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Article| Volume 27, ISSUE 10, P1083-1093, May 15, 1990

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Alpha2-adrenoceptor status in obsessive-compulsive disorder

DOI:https://doi.org/10.1016/0006-3223(90)90045-4
Alpha2-adrenoceptor status in obsessive-compulsive disorder
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      Abstract

      Ten patients with obsessive-compulsive disorder (OCD) and 13 normal control subjects received intravenous infusions of 2 × 10−6 g/kg of clonidine and normal saline on separate days. Responses to the drug relating to plasma growth hormone (GH), 3-methoxy-4-hydroxyphenylglycol (MHPG), heart rate, blood pressure, and several symptoms were determined. Additionally, platelet alpha2-adrenoceptor binding was measured in most of the subjects. GH, MHPG, blood pressure, and heart rate responses to clonidine did not differ between groups. As expected, patients reported more symptoms than normal subjects, and clonidine was sedating for both groups. Patients did not differ from normal subjects in the symptom response to clonidine. The maximum number of binding sites (Bmax) for tritiated clonidine was significantly greater in OCD patients than in normals. This pattern of alpha2-adrenoceptor status is different than the patterns in major depression and panic anxiety.
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      Article info

      Publication history

      Received in revised form: September 22, 1989
      Received: June 6, 1989

      Footnotes

      ☆This research was supported in part by NIMH grant 1RO1MH42736 and in part by Clinical Research Center Grant 5MO1RR00042.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(90)90045-4

      Copyright

      © 1990 Published by Elsevier Inc.

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