Advertisement
Research Article| Volume 28, ISSUE 4, P297-307, August 15, 1990

Download started.

Ok

Suppression of conditioned avoidance behavior by the local application of (−)sulpiride into the ventral, but not the dorsal, striatum of the rat

DOI:https://doi.org/10.1016/0006-3223(90)90657-N
Suppression of conditioned avoidance behavior by the local application of (−)sulpiride into the ventral, but not the dorsal, striatum of the rat
Previous ArticleEffect of yohimbine on plasma homovanillic acid in panic disorder patients and normal controls
Next ArticleComparison of growth hormone response after clonidine and insulin hypoglycemia in affective illness
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      The local application of (−)sulpiride, 200 ng side−1, into the nucleus accumbens produced a suppression of conditioned avoidance behavior in male rats, 10 and 90 min after injection. The decrease in avoidance behavior was accompained by a decrease in motor activity, as evidenced by changes in the number of intertrial crosses. When injected into the dorsolateral neostriatum, or the amygdala, (−)sulpiride produced a suppression of conditioned avoidance behavior at the 90-min time interval only. Considering diffusion from the injection site, as indicated by an increase in local dopamine turnover [(DO-PAC+HVA) DA−1], the effects obtained in the dorsolateral neostriatum, and possibly also the amygdala, 90 min after injection could be due to diffusion to the nucleus accumbens. The local application of (-) sulpiride into the posterior neostriatum, or into the prefrontal cortex, produced no statistically significant effect on conditioned avoidance behavior 10 or 90 min after injection. It is concluded that the performance of conditioned avoidance behavior in the rat is critically dependent on an intact dopaminergic neurotransmission in the nucleus accumbens or adjacent areas of the ventral striatum.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Ahlenius S.
        An analysis of behavioral effects of produced by drug-induced change of dopaminergic neurotransmission in the brain.
        Scand J Psychol. 1979; 20: 59-64
        • Ahlenius S.
        • Engel J.
        Behavioral effects of haloperidol after tyrosine hydroxylase inhibition.
        Eur J Pharmacol. 1971; 15: 187-192
        • Ahlenius S.
        • Hillegaart V.
        • Fowler C.J.
        • Magnusson O.
        Ipsilateral turning after local application of (−)sulpiride into the dorsal, but not the ventral striatum of the rat.
        in: Crossman A.R. Sambrook M.A. Neural Mechanisms in Disorders of Movement. John Libbey, London1989
        • Ahlenius S.
        • Hillegaart V.
        • Thorell G.
        • Magnusson O.
        • Fowler C.
        Suppression of exploratory locomotor activity and increase in dopamine turnover following the local application of cis-flupenthixol into limbic projection areas of the rat striatum.
        Brain Res. 1987; 402: 131-138
        • Ahlheid G.F.
        • Heimer L.
        New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: The striatopallidal, amygdaloid, and corticopetal components of substantia innominata.
        Neuroscience. 1988; 27: 1-39
        • Andén N.-E.
        Dopamine turnover in the corpus striatum and the limbic system after treatment with neuroleptic and anti-acetylcholine drugs.
        J Pharmacol. 1972; 24: 905-906
        • Baldessarini R.J.
        Drugs and the treatment of psychiatric disorders.
        in: Goodman L.S. Gilman A. The Pharmacological Basis of Therapeutics. MacMillan, New York1985
        • Beckstead R.M.
        Convergent thalamic and mesencephalic projections to the anterior medial cotex in the rat.
        J Comp Neurol. 1976; 166: 403-416
        • Buchsbaum M.S.
        Positron emission tomography in schizophrenia.
        in: Meltzer H.Y. Psychopharmacology. Raven Press, New York1987
        • Cook L.
        • Weidley E.
        Behavioral effects of some psychopharmacological agents.
        Ann NY Acad Sci. 1957; 66: 740-752
        • Courvoisier S.
        Pharmacodynamic basis for the use of chlopromazine in psychiatry.
        J Clin Exp Psychopathol Q Rev Psychiatr Neurol. 1956; 17: 25-37
        • Costall B.
        • Naylor R.
        Assessment of the test procedures used to analyse neuroleptic action.
        Rev Pure Appl Pharmacol Sci. 1980; 1: 3-83
        • Davies J.A.
        • Jackson B.
        • Redfern P.H.
        The effect of anti-parkinsonian drugs on haloperidol-induced inhibition of the conditioned-avoidance response in rats.
        Neuropharmacology. 1973; 12: 735-740
        • Fantin G.
        • Bottecchia D.
        Effect of nucleus accumbens destruction in the rat.
        Experientia. 1984; 40: 573-575
        • Fibiger H.C.
        • Zis A.P.
        • Phillips A.G.
        Haloperidol-induced disruption of conditioned avoidance responding: Attenuation by prior training or by anticholinergic drugs.
        Eur J Pharmacol. 1975; 30: 309-314
        • Fink J.S.
        • Smith G.P.
        Mesolimbic and mesocortical dopaminergic neurons are necessary for normal exploratory behavior in rats.
        Neurosci Lett. 1980; 17: 61-65
        • Goldberg M.E.
        • Johnsson H.E.
        • Knaak J.B.
        Inhibition of discrete avoidance behavior by three anticholinesterase agents.
        Psychopharmacologia. 1965; 7: 72-76
        • Hanson H.M.
        • Stone C.A.
        • Witoslawski J.J.
        Antagonism of the antiavoidance effects of various agents by anticholinergic drugs.
        J Pharmacol Exp Ther. 1970; 173: 117-124
        • Hollander M.
        • Wolfe D.A.
        Nonparametric statistical methods.
        Wiley & Sons, New York1973
        • Ingvar D.H.
        Evidence for frontal/prefrontal cortical dysfunction in chronic schizophrenia: The phenomenon of “hypofrontality”.
        in: Helmchen H. Henn F.A. Biological Perspectives of Schizophrenia. Wiley, Chichester1987: 201-211
        • Iversen S.D.
        Behavioral effects of manipulation of basal ganglia neurotransmitters.
        in: Ciba Foundation Symposium 107. Functions of the Basal Ganglia. Pitman, London1983: 183-200
        • Janssen P.A.J.
        • Niemegeers C.J.E.
        • Schellekens K.H.L.
        Is is possible to predict the clinical effects of neuroleptic drugs (major tranquilizers) from animal data? Part III. The subcutaneous and oral activity in rats and dogs of 56 neuroleptic drugs in the jumping box test.
        Arzneimittelforschung. 1966; 16: 339-346
        • Kehne J.H.
        • Sant W.W.
        • Sorenson C.A.
        The effects of radio-frequency lesions of the nucleus accumbens on d-amphetamine-induced locomotor and rearing behavior in rats.
        Psychopharmacology. 1981; 75: 363-367
        • Kelley A.E.
        • Domesick V.B.
        • Nauta W.J.H.
        The amygdalostriatal projection in the rat—An anatomical study by anterograde and retrograde tracing methods.
        Neuroscience. 1982; 7: 615-630
        • Kelly P.H.
        • Seviour P.W.
        • Iversen S.D.
        Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum.
        Brain Res. 1975; 94: 507-522
        • Koob G.F.
        • Hervé S.
        • Herman J.P.
        • Le Moal M.
        Neuroleptic-like disruption of the conditioned avoidance response requires destruction of both the mesolimbic and nigrostriatal dopamine systems.
        Brain Res. 1984; 303: 319-329
        • Li C.C.
        Introduction to Experimental Statistics.
        in: McGraw-Hill, New York1964: 207-226
        • Lindvall O.
        • Björklund A.
        Organisation of catecholamine neurons in the rat central nervous system.
        in: Handbook of Psychopharmacology. vol. 9. Plenum Press, New York1978
        • Magnusson O.
        • Nilsson L.B.
        • Westerlund D.
        Simultaneous determination of dopamine, DOPAC and homovanillic acid. Direct injection of supernatants from brain tissue homogenates in a liquid chromatography-electrochemical detection system.
        J Chromatogr. 1980; 221: 237-247
        • Mohringe B.
        • Magnusson O.
        • Thorell G.
        • Fowler C.J.
        Seasonal variation in the stability of monoamines and their metabolites in perchloric acid as measured by high-performance liquid chromatography.
        J Chromatogr. 1986; 361: 291-299
        • Paxinos G.
        • Watson C.
        The Rat Brain in Stereotaxic Coordinates.
        Academic Press, London1986
        • Nishibe Y.
        • Matsuo Y.
        • Yoshizaki T.
        • Eigyo M.
        • Shiomi T.
        • Hirose K.
        Differential effects of sulpiride and metoclopramide on brain homovanillic acid levels and shuttle box avoidance after systemic and intracerebral administration.
        Naunyn Schmiedebergs Arch Pharmacol. 1982; 321: 190-194
        • Reynolds G.P.
        Increased concentrationsand lateral asymmetry of amygdala dopamine in schizophrenia.
        Nature. 1983; 305: 527-529
        • Seiden L.S.
        • Carlsson A.
        Temporary and partial antagonism by L-DOPA of reserpine-induced suppression of a conditioned avoidance response.
        Psychopharmacology (Berlin). 1963; 4: 418-423
        • Svensson L.
        • Ahlenius S.
        Suppressionof exploratory locomotor activity by the local application of dopamine of l-noradrenaline to the nucleus accumbens of the rat.
        Pharmacol Biochem Behav. 1983; 19: 693-699
        • Thierry A.M.
        • Stinus L.
        • Blanc G.
        • Glowinski J.
        Some evidence for the existence of dopaminergic neurons in the rat cortex.
        Brain Res. 1973; 50: 230-234
        • Thompson R.
        A behavioral atlas of the rat brain.
        Oxford University Press, New York1978
        • Trabucchi M.
        • Longoni R.
        • Fresia P.
        • Spano P.F.
        Sulpiride: A study of the effects on dopamine receptors in rat neostriatum and limbic forebrain.
        Life Sci. 1975; 17: 1551-1556
        • van Ree J.M.
        • Wolterink G.
        Injection of low doses of apomorphine into the nucleus accumbens of rats reduces locomotor activity.
        Eur J Pharmacol. 1981; 72: 107-111
        • Verhave T.
        • Owen Jr., J.E.
        • Robbins E.B.
        Effects of chlorpromazine and secobarbital on avoidance and escape behavior.
        Arch Intern Pharmacol. 1958; 116: 45-53
        • Yoshida M.
        • Sakai M.
        • Kani K.
        • Nagatsu I.
        • Tanaka M.
        The dopaminergic innervation as observed by immunochemistry using anti-dopamine serum in the rat cerebral cortex.
        Experientia. 1988; 44: 699-702

      Article info

      Publication history

      Received in revised form: October 24, 1989
      Received: June 17, 1989

      Identification

      DOI: https://doi.org/10.1016/0006-3223(90)90657-N

      Copyright

      © 1990 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX