Article| Volume 27, ISSUE 10, P1127-1132, May 15, 1990

Download started.


Urinary chromatographic profiles in schizophrenia

      This paper is only available as a PDF. To read, Please Download here.


      In a series of articles, Trygstad et al. (1980) suggested that specific patterns of peptide excretion and increased levels of peptide material are found by chromatographic analysis of the urine of patients with a variety of psychiatric illness including schizophrenia. As these results have not been independently replicated in another laboratory, we conducted an investigation of urine samples from 5 DSM-III classified schizophrenic patients and 4 normal subjects using the techniques described by the Norwegian group, and with a series of modifications. The chromatographic profiles obtained differ widely from those reported by Trygstad et al. No significant differences were detected between patients with schizophrenia and controls. The methods used by Trygstad et al. are complex and we have defined several parts of the methods which are subject to variability. Our findings lend no support to the view that patients with psychiatric illness can be readily distinguished from normal subjects by the amount or profile of peptide excretion in urine.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Israngkun P.
        • Patel S.T.
        • Newman H.A.I.
        • Taylor W.A.
        Pattern of urinary putative neuropeptides in control and autistic subjects.
        Clin Chem. 1983; 29: 1287
        • Leggett-Bailey J.
        Techniques in Protein Chemistry.
        in: 2nd revised and expanded edition. Elsevier, Amsterdam1967: 340-341
        • Reichelt K.L.
        • Edminson P.D.
        • Toft K.G.
        Urinary peptides in schizophrenia and depression.
        Stress Med. 1985; 1: 169-181
        • Reichelt K.L.
        • Hole K.
        • Hamberger A.
        • et al.
        Biologically active peptide-containing fractions in schizophrenia and childhood autism.
        Adv Biochem Psychopharmacol. 1981; 28: 627-643
        • Saelid G.
        • Haug J.O.
        • Heiberg T.
        • Reichelt K.L.
        Peptide-containing fractions in depression.
        Biol Psychiatry. 1985; 20: 245-256
        • Trygstad O.E.
        • Reichelt K.L.
        • Foss I.
        • et al.
        Patterns of peptides and protein-associated peptide complexes in psychiatric disorders.
        Br J Psychiatry. 1980; 136: 59-72