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Article| Volume 27, ISSUE 10, P1083-1093, May 15, 1990

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Alpha2-adrenoceptor status in obsessive-compulsive disorder

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      Abstract

      Ten patients with obsessive-compulsive disorder (OCD) and 13 normal control subjects received intravenous infusions of 2 × 10−6 g/kg of clonidine and normal saline on separate days. Responses to the drug relating to plasma growth hormone (GH), 3-methoxy-4-hydroxyphenylglycol (MHPG), heart rate, blood pressure, and several symptoms were determined. Additionally, platelet alpha2-adrenoceptor binding was measured in most of the subjects. GH, MHPG, blood pressure, and heart rate responses to clonidine did not differ between groups. As expected, patients reported more symptoms than normal subjects, and clonidine was sedating for both groups. Patients did not differ from normal subjects in the symptom response to clonidine. The maximum number of binding sites (Bmax) for tritiated clonidine was significantly greater in OCD patients than in normals. This pattern of alpha2-adrenoceptor status is different than the patterns in major depression and panic anxiety.
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      References

        • Albus M.
        • Bondy B.
        • Ackenheil M.
        Adrenergic receptors on blood cells: Relation to the pathophysiology of anxiety.
        Clin Neuropharmacol. 1986; 9: 359-361
        • American Psychiatric Association
        Diagnostic and Statistical Manual of Mental Disorders.
        ed 3. American Psychiatric Association, Washington, DC1980
        • Amsterdam J.D.
        • Maislin G.
        • Skolnick B.
        • Berwish N.
        • Winokur A.
        Multiple hormone responses to clonidine administration in depressed patients and healthy volunteers.
        Biol Psychiatry. 1989; 26: 265-278
        • Brown S.L.
        • Charney D.S.
        • Woods S.W.
        • Heninger G.R.
        • Tallman J.
        Lymphocyte beta-adrenergic receptor binding in panic disorder.
        Psychopharmacology. 1988; 94: 24-28
        • Cameron O.G.
        • Smith C.B.
        • Hollingworth P.J.
        • Nesse R.M.
        • Curtis G.C.
        Platelet alpha2 adrenergic receptor binding and plasma catecholamines: Before and imipramine treatment in patients with panic anxiety.
        Arch Gen Psychiatry. 1984; 41: 1144-1148
        • Carroll B.J.
        • Feinberg M.
        • Smouse P.E.
        • Rawson S.G.
        • Greden J.F.
        The Carroll Rating Scale for Depression I. Development, reliability and validation.
        Br J Psychiatry. 1981; 138: 194-200
        • Carstens M.E.
        • Engelbrecht A.H.
        • Russell V.A.
        • et al.
        Beta-adrenoceptors on lymphocytes of patients with major depressive disorder.
        Psychiatry Res. 1987; 20: 239-248
        • Charney D.S.
        • Heninger G.R.
        Abnormal regulation of noradrenergic function in panic disorders: Effects of clonidine in healthy subjects and patients with agoraphobia and panic disorder.
        Arch Gen Psychiatry. 1986; 43: 1042-1054
        • Charney D.S.
        • Heninger G.R.
        • Breier A.
        Noradrenergic function in panic anxiety: Effects of yohimbine in healthy subjects and patients with agoraphobia and panic disorder.
        Arch Gen Psychiatry. 1984; 41: 751-763
        • Charney D.S.
        • Heninger G.R.
        • Sternberg D.E.
        • Hafstad K.M.
        • Griddings S.
        • Landis D.H.
        Adrenergic receptor sensitivity in depressive illness.
        Arch Gen Psychiatry. 1982; 39: 290-294
        • Charney D.S.
        • Innis R.B.
        • Duman R.S.
        • Woods S.W.
        • Heninger G.R.
        Platelet alpha-2-receptor binding and adnylate cyclase activity in panic disorder.
        Psychopharmacology. 1989; 98: 102-107
        • Checkley S.A.
        • Slade A.P.
        • Shur H.
        Growth hormone and other responses to clonidine in patients with endogenous depression.
        Br J Psychiatry. 1981; 138: 51-55
        • Eriksson E.
        • Eden S.
        • Modigh K.
        Up- and down-regulation of central postsynaptic alpha2 receptors reflected in the growth hormone response to clonidine in reserpine-pretreated rats.
        Psychopharmacology. 1982; 77: 327-331
        • Extein I.
        • Tallman J.
        • Smith C.C.
        • Goodwin F.K.
        Changes in lymphocyte beta-adrenergic receptors in depression and mania.
        Psychiatry Res. 1979; 1: 191-197
        • Feinberg M.
        • Carroll B.J.
        • Smouse P.E.
        • Rawson S.G.
        The Carroll Rating Scale for Depression III. Comparison with other rating instruments.
        Br J Psychiatry. 1981; 138: 205-209
        • Garcia-Sevilla J.A.
        • Hollingsworth P.J.
        • Smith C.B.
        Alpha2-adrenoceptors on human platelets: Selective labelinfg by [3H]clonidine and [3H]yohimbine and competitive inhibition by by antidepressant drugs.
        Eur J Pharmacol. 1981; 74: 329-341
        • Goodman W.K.
        • Price L.H.
        • Rasmussen S.A.
        • Delgado P.
        • Heninger G.R.
        • Charney D.S.
        Efficacy of fluvoxamine in obsessive-compulsive disorder: A double-blind comparison with placebo.
        Arch Gen Psychiatry. 1989; 46: 36-44
        • Grunhaus L.
        Clinical and psychological characteristics of simultaneous panic disorder and major depression.
        Am J Psychiatry. 1988; 145: 1214-1221
        • Grunhaus L.J.
        • Cameron O.G.
        • Pande A.C.
        • Haskett R.F.
        • Hollingsworth P.J.
        • Smith C.B.
        Comorbidity of panic disorder and major depressive disorder: Effects on platelet alpha2 adrenergic receptors.
        Acta Psychiatr Scand. 1989; (in press)
        • Hamilton C.A.
        • Reid J.L.
        Platelet alpha-adrenoreceptors—A validmodel for brain or vascular adrenoreceptor?.
        Br J Clin Pharmacol. 1986; 22: 623-626
        • Hariharan M.
        • VanNoord T.
        • Cameron O.G.
        • Curtis G.C.
        • Ostrow D.G.
        Free 3-methoxy-4-hydroxyphenylglycol determined in plasma by liquid chromatography with coulometric detection.
        Clin Chem. 1989; 35: 202-205
        • Harris R.J.
        A Primer of Multivariate Statistics.
        in: Academic Press, New York1975: 80-84
        • Harris R.J.
        A Primer of Multivariate Statistics.
        in: Academic Press, New York1975: 106-108
        • Hollander E.
        • DeCaria C.
        • Cooper T.
        • Liebowitz M.R.
        Neuroendocrine sensitivity in obsessive-compulsive disorder (Abstract).
        Biol Psychiatry. 1989; 25: 5A
        • Hollander H.
        • Fay M.
        • Cohen B.
        • Campeas R.
        • Gorman J.M.
        • Liebowitz M.R.C.
        Serotonergic and adrenergic sensitivity in obsessive-compulsive disorder: Behavioral findings.
        Am J Psychiatry. 1988; 145: 1015-1017
        • Insel T.R.
        • Murphy D.L.
        • Cohen R.M.
        • Alterman I.
        • Linnoila M.
        • Kilts C.
        Obsessive-compulsive disorder: A double-blind trial of clomipramine and clorgyline.
        Arch Gen Psychiatry. 1983; 40: 605-612
        • Jenike M.A.
        • Buttolph L.
        • Baer L.
        • Ricciardi J.
        • Holland A.
        Open trial of fluoxetine in obsessive-compulsive disorder.
        Am J Psychiatry. 1989; 146: 909-911
        • Karno M.
        • Golding J.
        • Sorenson S.B.
        • Burnam A.
        The epidemiology of obsessive-compulsive disorder in five U.S. communities.
        Arch Gen Psychiatry. 1988; 45: 1094-1099
        • Katona C.L.E.
        • Theodorou A.E.
        • Horton R.W.
        Alpha2-adrenoreceptors in depression.
        Psychiatr Dev. 1987; 2: 129-149
        • Lima D.R.
        • Turner P.
        Propranolol increases reduced beta-receptor function in severely anxious patients.
        Lancet. 1983; ii: 1505
        • Mann J.J.
        • Brown R.P.
        • Halper J.P.
        • et al.
        Reduced sensitivity of lymphocyte beta-adrenergic receptors in patients with endogenous depression and psychomotor agitation.
        N Engl J Med. 1985; 313: 715-720
        • Matussek N.
        • Ackenheil M.
        • Hippius H.
        • et al.
        Effect of clonidine on growth hormone release in psychiatric patients and controls.
        Psychiatry Res. 1980; 2: 25-36
        • Matussek N.
        • Ackenheil M.
        • Herz M.
        The dependence of the clonidine growth hormone test on alcohol drinking habits and the menstrual cycle.
        Psychoneuroendocrinology. 1984; 9: 173-177
        • Nasr S.J.
        • Altman E.G.
        • Rodin M.B.
        • Jobe T.H.
        • Burg B.
        Correlation of the Hamilton and Carroll Depression Rating Scales: A replication study among psychiatric outpatients.
        J Clin Psychiatry. 1984; 45: 167-168
        • Nesse R.M.
        • Cameron O.G.
        • Curtis G.C.
        • McCann D.S.
        • Huber-Smith M.H.
        Adrenergic function in patients with panic anxiety.
        Arch Gen Psychiatry. 1984; 41: 771-776
        • Norman T.R.
        • Kimber N.M.
        • Judd F.K.
        • Burrows G.D.
        • McIntyre I.M.
        Platelet 3H-rauwolscine binding in patients with panic attacks.
        Psychiatry Res. 1987; 22: 43-48
        • Nutt D.J.
        Altered central alpha2-adrenoreceptor sensitivity in panic disorder.
        Arch Gen Psychiatry. 1989; 46: 165-169
        • Nutt D.J.
        • Cowan P.J.
        Monoamine function in anxiety and depression: Information from neuroendocrine challenge tests.
        Hum Psychopharmacol. 1987; 2: 211-220
        • Nutt D.J.
        • Fraser S.
        Platelet binding studies in panic disorder.
        J Affective Disord. 1987; 12: 7-11
        • Nutt D.J.
        • Glue P.
        Aspects of alpha2-adrenoceptor function in normal volunteers.
        Hum Psychopharmacol. 1988; 3: 235-245
        • Pandey G.N.
        • Dysken M.W.
        • Garver D.L.
        • Davis J.M.
        Beat-adrenergic receptor function in affective illness.
        Am J Psychiatry. 1979; 136: 675-678
        • Rapaport M.H.
        • Risch S.R.
        • Gillan J.C.
        • Golshan S.
        • Janowsky D.S.
        Blunted growth hormone response to peripheral infusion of human growth hormone-releasing factor in patients with panic disorder.
        Am J Psychiatry. 1989; 146: 92-95
        • Rasmussen S.A.
        • Goodman W.K.
        • Woods S.W.
        • Heninger G.R.
        • Charney D.S.
        Effects of yohimbine in obsessive-compulsive disorder.
        Psychopharmacology. 1987; 93: 308-313
        • Roy-Byrne P.P.
        • Uhde T.W.
        Panic disorder and major depression: Biological relationships.
        Psychopharmacol Bull. 1985; 21: 551-554
        • Schittecatte M.
        • Charles G.
        • Depauw Y.
        • Mesters P.
        • Wilmotte J.
        Growth hormone response to clonidine in panic disorder patients.
        Psychiatry Res. 1988; 23: 147-151
        • Sevy S.
        • Papadimitriou G.N.
        • Surmont D.W.
        • Goldman S.
        • Mendlewicz J.
        Noradrenergic function in generalized anxiety disorder, major depressive disorder, and healthy subjects.
        Biol Psychiatry. 1989; 25: 141-152
        • Siever L.J.
        • Insel T.R.
        • Jimerson D.C.
        • et al.
        Growth hormone response to clonidine in obsessive-compulsive disorder.
        Br J Psychiatry. 1983; 142: 184-187
        • Siever L.J.
        • Uhde T.W.
        New studies and perspectives on the noradrenergic receptor system in depression: Effects of the alpha2-adrenergic agonist clonidine.
        Biol Psychiatry. 1984; 19: 131-156
        • Siever L.J.
        • Uhde T.W.
        • Insel T.R.
        • et al.
        Biological alterations in the primary affective disorders and other tricyclic-responsive disorders.
        Prog Neuro-Psychopharmacol Biol Psychiatry. 1985; 9: 15-24
        • Spielberger C.D.
        • Gorsuch R.L.
        • Lushene R.E.
        STAI Manual for the State-Trait Anxiety Inventory.
        Consulting Psychologists Press, Palo Alto, California1969
        • Stein M.B.
        • Uhde T.W.
        Cortisol response to clonidine in panic disorder: Comparison with depressed patients and normal controls.
        Biol Psychiatry. 1988; 34: 322-330
        • Turner S.M.
        • Jacob R.G.
        • Beidel D.C.
        • Himmelhoch J.
        Fluoxetine treatment of obsessive-compulsive disorder.
        J Clin Psychopharmacol. 1985; 5: 207-212
        • Uhde T.W.
        • Stein M.B.
        • Vittone B.J.
        • et al.
        Behavioral and physiological effects of short-term and long-term administration of clonidine in panic disorder.
        Arch Gen Psychiatry. 1989; 46: 170-177
        • Uhde T.W.
        • Vittone B.J.
        • Siever L.J.
        • Kaye W.H.
        • Post R.M.
        Blunted growth hormone response to clonidine in panic disorder patients.
        Biol Psychiatry. 1986; 21: 1077-1081
        • Wood K.
        • Whiting K.
        • Coppen A.
        Lymphocyte beta-adrenergic receptor density of patients with recurrent affective illness.
        J Affect Disord. 1986; 10: 3-8
        • Zak J.P.
        • Miller J.A.
        • Sheehan D.V.
        • Fanous B.S.L.
        The potential role of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder.
        J Clin Psychiatry. 1988; 49 (Suppl): 23-29
        • Zohar J.
        • Insel T.R.
        Obsessive-compulsive disorder: Psychobiological approaches to diagnosis, treatment, and pathophysiology.
        Biol Psychiatry. 1987; 22: 667-687
        • Zohar J.
        • Mueller E.A.
        • Insel T.R.
        • Zohar-Kadouch R.C.
        • Murphy D.L.
        Serotonergic responsivity in obsessive-compulsive disorder: Comparison of patients and healthy controls.
        Arch Gen Psychiatry. 1987; 44: 946-951