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Research Article| Volume 28, ISSUE 4, P325-338, August 15, 1990

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Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuse

  • Howard B. Moss
    Correspondence
    Address reprint requests to Dr. Howard B. Moss, Western Psychiatric Institute 3811 O'Hara St., Pittsburgh, PA 15213-2593.
    Affiliations
    From the Comprehensive Alcohol and Drug Abuse Program, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
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  • Jeffrey K. Yao
    Affiliations
    Department of Psychiatry, University of Pittsburgh School of Medicine, Department of Veterans Affairs Medical Center-Highland Drive, Pittsburgh, PA, USA
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  • George L. Panzak
    Affiliations
    From the Comprehensive Alcohol and Drug Abuse Program, Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, USA
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DOI:https://doi.org/10.1016/0006-3223(90)90660-T
Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuse
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      Abstract

      In order to assess the possibility of altered serotonergic responsivity in antisocial personality disorder with substance abuse (ASP), 15 men with ASP and 12 controls were challenged with the serotonin agonist, m-chlorophenylpiperazine (m-CPP), and prolactin and cortisol responses were evaluated. Psychometric measures of hostility and aggression, impulsivity, cognitive tempo, and various aspects of sociopathy were also obtained. ASP subjects had a significantly reduced prolactin response to m-CPP compared with controls, and a significantly greater cortisol response. The prolactin responses showed a significant inverse correlation with measures of assaultive aggression, hypophoria (negative affects), and increased needs. There was no significant correlation found between cortisol responses and any of the psychometric measures. Impulsivity as characterized either by behavioral self-report or measurement of cognitive tempo did not correlate with either prolactin or cortisol responses. A discriminant function analysis depicted ASP subjects as displaying resentment towards others and having poor test-taking effici ency, heightened irritability, and diminished prolactin response to m-CPP. Using these four criteria, nearly 93% of subjects were successfully classified. These results suggest that altered serotonergic function is associated with assaultiveness and dysphoria but not impulsivity in individuals with ASP.
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      Article info

      Publication history

      Received in revised form: January 16, 1990
      Received: November 2, 1989

      Footnotes

      ☆Supported in part by NIDA Center P50-DA5605.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(90)90660-T

      Copyright

      © 1990 Published by Elsevier Inc.

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