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Article| Volume 27, ISSUE 10, P1116-1126, May 15, 1990

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Postural myoclonus associated with long-term administration of neuroleptics in schizophrenic patients

DOI:https://doi.org/10.1016/0006-3223(90)90048-7
Postural myoclonus associated with long-term administration of neuroleptics in schizophrenic patients
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      Abstract

      Postural myoclonus associated with long-term administration of neuroleptics was demonstrated in schizophrenic patients. Sixty patients who had been taking neuroleptics for more than 3 months were investigated for myoclonus and the relationships between postural myoclonus and age, duration of illness, duration of medication, current daily dose, cumulative dose, occurrence of abnormal finger movement, parkinsonism, and tardive dyskinesia were evaluated. Twenty-three patients (38%) showed postural myoclonus when holding the hands forward with the elbow joints flexed at about 90%. Male patients showed a higher incidence of myoclonus than female patients. Patients with myoclonus had been given significantly higher doses of neuroleptics than those without myoclonus. There was a significant correlation between the occurrence of myoclonus and abnormal finger movement. Electromyographic recordings in 7 patients with prominent myoclonus revealed that arrhythmic jerks occurred in the extensor carpi radialis and posterior deltoid muscles and that the jerks on the left and right side were not synchronized. Clonazepam reduced the frequency of the myoclonic activity.
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      References

        • American Psychiatric Association
        Diagnostic and Statistical Manual of Mental Disorders.
        ed 3. American Psychiatric Association, Washington, DC1980
        • Barnes T.R.E.
        • Weller M.P.I.
        Movement disorders and neuroleptic medication.
        in: Shah N.S. Donald A.G. Movement Disorders. Plenum Press, New York1986: 323-341
        • Bathien N.
        • Koutlidis R.M.
        • Rondot P.
        EMG patterns in abnormal involuntary movements induced by neuroleptics.
        J Neurol Neurosurg Psychiatry. 1984; 47: 1002-1008
        • Biegon A.
        • Reches A.
        • Snyder L.
        • McEwen B.S.
        Serotonergic and noradrenergic receptors in the rat brain: Modulation by chronic exposure to ovarian hormones.
        Life Sci. 1983; 32: 2015-2021
        • Biegon A.
        • Segal M.
        • Samuel D.
        Sex differences in behavioral and thermal responses to pargyline and tryptophan.
        Psychopharmacology. 1979; 61: 77-80
        • Burke R.E.
        • Fahn S.
        • Jankovic J.
        • et al.
        Tardive dystonia: Late-onset and persistent dystonia caused by antipsychotic drugs.
        Neurology. 1982; 32: 1335-1346
        • Davis J.M.
        Comparative doses and costs of antipsychotic medication.
        Arch Gen Psychiatry. 1976; 33: 858-861
        • Delay J.
        • Deniker P.
        Drug-induced extrapyramidal syndromes.
        in: Handbook of Clinical Neurology. vol. 6. John Wiley and Sons, New York1968: 248-266
        • Guy W.
        ECDEU Assessment Manual for Psychopharmacology.
        in: US Department of Health, Education and Welfare, Washington, DC1976: 534-537
        • Jenner P.
        • Pratt J.A.
        • Marsden C.D.
        Mechanism of action of clonazepam in myoclonus in relation to effects on GABA and 5-HT.
        in: Advances in Neurology. vol. 43. Raven Press, New York1986: 629-642
        • Klawans H.L.
        • Carvey P.M.
        • Tanner C.M.
        • Goetz C.G.
        Drug-induced myoclonus.
        in: Advances in Neurology. vol. 43. Raven Press, New York1986: 251-264
        • Klawans H.L.
        • Goetz C.G.
        • Bergen D.
        Levodopa-induced myoclonus.
        Arch Neurol. 1975; 32: 331-334
        • Leavitt S.
        • Tyler H.R.
        Studies in asterixis.
        Arch Neurol. 1964; 10: 360-368
        • Olsen R.W.
        GABA-benzodiazepine-barbiturate receptor interactions.
        J Neurochem. 1981; 37: 1-13
        • Polizos P.
        • Engelhardt D.M.
        • Hoffman S.P.
        Neurological consequences of psychotropic drug withdrawal in schizophrenic children.
        J. Austism Child Schizo. 1973; 3: 247-253
        • Saad S.F.
        The effects of ovariectomy on the γ-aminobutyric acid content in the cerebral hemispheres of young rats.
        J Pharm Pharmacol. 1970; 22: 307-308
        • Schipior P.G.
        An unusual case of antihistamine intoxication.
        J Pediatrics. 1967; 71: 589-591
        • Schooler N.R.
        • Kane J.M.
        Research diagnosis for tardive dyskinesia.
        Arch Gen Psychiatry. 1982; 39: 486-487
        • Shiraki H.
        • Okumura A.
        • Oyanagi S.
        Neuropathology of “grumose degeneration” of the cerebellar dentate nucleus with special reference to certain neurotoxic disorders and other pathological processes.
        in: Neurotoxicology. vol. 1. Raven Press, New York1977: 43-55
        • Smith J.M.
        • Dunn D.D.
        Sex differences in the prevalence of severe tardive dyskinesia.
        Am J Psychiatry. 1979; 136: 1080-1082
        • Tarsy D.
        • Baldessarini R.J.
        Movement disorders induced by psychotherapeutic agents: Clinical features, pathophysiology, and management.
        in: Shah N.S. Donald A.G. Movement Disorders. Plenum Press, New York1986: 365-389
        • Tominaga T.
        • Fukuzako H.
        • Izumi K.
        • et al.
        Tardive myoclonus.
        Lancet. 1987; i: 322
        • Wallis C.J.
        • Luttge W.G.
        Influence of estrogen and progesterone on glutamic acid decarboxylase activity in discrete regions of rat brain.
        J Neurochem. 1980; 34: 609-613
        • Weiner W.J.
        • Luby E.D.
        Tardive akathisia.
        J Clin Psychiatry. 1983; 44: 417-419
        • Wolf M.E.
        • Mosnaim A.D.
        Identifying subtypes of tardive dyskinesia.
        Hosp Community Psychiatry. 1984; 35: 828-830
        • Young R.R.
        • Shahani B.T.
        Asterixis: One type of negative myoclonus.
        in: Advances in Neurology. vol. 43. Raven Press, New York1986: 137-156

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      DOI: https://doi.org/10.1016/0006-3223(90)90048-7

      Copyright

      © 1990 Published by Elsevier Inc.

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