Brief report| Volume 28, ISSUE 12, P1061-1064, December 15, 1990

Triiodothyronine potentiation of tricyclic antidepressant treatment in patients with panic disorder

  • Murray B. Stein
    Section on Anxiety and Affective Disorders, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
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  • Thomas W. Uhde
    Address reprint requests to Thomas W. Uhde, M.D., Section on Anxiety and Affective Disorders, BPB, NIMH, 9000 Rockville Pike, Bethesda, MA 20892.
    Section on Anxiety and Affective Disorders, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
    Search for articles by this author
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        • Earle B.V.
        Thyroid hormone and tricyclic antidepressants in resistant depression.
        Am J Psychiatry. 1970; 126: 1667-1669
        • Gewirtz G.R.
        • Malaspina D.
        • Hatterer J.A.
        • et al.
        Occult thyroid dysfunction in patients with refractory depression.
        Am J Psychiatry. 1988; 145: 1012-1014
        • Gitlin M.J.
        • Weiner H.
        • Fairbanks L.
        • et al.
        Failure of T3 to potentiate tricyclic antidepressant response.
        J Affective Disord. 1987; 38: 106-113
        • Goodwin F.K.
        • Prange Jr., A.J.
        • Post R.M.
        • et al.
        Potentiation of antidepressant effects of l-triiodothyronine in tricyclic nonresponders.
        Am J Psychiatry. 1982; 139: 34-38
        • Joffe R.T.
        • Singer W.
        A comparison of triiodothyronine and thyroxine in the potentiation of tricyclic antidepressants in depressed patients.
        Psychiatry Res. 1990; (in press)
        • Loosen P.T.
        • Prange Jr., A.J.
        Serum thyrotrpin response to thyrotropin-releasing hormone in psychiatric patients: A review.
        Am J Psychiatry. 1982; 139: 405-406
        • Lydiard R.B.
        • Ballenger J.C.
        Antidepressants in panic disorder and agoraphobia.
        J Affective Disord. 1987; 13: 153-168
        • Prange Jr., A.J.
        • Loosen P.A.T.
        • Wilson I.C.
        • et al.
        The therapeutic use of hormones of the thyroid axis in depression.
        in: Post R.M. Ballenger J.C. Neurobiology of Mood Disorders. Williams & Wilkins, Baltimore1984: 311-322
        • Sheehan D.V.
        • Coleman J.H.
        • Greenblatt D.J.
        • et al.
        Some biochemical correlates of panic attacks with agoraphobia and their response to a new treatment.
        J Clin Psychopharmacol. 1984; 4: 66-75
        • Spielberger C.D.
        • Gorsuch R.L.
        • Lushene R.E.
        State-Tra't Anxiety (STAI) Manual.
        in: Consulting Psychologists Press, Palo Alto, CA1970: 24
        • Stein M.B.
        • Uhde T.W.
        Endocrine, cardiovascular, and behavioral effects of intravenous protirelin in patients with panic disorders.
        Arch Gen Psychiatry. 1990; (in press)
        • Targum S.D.
        • Greenburg R.D.
        • Harmon R.L.
        • et al.
        Thyroid hormone and the TRH stimulation test in refractory depression.
        J Clin Psychiatry. 1984; 45: 345-346
        • Thase M.E.
        • Kupfer D.J.
        • Jarrett D.B.
        Treatment of imipramine-resistant recurrent depression: I. An open clinical trial of adjunctive l-triiodothyronine.
        J Clin Psychiatry. 1989; 50: 385-388
        • Tsutsui S.
        • Yamazaki Y.
        • Namba T.
        • et al.
        Combined therapy of T3 and antidepressants in depression.
        J Int Med Res. 1979; 7: 138-146
        • Uhde T.W.
        • Stein M.B.
        Thyroid function in panic disorder.
        Abstracts of the American College of Neuropsychopharmacology. 1989; : 183