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Research Article| Volume 28, ISSUE 12, P1037-1048, December 15, 1990

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Monoaminergic neural transplants prevent learned helplessness in a rat depression model

  • Jacqueline Sagen
    Correspondence
    Address reprint requests to Dr. Jacqueline Sagen, Department of Anatomy and Cell Biology, University of Illinois at Chicago, 808 S. Wood Street, Chicago, IL 60612, USA.
    Affiliations
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, 808 S. Wood Street, Chicago, IL 60612, USA.
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  • Caryl E. Sortwell
    Affiliations
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, 808 S. Wood Street, Chicago, IL 60612, USA.
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  • George D. Pappas
    Affiliations
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, 808 S. Wood Street, Chicago, IL 60612, USA.
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DOI:https://doi.org/10.1016/0006-3223(90)90604-Z
Monoaminergic neural transplants prevent learned helplessness in a rat depression model
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      Abstract

      Current theories of the etiology of depression implicate disturbances and imbalances in the junction of monoaminergic systems, particularly involving serotonin and norepinephrine. Neural transplantation is a potential approach towards restoring balanced functioning in the central nervous system. The purpose of the present study was to determine the utility of transplanting monoamine-producing cells into the brain to alleviate behavioral depression. Serotonin-containing pineal gland tissue, catecholamine-containing adrenal medullary tissue, a combination of both, and a control of striated muscle tissue were implanted into the frontal neocortex of adult rats. The ability of these grafts to prevent the development of learned helplessness, a widely accepted model for depression, was assessed 6–8 weeks following transplantation. The monoamine-containing transplants, but not the control transplants, were able to prevent the development of learned helplessness. Immunocytochemical and ultrastructural studies revealed that the grafted monoaminergic tissues survived and continued to produce high levels of monoamines. These results suggest that neural transplants may provide a long-term local source of monoamines as a potentially new approach for alleviating some forms of depression.
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      References

        • Anisman H.
        • Zacharko R.M.
        Behavioral and neurochemical consequences associated with stressors.
        Ann NY Acad Sci. 1986; 467: 205-225
        • Arletti H.
        • Bertolini A.
        Oxytocin acts as an antidepressant in two animal models of depression.
        Life Sci. 1987; 41: 1725-1730
        • Azmitia E.C.
        • Bjorkland A.
        Cell and Tissue Transplantation into the Adult Brain.
        in: Ann NY Acad Sci, New York1987: 813
        • Banerjee S.P.
        • Kung L.S.
        • Riggi S.J.
        • Chanda S.K.
        Development of beta-adrenergic receptor subsensitivity by antidepressants.
        Nature. 1977; 268: 455-456
        • Bankiewicz K.S.
        • Plunkett R.J.
        • Jacobowitz D.M.
        • Kopin I.J.
        • Cummins A.C.
        • Oldfield E.H.
        Implantation into the head of caudate nucleus.
        in: Stein D.G. Restorative Neurology and Neuroscience. Third International Symposium on Neural Transplantation. Elsevier, New York1989: 10
        • Benson B.
        • Reynolds W.D.
        Norepinephrine stimulated release of pineal serotonin may be mediated by alpha adrenergic receptors.
        Soc Neurosci Abstracts. 1988; 14: 25
        • Bohn J.C.
        • Cupit L.
        • Marciano F.
        • Gash M.D.
        Adrenal medulla grafts enhance recovery of striatal dopaminergic fibers.
        Science. 1987; 237: 913-916
        • Brown R.
        • Kocsis J.H.
        • Caroff S.
        • Amsterdam J.
        • Winokur A.
        • Stokes P.E.
        • Frazer A.
        Differences in nocturnal melatonin secretion between melancholic depressed patients and control subjects.
        Am J Psychiatry. 1985; 142: 811-816
        • Bryant S.G.
        • Brown C.S.
        Current concepts in clinical therapeutics: Major affective disorders.
        Clin Pharm. 1986; 5 (part 1): 303-318
        • Charney D.S.
        • Menkes D.B.
        • Heninger G.R.
        Receptor sensitivity and the mechanism of action of antidepressant treatment. Implications for the etiology and therapy of depression.
        Arch Gen Psychiatry. 1981; 10: 1160-1180
        • Claustrat B.
        • Chazot G.
        • Brun J.
        • Jordan P.
        • Sassolas G.
        A chronobiological study of melatonin and cortisol secretion in depressed subjects: Plasma melatonin, a biological marker in major depression.
        Biol Psychiatry. 1984; 19: 1215-1229
        • Collier T.J.
        • Gash D.M.
        • Sladek Jr., J.R.
        Transplantation of norepinephrine neurons into aged rats improves performance of a learned task.
        Brain Res. 1988; 448: 77-87
        • Cooper J.R.
        • Bloom F.E.
        • Roth R.H.
        The Biochemical Basis of Neuropharmacology.
        in: Oxford University Press, New York1986: 323
        • Devoize J.L.
        • Rigal F.
        • Eschalier A.
        • Trolese J.F.
        Naloxone inhibits clomipramine in mouse forced swimming test.
        Eur J Pharmacol. 1982; 78: 229-231
        • Drugan R.C.
        • Ryan S.M.
        • Minor T.R.
        • Maier S.F.
        Librium prevents the analgesia and shuttlebox escape deficit typically observed following inescapable shock.
        Pharmacol Biochem Behav. 1984; 21: 749-754
        • Fuller R.W.
        • Wong D.T.
        Effects of antidepressants on uptake and receptor systems in the brain.
        Prog Neuropsychopharmacol Biol Psychiatry. 1985; 9: 485-490
        • Green A.R.
        • Peralta E.
        • Hong J.S.
        • Mao C.C.
        • Atterwill C.K.
        • Costa E.
        Alterations in GABA metabolism and met-enkephalin content in rat brain following repeated electroconvulsive shock therapy.
        J Neurochem. 1978; 31: 607-611
        • Hellhammer D.H.
        • Rea M.A.
        • Bell M.
        • Belkein L.
        • Ludwig M.
        Learned helplessness: Effects on brain monoamines and the pituitary-gonadal axis.
        Pharmacol Biochem Behav. 1984; 21: 481-485
        • Hughes C.W.
        • Kent C.D.
        • Campbell A.O.
        • Croskell H.
        • Preskorn S.H.
        Cerebral blood flow and cerebrovascular permeability in an inescapable shock (learned helplessness) animal model of depression.
        Pharmacol Biochem Behav. 1984; 21: 891-894
        • Kellar K.J.
        • Cascio C.S.
        • Bergstrom D.A.
        • Butler D.A.
        • Iadorola P.
        Electroconvulsive shock and reserpine: Effects on beta-adrenergic receptors in rat brain.
        J Neurochem. 1981; 37: 830-836
        • Kemmler J.E.
        • Sagen J.
        Increased catecholamine levels in spinal cord superfusates of rats with adrenal medullary implants.
        Soc Neurosci Abstracts. 1989; 15: 1243
        • leshner A.I.
        • Remler H.
        • Biegon A.
        • Samuel D.
        Effects of desmethylimipramine (DMI) in learned helplessness.
        Psychopharmacology. 1979; 66: 207-213
        • Maggi A.
        • U'Prichard D.C.
        • Enna S.J.
        Differential effects of antidepressant treatment on brain monoaminergic receptors.
        Eur J Pharmacol. 1980; 61: 91-98
        • Martin P.
        • Soubrie P.
        • Simon P.
        Noradrenergic and opioid mediation of tricyclic-induced reversal of escape deficits caused by inescapable shock pretreatment in rats.
        Psychopharmacology. 1986; 90: 90-94
        • Martin P.
        • Soubrie P.
        • Simon P.
        The effect of monoamine oxidase inhibitors compared with classical tricyclic antidepressants on learned helplessness paradigm.
        Prog Neuropsychopharmacol Biol Psychiatry. 1987; 11: 1-7
        • McKinney W.T.
        Electroconvulsive therapy and animal models of depression.
        Ann NY Acad Sci. 1986; 462: 65-69
        • Minor R.R.
        • Pelleymounter M.A.
        • Maier S.F.
        Uncontrollable shock, forebrain norepinephrine and stimulus selection during choice escape learning.
        Psychobiology. 1988; 16: 135-145
        • Nair N.P.V.
        • Hariharasubramanian N.
        • Pilapil C.
        Circadian rhythm of plasma melatonin in endogenous depression.
        Prog Neuropsychopharmacol Biol Psychiatry. 1984; 8: 715-718
        • Nilsson O.G.
        • Brundin P.
        • Bjorkland A.
        Amelioration of spatial memory impairments by intrahippocampal grafts of septal and raphe tissue in rats with combined cholinergic and serotonergic denervation of the forebrain.
        in: Stein D.G. Restorative Neurology and Neuroscience. Third Internationa Symposium on Neural Transplantation. Elsevier, New York1989: 43
        • Palmatier M.
        • Plunkett R.
        • Cummins A.
        • Kopin I.
        Neurite-promoting activity is found in the brain of MPTP-treated parkinson monkeys.
        in: Stein D.G. Restorative Neurology and Neuroscience. Third International Symposium on Neural Transplantation. Elsevier, New York1989: 18
        • Pappas G.D.
        • Sagen J.
        The fine structure of chromaffin cell implants in the pain modulatory regions of the rat periaqueductal grey and spinal cord.
        Prog Brain Res. 1988; 78: 513-520
        • Petty F.
        • Sherman A.D.
        Regional aspects of the prevention of learned helplessness by desipramine.
        Life Sci. 1980; 26: 1447-1452
        • Petty F.
        • Sherman A.D.
        A neurochemical differentiation between exposure to stress and the development of learned helplessness.
        Drug Dev Res. 1982; 2: 43-45
        • Richter-Levin G.
        • Segal M.
        Raphe cells grafted into rat hippocampus ameliorate memory deficits caused by combined serotonergic/cholinergic lesions.
        in: Stein D.G. Restorative Neurology and Neuroscience. Third International Symposium on Neural Transplantation. Elsevier, New York1989: 43
        • Rowe V.
        • Parr J.
        Developmental changes in the stimulation of serotonin N-acetyltransferase activity and melatonin synthesis in the rat pineal in monolayer culture.
        J Pharmacol Exp Ther. 1981; 218: 97-102
        • Sagen J.
        • Kemmler J.E.
        Increased levels of Met-enkephalin-like immunoreactivity in the spinal cord CSF of rats with adrenal medullary transplants.
        Brain Res. 1989; 502: 1-10
        • Sagen J.
        • Pappas G.D.
        • Perlow M.J.
        Adrenal medullary tissue transplants in the rat spinal cord reduce pain sensitivity.
        Brain Res. 1986; 384: 189-194
        • Sagen J.
        • Pappas G.D.
        • Pollard H.B.
        Analgesia induced by isolated bovine chromaffin cells implanted in the rat spinal cord.
        in: Proc Natl Acad Sci USA. 83. 1986: 7526-7622
        • Sagen J.
        • Pappas G.D.
        • Perlow M.J.
        Alterations in nociception following adrenal medullary transplants into the rat periaqueductal grey.
        Exp Brain Res. 1987; 67: 373-379
        • Sagen J.
        • Pappas G.D.
        • Perlow M.J.
        Fine structure of adrenal medullary grafts in the pain modulatory regions of the rat periaqueductal grey.
        Exp Brain Res. 1987; 67: 380-390
        • Seligman M.E.P.
        • Beagley G.
        Learned helplessness in the rat.
        J Comp Physiol Psychol. 1975; 88: 534-541
        • Seligman M.E.P.
        • Maier S.F.
        • Geer J.
        The alleviation of learned helplessness in the dog.
        J Abnorm Psychol. 1968; 73: 256-262
        • Sherman A.D.
        • Petty F.
        Neurochemical basis of action of antidepressants on learned helplessness.
        Behav Neural Biol. 1980; 30: 119-134
        • Sherman A.D.
        • Petty F.
        Additivity of neurochemical changes in learned helplessness and imipramine.
        Behav Neural Biol. 1982; 35: 344-353
        • Sherman A.D.
        • Allers G.L.
        • Petty F.
        • Henn F.A.
        A neuropharmacologycally relevant animal model of depression.
        Neuropharmacology. 1979; 18: 891-893
        • Sherman A.D.
        • Sacquitne J.L.
        • Petty F.
        Specificity of the learned helplessness model of depression.
        Pharmacol Biochem Behav. 1982; 16: 449-454
        • Siever L.J.
        • Davis K.L.
        Overview: Toward a dysregulation hypothesis of depression.
        Am J Psychiatry. 1985; 142: 1017-1031
        • Steinlechner S.
        • King T.S.
        • Champney T.H.
        • Richardson B.A.
        • Reiter R.J.
        Pharmacological studies on the regulation of N-acetyltransferase activity and melatonin content of the pineal gland of the syrian hamster.
        J Pineal Res. 1985; 2: 109-119
        • Syvalanti E.
        Monoaminergic mechanisms in affective disorders.
        Med Biol. 1987; 65: 89-96
        • Telner J.I.
        • Singhal R.L.
        Effects of nortriptyline treatment on learned helplessness in the rat.
        Pharmacol Biochem Behav. 1981; 14: 823-826
        • Telner J.I.
        • Singhal R.L.
        Psychiatric progress: The learned helplessness model of depression.
        J Psychiatr Res. 1984; 18: 207-215
        • Walker R.F.
        • Sparks D.L.
        • Slevin J.
        • Rush M.E.
        Temporal effects of norepinephrine on pineal serotonin in vitro.
        J Pineal Res. 1986; 3: 33-40
        • Welner S.A.
        • Boksa P.
        Transplantation of Chromaffin cells to the neocortex of rats with bilateral lesions of nucleus basalis magnocellularis reverses a lesioned-induced deficit in spatial memory.
        in: Stein D.G. Restorative Neurology and Neuroscience. Third International Symposium on Neural Transplantation. Elsevier, New York1989: 41
        • Willner P.
        Validation criteria for animal models of human mental disorders: Learned helplessness as a paradigm case.
        Prog Neuropsychopharmacol Biol Psychiatry. 1986; 10: 677-690
        • Yehuda S.
        • Mostofsky D.I.
        • Bracha T.
        Increased serotonin level via augmented tryptophan diet and its effects on escape learning.
        Int J Neurosci. 1981; 15: 193-196

      Article info

      Publication history

      Received in revised form: May 4, 1990
      Received: January 2, 1990

      Identification

      DOI: https://doi.org/10.1016/0006-3223(90)90604-Z

      Copyright

      © 1990 Published by Elsevier Inc.

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