
        • Isaacs G.
        • Stainer D.S.
        • Sensky T.E.
        • Moor S.
        • Tomson C.
        Phototherapy and its mechanisms of action in seasonal affective disorder.
        J Affective Disord. 1988; 14: 13-19
        • James S.P.
        • Wehr T.A.
        • Sack D.A.
        • Parry B.L.
        • Rosenthal N.E.
        Treatment of seasonal affective disorder with light in the evening.
        Br J Psychiatry. 1985; 147: 424-428
        • Klein D.F.
        • Gittelman R.
        • Quitkin F.
        • Rifkin A.
        Diagnostic and Drug Treatment of Psychiatric Disorders: Adults and Children.
        2nd ed. William and Wilkens, Baltimore1980
        • Kripke D.F.
        • Mullaney D.J.
        • Atkinson M.
        • Wolf S.
        Circadian rhythm disorders in manic-depressive.
        Biol Psychiatry. 1978; 13: 335-351
        • Kripke D.F.
        • Risch S.C.
        • Janowsky D.
        Bright white light alleviates depression.
        Psychiatry Res. 1983; 10: 105-112
        • Kripke D.F.
        • Risch S.C.
        • Janowsky D.
        Lighting up depression.
        Psychophamacol Bull. 1983; 19: 525-530
        • Kripke D.F.
        • Gillin J.C.
        • Mullaney D.J.
        • Risch S.C.
        • Janowsky D.S.
        Treatment of major depressive disorders by bright white light for 5 days.
        in: Halaris A. Chronobiology and Psychiatric Disorders. Elsevier, Amsterdam1987: 207-218
        • Kripke D.F.
        • Mulllaney D.J.
        • Savides T.J.
        • Gillin J.C.
        Phototeraphy for non-seasonal major depressive disorder.
        in: Rosethal N.E. Blehar M. Seasonal Affective Disorder and Phototherapy. Raven Press, New York1989: 342-356
        • Lehrl S.
        Mehrfachwahl-Wortschatz-Test (MWT-B).
        Erlangen, Straube1978
        • Lewy A.J.
        • Wehr T.A.
        • Goodwin F.K.
        • Newsome D.A.
        • Markey S.P.
        Light suppresses melatonin secretion in humans.
        Science. 1980; 210: 1267-1269
        • Lewy A.J.
        • Wehr T.A.
        • Goodwin F.K.
        • Newsome D.A.
        • Rosenthal N.E.
        Manic-depressive patients may be supersensitive to light.
        Lancet. 1981; 1: 383-384
        • Lewy A.J.
        • Kern H.A.
        • Rosenthal N.E.
        • Wehr T.A.
        Bright artificial light treatment of a manic-depressive patient with a seasonal mood cycle.
        Am J Psychiatry. 1982; 139: 1496-1498
        • Lewy A.J.
        • Sack R.L.
        • Singer C.L.
        Assessment and treatment of chronobiologic disorders using plasma melatonin levels and bright light exposure: The clock-gate model and the phase response curve.
        Psychopharmacol Bull. 1984; 20: 561-565
        • Lewy A.J.
        • Nurnberger J.I.
        • Wehr T.A.
        • et al.
        Supersensitivity to light: Possible trait marker for manic-depressive illness.
        Am J Psychiatry. 1985; 142: 725-727
        • Lewy A.J.
        • Sack R.L.
        • Mille S.
        • Hoban T.M.
        Antidepressant and circadian phase-shifting effects of light.
        Science. 1987; 235: 352-354
        • Lewy A.J.
        • Sack R.L.
        • Singer C.M.
        • White D.M.
        The phase shift hypothesis for bright light's therapeutic mechanism of action: Theoretical considerations and experimental evidence.
        Psychopharmacol Bull. 1987; 23: 349-353
        • Mackert A.
        • Volz H.P.
        • Stieglitz R.D.
        • Müller-Oerlinghausen B.
        Effect of bright white light on non-seasonal depressive disorder.
        Pharmacopsychiatry. 1990; 23: 151-154
        • National Institute of Mental Health
        12—CGI, Clinical Global Impressions.
        in: Guy W. Bonato R.R. Manual for the ECDEU Assessment Battery. 1970: 12.1-12.6 (rev ed. Chevy Chase, MD)
        • National Institute of Mental Health
        028 CGI, Clinical Global Impressions.
        in: Guy W. ECDEU Assessment Manual for Psychopharmacology. Rockville, MD, 1976: 217-222 (rev ed.)
        • Priebe S.
        Early subjective reactions predicting the outcome of hospital treatment in depressive patients.
        Acta Psychiatr Scand. 1987; 76: 134-138
        • Rao M.L.
        • Müller-Oerlinghausen B.
        • Mackert A.
        • Volz H.P.
        • Franke N.
        • Stieglitz R.D.
        Treatment with artificial light ameliorates depressive symptoms concomitantly with attenuation of blood serotonin but not serum melatonin in patients with non-seasonal affective disorder.
        Biol Psychiatry. 1991; (in press)
        • Rosenthal N.E.
        • Sack D.A.
        • Gillin J.C.
        • et al.
        Seasonal affective disorder—a prescription of the syndrome and preliminary findings with the therapy.
        Arch Gen Psychiatry. 1984; 41: 72-80
        • Rosenthal N.E.
        • Sack D.A.
        • Carpenter C.J.
        • Parry B.L.
        • Mendelson W.B.
        • Wehr T.A.
        Antidepressant effects of light in seasonal affective disorder.
        Am J Psychiatry. 1985; 142: 163-170
        • Rosenthal N.E.
        • Sack D.A.
        • Jacobsen F.M.
        • et al.
        Melatonin in seasonal affective disorder and phototherapy.
        J Neural Trans. 1986; 21 (Suppl): 257-267
        • Spitzer R.L.
        • Endicott J.
        • Robbins R.
        3rd ed. Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders. Biometrics Research, New York1977
        • Terman M.
        • Quitkin F.M.
        • Terman J.S.
        • Stewart J.W.
        • McGrath P.J.
        The timing of phototheraphy: effects on clinical response and the melatonin cycle.
        Psychopharmacol Bull. 1987; 23: 354-357
        • Terman M.
        • Terman J.S.
        • Schalger D.
        • Quitkin F.M.
        Efficacy of 10,000 lux light therapy.
        in: Paper presented at the World Psychiatric Association meetings, Washington DC1988
        • Thompson C.
        • Isaacs G.
        • Stainer S.
        • Miles A.
        Seasonal affective disorder-phototherapy and salivary melatonin.
        Abstract N°263. 1986; (15.CINP in Puerto Rico)
        • Volz H.P.
        • Mackert A.
        • Stieglitz R.D.
        • Müller-Oerlinghausen B.
        Effect of bright white light therapy on non-seasonal depressive disorder. Preliminary results.
        J Affective Disord. 1990; 19: 15-21
        • von Zerssen Dv.
        Clinical Self-Rating Scales (CSRS) of the Munich psychiatric information system (PSYCHIS München).
        in: Assessment of Depression. Springer, Berlin1986: 270-303
        • Wehr T.A.
        • Jacobsen F.M.
        • Sack D.A.
        • Arendt J.
        • Tamarkin L.
        • Rosenthal N.E.
        Phototherapy of seasonal affective disorder.
        Arch Gen Psychiatry. 1986; 43: 870-875
        • Wehr T.A.
        • Skwerer R.G.
        • Jacobsen F.M.
        • Sack D.A.
        • Rosenthal N.E.
        Eye- vs. skin-phototherapy of seasonal affective disorder.
        Am J Psychiat. 1987; 144: 753-757
        • Wirz-Justice A.
        • Bucheli B.
        • Graw P.
        • Kielholz P.
        • Fisch H.U.
        • Woggon B.
        Light treatment of seasonal affective disorder in Switzerland.
        Acta Psychiatr Scand. 1986; 74: 193-204
        • Wirz-Justice A.
        • Schmid A.C.
        • Graw P.
        • et al.
        Dose relationships of morning bright white light in seasonal affective disorders (SAD).
        Experimentia. 1987; 43: 574-576
        • Yerevanian B.I.
        • Anderson J.L.
        • Grota L.J.
        • Bray M.
        Effects of bright incandescent light on seasonal and non-seasonal major depressive disorder.
        Psychiatr Res. 1986; 18: 355-364

      Article info

      Publication history

      Received in revised form: February 27, 1991
      Received: September 2, 1990

      Identification

      DOI: https://doi.org/10.1016/0006-3223(91)90110-8

      Copyright

      © 1991 Published by Elsevier Inc.

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