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Abstract
In a series of articles, Trygstad et al. (1980) suggested that specific patterns of
peptide excretion and increased levels of peptide material are found by chromatographic
analysis of the urine of patients with a variety of psychiatric illness including
schizophrenia. As these results have not been independently replicated in another
laboratory, we conducted an investigation of urine samples from 5 DSM-III classified
schizophrenic patients and 4 normal subjects using the techniques described by the
Norwegian group, and with a series of modifications. The chromatographic profiles
obtained differ widely from those reported by Trygstad et al. No significant differences
were detected between patients with schizophrenia and controls. The methods used by
Trygstad et al. are complex and we have defined several parts of the methods which
are subject to variability. Our findings lend no support to the view that patients
with psychiatric illness can be readily distinguished from normal subjects by the
amount or profile of peptide excretion in urine.
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References
- Pattern of urinary putative neuropeptides in control and autistic subjects.Clin Chem. 1983; 29: 1287
- Techniques in Protein Chemistry.in: 2nd revised and expanded edition. Elsevier, Amsterdam1967: 340-341
- Urinary peptides in schizophrenia and depression.Stress Med. 1985; 1: 169-181
- Biologically active peptide-containing fractions in schizophrenia and childhood autism.Adv Biochem Psychopharmacol. 1981; 28: 627-643
- Peptide-containing fractions in depression.Biol Psychiatry. 1985; 20: 245-256
- Patterns of peptides and protein-associated peptide complexes in psychiatric disorders.Br J Psychiatry. 1980; 136: 59-72
Article info
Publication history
Received in revised form:
April 6,
1989
Received:
June 8,
1987
Identification
Copyright
© 1990 Published by Elsevier Inc.
