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Research Article| Volume 28, ISSUE 4, P339-348, August 15, 1990

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Up-regulatory effect of estrogen on platelet 3H-imipramine binding sites in surgically menopausal women

  • Barbara B. Sherwin
    Correspondence
    Address reprint requests to Dr. Barbara B. Sherwin. McGill University, Department of Psychology, 1205 Docteur Penfield Avenue, Montreal, Quebec, H3A 1B1, Canada.
    Affiliations
    From the Department of Psychology, McGill University and Department of Obstetrics and Gynecology, The Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Canada
    Search for articles by this author
  • Barbara E. Suranyi-Cadotte
    Affiliations
    the Douglas Hospital Research Center and Department of Psychiatry McGill University, Montreal, Canada
    Search for articles by this author
DOI:https://doi.org/10.1016/0006-3223(90)90661-K
Up-regulatory effect of estrogen on platelet 3H-imipramine binding sites in surgically menopausal women
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      Abstract

      Although depressive symptoms occur in a considerable number of women following a decrease in circulating estrogen levels, a biological correlate of these modd changes has not been identified. In a prospective, double-blind, cross-over investigation of surgically menopausal women, an increase in the number of tritiated imipramine binding sites on platelets and an improvement of mood occurred with estrogen treatment and were reversed when placebo was administered. In vitro studies indicated that this effect was not due to a direct interaction of the steroid with the imipramine binding site at the same concentrations of estradiol induced in the in vivo study. Together with other evidence, these findings suggest that pharmacological but not physiological doses of estrogen can enhance the density of tritiated imipramine binding sites on platelets in women.
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      Article info

      Publication history

      Received in revised form: January 31, 1990
      Received: November 7, 1989

      Footnotes

      ☆Supported by Grant #MA-8707 from the Medical Research Council of Canada awarded to B.B. Sherwin.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(90)90661-K

      Copyright

      © 1990 Published by Elsevier Inc.

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