Brief report| Volume 28, ISSUE 4, P365-368, August 15, 1990

Download started.


Is decreased imipramine binding by platelet membranes in major depression associated with plasma autoantibodies to imipramine binding sites?

      This paper is only available as a PDF. To read, Please Download here.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Blecher M.
        Receptors, antibodies, and disease.
        Clin Chem. 1984; 30: 1137-1156
        • Mendlewicz J.
        • Sevy S.
        Genetic and immunological factors in affective disorders and schizophrenia.
        Prog Brain Res. 1986; 65: 1-14
        • Nemeroff C.B.
        • Knight D.L.
        • Krishnan K.R.R.
        • et al.
        Marked reduction in the number of platelet-tritiated imipramine binding sites in geriatric depression.
        Arch Gen Psychiatry. 1988; 45: 919-923
        • Nemeroff C.B.
        • Krishnan K.R.R.
        • Blazer D.G.
        • Knight D.L.
        • Benjamin D.
        • Meyerson L.R.
        Elevated plasma concentrations of α1-acid glycoprotein: A puttive endogenous inhibitor of the 3H-imipramine site in depressed patients.
        Arch Gen Psychiatry. 1990; (in press)
        • Paul S.M.
        • Rehavi M.
        • Skolnick P.
        • Ballenger J.C.
        • Goodwin F.K.
        Depressed patients have decreased binding of tritiated imipramine to platelet serotonin “transporter”.
        Arch Gen Psychiatry. 1981; 38: 1315-1317
        • Raisman R.
        • Sechter D.
        • Briley M.S.
        • Zarifian E.
        • Langer S.Z.
        High affinity 3H imipramine binding in platelets from untreated and depressed patients compared to healthy volunteers.
        Psychopharmacology. 1981; 75: 368-371
        • Suranyi-Cadotte B.
        • Quirion R.
        • McQuade P.
        • et al.
        Platelet 3H imipramine binding: A state-dependent-marker in depression.
        Prog Neuropsychopharmacol Biol Psychiatry. 1984; 8: 737-741