Research Article| Volume 28, ISSUE 4, P308-314, August 15, 1990

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Comparison of growth hormone response after clonidine and insulin hypoglycemia in affective illness

  • Jay D. Amsterdam
    Address reprint requests to : Jay D. Amsterdam, M.D., Depression Research Unit, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    From the Depression Research Unit, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
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  • Greg Maislin
    From the Depression Research Unit, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
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      Abnormal growth hormone (GH) responses have been observed after several neuroendocrine challenge tests. In the present study, we examined the relationship between GH response after clonidine and insulin administration within the same subject to see if consistent response patterns were evident. Though there was a significant reduction in the mean GH response after clonidine (p=0.0002), similar differences were not observed after insulin (p=0.10). Furthermore, there were no apparent within-subject correlations for GH response between the clonidine and insulin challenge tests. Although the present findings indicate an inherent variability in GH response patterns after different neuroendocrine challenge tests, it appears from prior studies that GH may be more consistently blunted after clonidine in depression when compared to other GH provocative tests.


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