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Research Article| Volume 28, ISSUE 7, P556-568, October 01, 1990

Neuroendocrinological investigations during sleep deprivation in depression I. Early morning levels of thyrotropin, TH, cortisol, prolactin, LH, FSH, estradiol, and testosterone

DOI:https://doi.org/10.1016/0006-3223(90)90394-H
Neuroendocrinological investigations during sleep deprivation in depression I. Early morning levels of thyrotropin, TH, cortisol, prolactin, LH, FSH, estradiol, and testosterone
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Next ArticleNeuroendocrinological investigations during sleep deprivation in depression II. Longitudinal measurement of thyrotropin, TH, cortisol, prolactin, GH, and LH during sleep and sleep deprivation
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      Abstract

      Measurements of 12 hormones were conducted in patients with major depressive disorder at 8 am on the morning before and at 8 am on the morning after total sleep deprivation (SD). Thyrotropin (TSH), thyroxine (T4), triiodothyronine (T3), and free T3 (fT3) were measured in 50 patients, free T4 in 39 patients, reverse T3, cortisol, prolactin, luteinizing hormone, and follicle-stimulating hormone in 21, estradiol in 20 (women), and testosterone in 14 (men). After SD, there was a significant rise in TSH, T4, T3, and fT3 concentrations and a significant fall in testosterone levels. The increases in TSH levels were significantly correlated to clinical response. Responders to SD had higher T4, fT4, rT3, and testosterone concentrations before SD. Neither age, gender, polarity, nor antidepressant medication had a clearly significant effect on the response to SD.
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      Article info

      Publication history

      Received in revised form: January 29, 1990
      Received: December 20, 1989

      Footnotes

      ☆First presented at the 42nd Annual convention of the Society of Biological Psychiatry, Chicago, May 6–10, 1987.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(90)90394-H

      Copyright

      © 1990 Published by Elsevier Inc.

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